dbPTM

TRIP6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TRIP6_MOUSE
UniProt AC	Q9Z1Y4
Protein Name	Thyroid receptor-interacting protein 6
Gene Name	Trip6
Organism	Mus musculus (Mouse).
Sequence Length	480
Subcellular Localization	Cytoplasm, cytoskeleton . Cell junction, focal adhesion . Nucleus . Cytoplasm . Shuttles between nucleus and cytoplasm. Colocalizes with actin.
Protein Description	Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor (By similarity)..
Protein Sequence	MSGPTWLPPKQPEPSRLPQGRSLPRGALGPPTAHGATLQPHPRVNFCPLPPEHCYQPPGVPEDRGPTWVGSHGTPQRLQGLPPDRGIIRPGSLDAEIDSLTSMLADLDGGRSHAPRRPDRQAFEAPPPHAYRGGSLKPSGGAVPTPMLPASHYGGPTPASYATASTPAGPAFPVQVKVAQPVRGCGLPRRGASQASGPLPGPHFPLTGRGEVWGAGYRSHREPGPGVPEGPSGVHIPAGGGRGGGHEPQGPLGQPPEEELERLTKKLVHDMSHPPSGEYFGRCGGCGEDVVGDGAGVVALDRVFHIGCFVCSTCRAQLRGQHFYAVERRAYCESCYVATLEKCSTCSEPILDRILRAMGKAYHPGCFTCVVCHRGLDGIPFTVDATSQIHCIEDFHRKFAPRCSVCGGAIMPEPGQEETVRIVALDRSFHIGCYKCEECGLLLSSEGECQGCYPLDGHILCKACSAWRIQELSATVTTDC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	SRLPQGRSLPRGALG CCCCCCCCCCCCCCC	49.93	29514104
25	Methylation	PQGRSLPRGALGPPT CCCCCCCCCCCCCCC	48.59	24129315
25	Asymmetric dimethylarginine	PQGRSLPRGALGPPT CCCCCCCCCCCCCCC	48.59	-
55	Phosphorylation	PLPPEHCYQPPGVPE CCCHHHCCCCCCCCC	26.43	22817900
92	Phosphorylation	RGIIRPGSLDAEIDS CCCCCCCCCHHHHHH	26.26	26239621
99	Phosphorylation	SLDAEIDSLTSMLAD CCHHHHHHHHHHHHH	38.93	23984901
101	Phosphorylation	DAEIDSLTSMLADLD HHHHHHHHHHHHHCC	18.95	23984901
102	Phosphorylation	AEIDSLTSMLADLDG HHHHHHHHHHHHCCC	19.66	23984901
111	Methylation	LADLDGGRSHAPRRP HHHCCCCCCCCCCCC	30.69	-
183	Methylation	VKVAQPVRGCGLPRR EEEECCCCCCCCCCC	41.17	12019297
190	Methylation	RGCGLPRRGASQASG CCCCCCCCCCCCCCC	42.99	24129315
193	Phosphorylation	GLPRRGASQASGPLP CCCCCCCCCCCCCCC	29.15	22817900
196	Phosphorylation	RRGASQASGPLPGPH CCCCCCCCCCCCCCC	33.05	18846507
207	Phosphorylation	PGPHFPLTGRGEVWG CCCCCCCCCCCCCCC	25.68	18846507
209	Methylation	PHFPLTGRGEVWGAG CCCCCCCCCCCCCCC	32.63	24129315
218	Methylation	EVWGAGYRSHREPGP CCCCCCCCCCCCCCC	25.68	12019327
242	Methylation	HIPAGGGRGGGHEPQ CCCCCCCCCCCCCCC	43.81	24129315
279	Phosphorylation	SHPPSGEYFGRCGGC CCCCCCCCCCCCCCC	18.17	29514104
344	Phosphorylation	VATLEKCSTCSEPIL EEEHHHHCCCCHHHH	43.44	21454597
345	Phosphorylation	ATLEKCSTCSEPILD EEHHHHCCCCHHHHH	29.53	21454597
347	Phosphorylation	LEKCSTCSEPILDRI HHHHCCCCHHHHHHH	46.63	21454597
419	Phosphorylation	PEPGQEETVRIVALD CCCCCCCCEEEEEEE	17.84	-
428	Phosphorylation	RIVALDRSFHIGCYK EEEEEECCEEEECEE	22.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
55	Y	Phosphorylation	Kinase	SRC	P12931	PSP
55	Y	Phosphorylation	Kinase	SRC	P05480	Uniprot
55	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TRIP6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TRIP6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TRIP6_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TRIP6_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92, AND MASSSPECTROMETRY.	19131326 [Abstract]