TRNK1_HUMAN - dbPTM
TRNK1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TRNK1_HUMAN
UniProt AC O15050
Protein Name TPR and ankyrin repeat-containing protein 1
Gene Name TRANK1
Organism Homo sapiens (Human).
Sequence Length 2925
Subcellular Localization
Protein Description
Protein Sequence MWDPRAARVPPRDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYVKGYYRAGYSLLRLHQPYEAARMFFEGLRLVQRSQDQAPVADFLVGVFTTMSSDSIVLQSFLPCFDHIFTTGFPTEVWQSVIEKLAKKGLWHSFLLLSAKKDRLPRNIHVPELSLKSLFEKYVFIGLYEKMEQVPKLVQWLISIGASVETIGPYPLHALMRLCIQARENHLFRWLMDHKPEWKGRINQKDGDGCTVLHVVAAHSPGYLVKRQTEDVQMLLRFGADPTLLDRQSRSVVDVLKRNKNFKAIEKINSHLEKLATCSKDLSGFSNGDGPTSENDIFRKVLEQLVKYMNSGNRLLHKNFLKQEVVQRFLRLLSTLQEIPPDLVCDINQDCATTVFKFLLEKQRWPEVLLLLTRKVSGEPPLGDCLIKDCNFSDLDICTIIPHLSTWDQRKKQLLGCLIDSGALPDGLQESQERPVVTCLKHEDFELAFLLLTKGADPRAISLTEGDTPLHAALHIFLEIKADIGFSFLSHLLDLFWSNPTEFDYLNPNVQDSNGNTLMHILFQKGMLKRVKKLLDLLVKFDINFNLKNKEGKDARHRIKKNDSLLLAWNKALMENRRRSRQDSAAHLGKLSKSTAPGHTSQLKSQGSFKSVPCGATARTLPEGSAVPDSWETLPGTQVTRKEPGALRPCSLRDCLMQDITVLIQQVEVDPSFPEDCLQSSEPLEAGAGKEGKKDDKPTLGAGAPDCSEVGEGHAQVGLGALQLVPDDNRGKEGNDDQDDWSTQEIEACLQDFDNMTWEIECTSEMLKKLSSKVMTKVIKKKIILAIQQLGNGEWTQGLQKRLKHLKGSIQLFEAKLDKGARMLWELAIDFSPRCSENPEKIIATEQNTCAMEKSGRIYTEIIRIWDIVLDHCKLADSIKAICNAYNRGLSCVLRKKLKGINKGQVSANMKIQKRIPRCYVEDTEAEKGREHVNPEYFPPASAVETEYNIMKFHSFSTNMAFNILNDTTATVEYPFRVGELEYAVIDLNPRPLEPIILIGRSGTGKTTCCLYRLWKKFHVYWEKAEQAGSPLLAKQVWLKRRLEVEPGKESPGGEEEEEEEDEEEEDSIEVETVESIDEQEYEACAGGAGVEPAGDGQAAEVCAPEHPHQLEHLHQIFVTKNHVLCQEVQRNFIELSKSTKATSHYKPLDPNIHKLQDLRDENFPLFVTSKQLLLLLDASLPKPFFLRNEDGSLKRTIIGWSAQEESTIPSWQEDEEEAEVDGDYSEEDKAVEMRTGDSDPRVYVTFEVFKNEIWPKMTKGRTAYNPALIWKEIKSFLKGSFEALSCPHGRLTEEVYKKLGRKRCPNFKEDRSEIYSLFSLYQQIRSQKGYFDEEDVLYNISRRLSKLRVLPWSIHELYGDEIQDFTQAELALLMKCINDPNSMFLTGDTAQSIMKGVAFRFSDLRSLFHYASRNTIDKQCAVRKPKKIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDSGLFDGPKPTVLESCSVSDLAILLRGNKRKTQPIEFGAHQVILVANETAKEKIPEELGLALVLTIYEAKGLEFDDVLLYNFFTDSEAYKEWKIISSFTPTSTDSREENRPLVEVPLDKPGSSQGRSLMVNPEMYKLLNGELKQLYTAITRARVNLWIFDENREKRAPAFKYFIRRDFVQVVKTDENKDFDDSMFVKTSTPAEWIAQGDYYAKHQCWKVAAKCYQKGGAFEKEKLALAHDTALSMKSKKVSPKEKQLEYLELAKTYLECKEPTLSLKCLSYAKEFQLSAQLCERLGKIRDAAYFYKRSQCYKDAFRCFEQIQEFDLALKMYCQEELFEEAAIAVEKYEEMLKTKTLPISKLSYSASQFYLEAAAKYLSANKMKEMMAVLSKLDIEDQLVFLKSRKRLAEAADLLNREGRREEAALLMKQHGCLLEAARLTADKDFQASCLLGAARLNVARDSDIEHTKDILREALDICYQTGQLSGIAEAHFLQGVILRDFQKLRDAFFKFDTLNHSAGVVEALYEAASQCEAEPEKILGLAPGGLEILLSLVRALKRVTNNAEKEMVKSCFEFFGISQVDAKYCQIAQNDPGPILRIIFDLDLNLREKKTKDHFLIMTDQVKLALNKHLLGRLCQITRSLLGKTYRGVCMRFIVGLKCEDENCEHFHRPLRRCEAKCLVQSKMNLVAINGLLLEAKKVFPKILAEELKEIDYILSTDMYGLCKSILDVLFPKHFHQRVLSENPMACKEILKPNYKSFRFYRFALKEYIHFLFENESARNRRESTDLWLSAMQAFLLSSNYPEEFEKLLHQEEDNYNRELKALESEKDERGRGRGSRIKGIEGKFGMLAPNRDDENMDKTHLCFIRLLENCIDQFYVYRNPEDYKRLFFRFMNVLIKRCKEPLIPSIGNTVALLEFQFIHCGVVLARLWKNVILCLPKSYIALLHYWEFLFSKKDKELGDVFSIIQEYKPKDVTRAIQDFRFHLSYLAKVLCGYENVNFNVLLDAFSEIDYVVSGEAERTLVLCLVMLVNAEEILQPYCKPLLYRHFREIESRLQLMSMDCPGQVPERLLKVVKRVLVAVNVKSVAEALQDLLFERDEEYLMDCDWRWDPVHTKGSIVRGLYYEEVRLNRLLCLDPVDYFAEPECEFGQDEMDELALEDRDHVLATILSQKQRKASIQRKLRRACLVVSLCISWRRRVGTQMERVREEAREPRAGNFKKADVDRTQCDLCGVKFTRGPENYFSPSKAFEGAASEVAVLSRAELEREECQERNSESYEQHIHLEHHQRQQVAYQKYSEFFHEKVDPAIDEGKLVVQDIEQSVWIHSHVGSKEHSHMLQKVQEHIKRVSDMVEDLYRRKAWAGAEEAMTRLVNILILSVRDARDWLMKTETRLKKEGIVQEDDYENEVEDFGELRPRRRSRKCGKQRKY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
50UbiquitinationQWDPTYVKGYYRAGY
CCCCCCHHHHHHHCH		30.68-
202PhosphorylationSVETIGPYPLHALMR
CCCCCCCCHHHHHHH		17.14-
283PhosphorylationLLDRQSRSVVDVLKR
HHHHHCHHHHHHHHH		31.5724114839
289UbiquitinationRSVVDVLKRNKNFKA
HHHHHHHHHCCCHHH		54.49-
306UbiquitinationKINSHLEKLATCSKD
HHHHHHHHHHHCCCC		50.19-
312MethylationEKLATCSKDLSGFSN
HHHHHCCCCCCCCCC		65.9123644510
318PhosphorylationSKDLSGFSNGDGPTS
CCCCCCCCCCCCCCC		43.3524719451
324PhosphorylationFSNGDGPTSENDIFR
CCCCCCCCCHHHHHH		54.9524719451
325PhosphorylationSNGDGPTSENDIFRK
CCCCCCCCHHHHHHH		37.2224719451
407UbiquitinationVLLLLTRKVSGEPPL
HHHHHHCCCCCCCCC		35.20-
420UbiquitinationPLGDCLIKDCNFSDL
CCCCCEECCCCCCCC		43.19-
561UbiquitinationLFQKGMLKRVKKLLD
HHHCCHHHHHHHHHH		46.37-
565AcetylationGMLKRVKKLLDLLVK
CHHHHHHHHHHHHHH		51.9630589841
596PhosphorylationHRIKKNDSLLLAWNK
HHHCCCHHHHHHHHH		30.2527067055
616PhosphorylationRRRSRQDSAAHLGKL
