TRI46_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRI46_MOUSE
• UniProt AC: Q7TNM2
• Protein Name: Tripartite motif-containing protein 46
• Gene Name: Trim46
• Organism: Mus musculus (Mouse).
• Sequence Length: 759
• Subcellular Localization: Cell projection, axon . Cytoplasm, cytoskeleton . Microtubule-associated. Localizes to the proximal part of the axon.
• Protein Description: Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon formation, the establishment of neuronal polarity and proper neuronal migration..
• Protein Sequence: MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREVLGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGALHPQTILFPCPACQGDVELGERGLSGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLAYILGNQDTVQTQICELEETIRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLSRLSAQIHEHQSLLDGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKLLTELSFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDGRWGASRERLAISKDQRAVRSIPGLPLLLAAERLLTGCHLSVDVVLGDVAVTQGRSYWACAVDPASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDAAVEALPPFAFLTIGMGKILLGSGASSNAGLTGRDGPTASCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	EVLGQQGYIGHGGDP HHHCCCCCCCCCCCC	10.21	20415495
74	Phosphorylation	IGHGGDPSSEPTSPA CCCCCCCCCCCCCCC	52.66	19060867
75	Phosphorylation	GHGGDPSSEPTSPAS CCCCCCCCCCCCCCC	53.64	19060867
78	Phosphorylation	GDPSSEPTSPASTPS CCCCCCCCCCCCCCC	43.20	21183079
79	Phosphorylation	DPSSEPTSPASTPST CCCCCCCCCCCCCCC	29.23	30372032
82	Phosphorylation	SEPTSPASTPSTRSP CCCCCCCCCCCCCCC	44.21	19060867
83	Phosphorylation	EPTSPASTPSTRSPR CCCCCCCCCCCCCCC	24.30	20415495
85	Phosphorylation	TSPASTPSTRSPRLS CCCCCCCCCCCCCCC	36.22	24759943
86	Phosphorylation	SPASTPSTRSPRLSR CCCCCCCCCCCCCCC	36.05	29899451
88	Phosphorylation	ASTPSTRSPRLSRRT CCCCCCCCCCCCCCC	17.92	29899451
108	Phosphorylation	RLDRLLKSGFGTYPG HHHHHHHCCCCCCCC	39.05	23527152
112	Phosphorylation	LLKSGFGTYPGRKRG HHHCCCCCCCCCCCC	25.04	23527152
113	Phosphorylation	LKSGFGTYPGRKRGA HHCCCCCCCCCCCCC	12.22	24759943
330	Phosphorylation	VLEEKRASLLQAIEE HHHHHHHHHHHHHHH	33.38	25521595
550	Ubiquitination	RERLAISKDQRAVRS HHHHEECCCHHHHHC	52.33	22790023
627	Phosphorylation	QGAPDVISPRYDPDS CCCCCCCCCCCCCCC	11.81	23527152
630	Phosphorylation	PDVISPRYDPDSGHD CCCCCCCCCCCCCCC	34.90	29899451
634	Phosphorylation	SPRYDPDSGHDSGAE CCCCCCCCCCCCCCC	43.33	29899451
638	Phosphorylation	DPDSGHDSGAEDAAV CCCCCCCCCCCHHHH	33.94	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRI46_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRI46_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRI46_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TRI46_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.