TRADD_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRADD_MOUSE
• UniProt AC: Q3U0V2
• Protein Name: Tumor necrosis factor receptor type 1-associated DEATH domain protein
• Gene Name: Tradd {ECO:0000312|MGI:MGI:109200}
• Organism: Mus musculus (Mouse).
• Sequence Length: 310
• Subcellular Localization: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Shuttles between the cytoplasm and the nucleus.
• Protein Description: Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (By similarity). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A..
• Protein Sequence: MAAGQNGHEEWVGSAYLFLESAVDKVILSEAYTDPKKKVAIYKALQTALSESGDSSDVLQILKIHCSDPQLIVQLRFCGRVLCGRFLQAYREGALRTALQRCMAPALAQEALRLQLELRAGAEQLDSWLTDEERCLNYILAQKPDRLRDEELAELEDELCKLTCDCTGQGGAIQVASAGSKFPVSSPTEEKPLPAACQTFLFHGQLVVNRPLTLQDQQTFARSVGLKWRRVGRSLQRNCRALRDPALDSLAYEYERDGLYEQAFQLLRRFMQAEGRRATLQRLVEALEENELTSLAEDLLGQAEPDGGLA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Phosphorylation	KALQTALSESGDSSD HHHHHHHHHCCCCHH	27.53	26643407
52	Phosphorylation	LQTALSESGDSSDVL HHHHHHHCCCCHHHH	44.52	26643407
55	Phosphorylation	ALSESGDSSDVLQIL HHHHCCCCHHHHHHH	31.78	26643407
56	Phosphorylation	LSESGDSSDVLQILK HHHCCCCHHHHHHHH	36.16	26643407
97	Phosphorylation	YREGALRTALQRCMA HHHHHHHHHHHHHHH	32.35	-
143	Ubiquitination	LNYILAQKPDRLRDE HHHHHHCCCCHHCHH	43.19	-
185	Phosphorylation	AGSKFPVSSPTEEKP CCCCCCCCCCCCCCC	30.73	29233185
186	Phosphorylation	GSKFPVSSPTEEKPL CCCCCCCCCCCCCCC	35.75	26824392
188	Phosphorylation	KFPVSSPTEEKPLPA CCCCCCCCCCCCCCC	59.74	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRADD_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRADD_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRADD_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TRADD_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.