HHHHHHHHHHHHHHH		21.0127251275
636UbiquitinationPGHTSQLKSQGSFKS
CCCHHHCCCCCCCCC		32.85-
636MethylationPGHTSQLKSQGSFKS
CCCHHHCCCCCCCCC		32.85115972389
652PhosphorylationPCGATARTLPEGSAV
CCCCEEEECCCCCCC		44.17-
662PhosphorylationEGSAVPDSWETLPGT
CCCCCCCCCCCCCCC		22.27-
669PhosphorylationSWETLPGTQVTRKEP
CCCCCCCCCCCCCCC		20.23-
704PhosphorylationQQVEVDPSFPEDCLQ
EEEECCCCCCHHHHC		49.31-
803PhosphorylationSEMLKKLSSKVMTKV
HHHHHHHCCHHHHHH		36.6723612710
804PhosphorylationEMLKKLSSKVMTKVI
HHHHHHCCHHHHHHH		39.4423612710
864PhosphorylationWELAIDFSPRCSENP
HHHHHCCCCCCCCCH		14.0028258704
877PhosphorylationNPEKIIATEQNTCAM
CHHHEEEECCCCHHH		27.9123403867
886UbiquitinationQNTCAMEKSGRIYTE
CCCHHHHCCCCHHHH		45.16-
887PhosphorylationNTCAMEKSGRIYTEI
CCHHHHCCCCHHHHH		21.7228258704
918PhosphorylationIKAICNAYNRGLSCV
HHHHHHHHHCCHHHH		7.44-
1009MethylationATVEYPFRVGELEYA
CEEEECEECCEEEEE		30.90115383447
1038UbiquitinationIGRSGTGKTTCCLYR
EECCCCCCHHHHHHH		40.26-
1062PhosphorylationEKAEQAGSPLLAKQV
HHHHHCCCCHHHHHH		18.5226471730
1178PhosphorylationSTKATSHYKPLDPNI
CCCCCCCCCCCCCCH		17.6718083107
1179AcetylationTKATSHYKPLDPNIH
CCCCCCCCCCCCCHH		33.4120167786
1187AcetylationPLDPNIHKLQDLRDE
CCCCCHHHHHHHCCC		44.0120167786
1308PhosphorylationLIWKEIKSFLKGSFE
HHHHHHHHHHCCCHH		41.2824719451
1348PhosphorylationKEDRSEIYSLFSLYQ
CCCHHHHHHHHHHHH		8.6830108239
1349PhosphorylationEDRSEIYSLFSLYQQ
CCHHHHHHHHHHHHH		28.7130108239
1352PhosphorylationSEIYSLFSLYQQIRS
HHHHHHHHHHHHHHH		31.3130108239
1354PhosphorylationIYSLFSLYQQIRSQK
HHHHHHHHHHHHHCC		9.3630108239
1435PhosphorylationKGVAFRFSDLRSLFH
HHHCHHHHHHHHHHH		31.3224719451
1439PhosphorylationFRFSDLRSLFHYASR
HHHHHHHHHHHHHHH		42.5622210691
1443PhosphorylationDLRSLFHYASRNTID
HHHHHHHHHHHCCCC		10.0323403867
1617UbiquitinationLVEVPLDKPGSSQGR
CEECCCCCCCCCCCC		59.99-
1634UbiquitinationMVNPEMYKLLNGELK
CCCHHHHHHHCHHHH		45.23-
1641UbiquitinationKLLNGELKQLYTAIT
HHHCHHHHHHHHHHH		33.67-
1739PhosphorylationKLALAHDTALSMKSK
HHHHHHHHHHHHHCC		21.4530108239
1742PhosphorylationLAHDTALSMKSKKVS
HHHHHHHHHHCCCCC		23.0030108239
1745PhosphorylationDTALSMKSKKVSPKE
HHHHHHHCCCCCHHH		29.1230108239
1763PhosphorylationEYLELAKTYLECKEP
