dbPTM

TRMO_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TRMO_MOUSE
UniProt AC	Q562D6
Protein Name	tRNA (adenine(37)-N6)-methyltransferase
Gene Name	Trmo {ECO:0000312\|MGI:MGI:1922003}
Organism	Mus musculus (Mouse).
Sequence Length	431
Subcellular Localization
Protein Description	S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA..
Protein Sequence	MRGLEKQGSCATAAPCGCVQPALEAGNLLTEPIGYLESCFPAKIGTPRQPSICSHSRACLKIRKNIFNNPEHSLMGLEEFSHVWILFVFHKNGHLNYKAKVQPPRLNGAKTGVFSTRSPHRPNAIGLTLAKLEKVEGGAVYLSGVDMIDGTPVLDIKPYIADYDSPQNLSVHNDHHKLRAEAQVDGTANSCDQLLLSGRGKVQPRQSTKERPKCLEDRTSGENSQKSRDMSEIQHTLPEDRERALDLALEPSRGESMDMPENQLGPPELKSFLEEGTDRPRKVEGALVLPGSSAETQWDASYRARTADRVPYSVVPSWVTEAPVAPLQVRFTPHAEMDLRKLNSGDASQPSFKYFHSAEEAKRAIEAVLSADPRSVYRRKLCEDRLFFFTVDTAHVTCWFGDGFAEVVRIKLASESVQVADPEESLAALGS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
252	Phosphorylation	LDLALEPSRGESMDM HHHHHCCCCCCCCCC	26643407
256	Phosphorylation	LEPSRGESMDMPENQ HCCCCCCCCCCCHHH	26643407
292	Phosphorylation	GALVLPGSSAETQWD EEEECCCCCCCCCCC	26239621
293	Phosphorylation	ALVLPGSSAETQWDA EEECCCCCCCCCCCH	26239621
296	Phosphorylation	LPGSSAETQWDASYR CCCCCCCCCCCHHHH	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TRMO_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TRMO_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TRMO_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TRMO_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TRMO_MOUSE

Related Literatures of Post-Translational Modification