TRAIP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRAIP_MOUSE
• UniProt AC: Q8VIG6
• Protein Name: E3 ubiquitin-protein ligase TRAIP
• Gene Name: Traip
• Organism: Mus musculus (Mouse).
• Sequence Length: 470
• Subcellular Localization: Cytoplasm . Cytoplasm, perinuclear region . Nucleus . Nucleus, nucleolus . In the nucleus, found in close proximity to PCNA, suggesting localization at replication foci. After UV irradiation, rapidly localizes to sites of DNA damage, where it colocal
• Protein Description: E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (By similarity). [PubMed: 17544371]
• Protein Sequence: MPIRALCTICSDFFDHSRDVAAIHCGHTFHLQCLIQWFETAPSRTCPQCRIQVGKKTIINKLFFDLAQEEENVLDAEFLKNELDSVKAQLSQKDREKRDSQAIIDTLRDTLEERNATVESLQNALNKAEMLCSTLKKQMKFLEQRQDETKQAREEAHRLKCKMKTMEQIELLLQSQRSEVEEMIRDMGVGQSAVEQLAVYCVSLKKEYENLKEARKATGELADRLKKDLVSSRSKLKTLNTELDQAKLELRSAQKDLQSADQEITSLRKKLMILQGTLSLPPATNETVSRLVFESPAPVEMMNPRLHQPPFGDEIDLNTTFDVNTPPTQTSGSQHCLPKKLCLERARSPMQNVLKKVHKVSKPESQLSLGGQRCVGELDEELAGAFPLFIRNAVLGQKQPNRTTAESRCSTDVVRIGFDGLGGRTKFIQPRDTTIIRPVPVKSKAKSKQKVRIKTVSSASQPKLDTFLCQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
192	Phosphorylation	RDMGVGQSAVEQLAV HHCCCCHHHHHHHHH	28.49	20047950
192 (in isoform 2)	Phosphorylation	-	28.49	20047950
200	Phosphorylation	AVEQLAVYCVSLKKE HHHHHHHHHHHHHHH	4.98	20047950
200 (in isoform 2)	Phosphorylation	-	4.98	20047950
226	Acetylation	GELADRLKKDLVSSR HHHHHHHHHHHHHCH	45.17	19865111
295	Phosphorylation	VSRLVFESPAPVEMM HHHHHHCCCCCHHHC	18.20	28066266
348	Phosphorylation	LCLERARSPMQNVLK HHHHHCCCHHHHHHH	24.60	25266776
403	Phosphorylation	GQKQPNRTTAESRCS CCCCCCCCCCHHHCC	36.68	28059163
443	Phosphorylation	IRPVPVKSKAKSKQK EEECCCCCCCCCCCC	37.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRAIP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRAIP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRAIP_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TRAIP_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.