HHHHHHHHHHHCCCC		27.9426074081
1764PhosphorylationYLELAKTYLECKEPT
HHHHHHHHHHCCCCC		10.3726074081
1771PhosphorylationYLECKEPTLSLKCLS
HHHCCCCCCCCHHHH		30.0326074081
1773PhosphorylationECKEPTLSLKCLSYA
HCCCCCCCCHHHHHH		28.4126074081
1779PhosphorylationLSLKCLSYAKEFQLS
CCCHHHHHHHHHHHH		14.56-
1845PhosphorylationAAIAVEKYEEMLKTK
HHHHHHHHHHHHCCC		12.01-
1853PhosphorylationEEMLKTKTLPISKLS
HHHHCCCCCCHHHCC		42.89-
1858UbiquitinationTKTLPISKLSYSASQ
CCCCCHHHCCCCHHH		42.02-
1860PhosphorylationTLPISKLSYSASQFY
CCCHHHCCCCHHHHH		22.30-
1861PhosphorylationLPISKLSYSASQFYL
CCHHHCCCCHHHHHH		20.77-
1862PhosphorylationPISKLSYSASQFYLE
CHHHCCCCHHHHHHH		20.33-
1900UbiquitinationEDQLVFLKSRKRLAE
HHHHHHHHHHHHHHH		36.43-
1926UbiquitinationEEAALLMKQHGCLLE
HHHHHHHHHHCHHHH		38.83-
2049PhosphorylationGGLEILLSLVRALKR
CHHHHHHHHHHHHHH		22.7524719451
2144PhosphorylationRSLLGKTYRGVCMRF
HHHCCCCHHHCHHHH		14.62-
2246MethylationSENPMACKEILKPNY
CCCCCCHHHHHCCCC		37.9523644510
2246TrimethylationSENPMACKEILKPNY
CCCCCCHHHHHCCCC		37.95-
2408PhosphorylationLIPSIGNTVALLEFQ
CCCCCCCHHHHHHHH		11.27-
2450PhosphorylationHYWEFLFSKKDKELG
HHHHHHHCCCCHHHH		40.7324719451
2569UbiquitinationQVPERLLKVVKRVLV
CCCHHHHHHHHHHHH		49.96-
2572UbiquitinationERLLKVVKRVLVAVN
HHHHHHHHHHHHHCC		39.51-
2664PhosphorylationDRDHVLATILSQKQR
CHHHHHHHHCCHHHH		20.49-
2691PhosphorylationLVVSLCISWRRRVGT
HHHHHHHHHHHHHCH		17.3424719451
2698PhosphorylationSWRRRVGTQMERVRE
HHHHHHCHHHHHHHH		23.1429496963
2741PhosphorylationRGPENYFSPSKAFEG
CCCCCCCCHHHHHCC		20.2225159151
2855AcetylationVEDLYRRKAWAGAEE
HHHHHHHHHHCCHHH		39.0018604389
2900PhosphorylationGIVQEDDYENEVEDF
CCCCCCCCCCCCCCH		32.7327642862
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TRNK1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TRNK1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TRNK1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TRNK1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TRNK1_HUMAN

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Related Literatures of Post-Translational Modification

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