| UniProt ID | TRAM2_HUMAN | |
|---|---|---|
| UniProt AC | Q15035 | |
| Protein Name | Translocating chain-associated membrane protein 2 | |
| Gene Name | TRAM2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 370 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . |
|
| Protein Description | Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT). [PubMed: 27499293] | |
| Protein Sequence | MAFRRRTKSYPLFSQEFVIHNHADIGFCLVLCVLIGLMFEVTAKTAFLFILPQYNISVPTADSETVHYHYGPKDLVTILFYIFITIILHAVVQEYILDKISKRLHLSKVKHSKFNESGQLVVFHFTSVIWCFYVVVTEGYLTNPRSLWEDYPHVHLPFQVKFFYLCQLAYWLHALPELYFQKVRKEEIPRQLQYICLYLVHIAGAYLLNLSRLGLILLLLQYSTEFLFHTARLFYFADENNEKLFSAWAAVFGVTRLFILTLAVLAIGFGLARMENQAFDPEKGNFNTLFCRLCVLLLVCAAQAWLMWRFIHSQLRHWREYWNEQSAKRRVPATPRLPARLIKRESGYHENGVVKAENGTSPRTKKLKSP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | AFRRRTKSYPLFSQE CCCCCCCCCCCCCCE | 31.22 | 24275569 | |
| 55 | N-linked_Glycosylation | LFILPQYNISVPTAD HHHHCCCCEECCCCC | 18.14 | UniProtKB CARBOHYD | |
| 108 | Ubiquitination | SKRLHLSKVKHSKFN HHHHCHHHCCCCCCC | 62.76 | - | |
| 334 | Phosphorylation | AKRRVPATPRLPARL HHHCCCCCCCCCHHH | 11.67 | 19664994 | |
| 346 | Phosphorylation | ARLIKRESGYHENGV HHHHHCCCCCCCCCC | 49.00 | 25159151 | |
| 348 | Phosphorylation | LIKRESGYHENGVVK HHHCCCCCCCCCCEE | 18.42 | 28796482 | |
| 360 | Phosphorylation | VVKAENGTSPRTKKL CEECCCCCCCCCCCC | 47.33 | 29514088 | |
| 361 | Phosphorylation | VKAENGTSPRTKKLK EECCCCCCCCCCCCC | 17.49 | 29978859 | |
| 364 | Phosphorylation | ENGTSPRTKKLKSP- CCCCCCCCCCCCCC- | 35.60 | 29514088 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TRAM2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TRAM2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TRAM2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of TRAM2_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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