TPST1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPST1_HUMAN
• UniProt AC: O60507
• Protein Name: Protein-tyrosine sulfotransferase 1
• Gene Name: TPST1
• Organism: Homo sapiens (Human).
• Sequence Length: 370
• Subcellular Localization: Golgi apparatus membrane ; Single-pass type II membrane protein .
• Protein Description: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate..
• Protein Sequence: MVGKLKQNLLLACLVISSVTVFYLGQHAMECHHRIEERSQPVKLESTRTTVRTGLDLKANKTFAYHKDMPLIFIGGVPRSGTTLMRAMLDAHPDIRCGEETRVIPRILALKQMWSRSSKEKIRLDEAGVTDEVLDSAMQAFLLEIIVKHGEPAPYLCNKDPFALKSLTYLSRLFPNAKFLLMVRDGRASVHSMISRKVTIAGFDLNSYRDCLTKWNRAIETMYNQCMEVGYKKCMLVHYEQLVLHPERWMRTLLKFLQIPWNHSVLHHEEMIGKAGGVSLSKVERSTDQVIKPVNVGALSKWVGKIPPDVLQDMAVIAPMLAKLGYDPYANPPNYGKPDPKIIENTRRVYKGEFQLPDFLKEKPQTEQVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	O-linked_Glycosylation	SQPVKLESTRTTVRT CCCEECEECCCEECC	33.36	55825367
46	Phosphorylation	SQPVKLESTRTTVRT CCCEECEECCCEECC	33.36	27251275
47	O-linked_Glycosylation	QPVKLESTRTTVRTG CCEECEECCCEECCC	23.74	55825371
47	Phosphorylation	QPVKLESTRTTVRTG CCEECEECCCEECCC	23.74	27251275
49	Phosphorylation	VKLESTRTTVRTGLD EECEECCCEECCCCE	29.72	24719451
49	O-linked_Glycosylation	VKLESTRTTVRTGLD EECEECCCEECCCCE	29.72	55825375
50	Phosphorylation	KLESTRTTVRTGLDL ECEECCCEECCCCEE	12.52	24719451
50	O-linked_Glycosylation	KLESTRTTVRTGLDL ECEECCCEECCCCEE	12.52	55825379
53	O-linked_Glycosylation	STRTTVRTGLDLKAN ECCCEECCCCEEECC	37.45	55830509
60	N-linked_Glycosylation	TGLDLKANKTFAYHK CCCEEECCCEEEECC	42.17	16859706
65	Phosphorylation	KANKTFAYHKDMPLI ECCCEEEECCCCCEE	12.76	24719451
189	Phosphorylation	MVRDGRASVHSMISR EEECCCHHHHHHHHC	20.99	27251275
199	O-linked_Glycosylation	SMISRKVTIAGFDLN HHHHCCEEEEEECCH	14.24	55829839
208	Phosphorylation	AGFDLNSYRDCLTKW EEECCHHHHHHHHHH	14.92	27282143
262	N-linked_Glycosylation	KFLQIPWNHSVLHHE HHHCCCCCCCCCCCH	16.52	16859706
274	Acetylation	HHEEMIGKAGGVSLS CCHHHHHCCCCCCHH	32.69	19413330
279	O-linked_Glycosylation	IGKAGGVSLSKVERS HHCCCCCCHHHHCCC	30.14	OGP
279	Phosphorylation	IGKAGGVSLSKVERS HHCCCCCCHHHHCCC	30.14	28857561
281	Phosphorylation	KAGGVSLSKVERSTD CCCCCCHHHHCCCCC	27.44	-
286	O-linked_Glycosylation	SLSKVERSTDQVIKP CHHHHCCCCCCCCCC	23.88	19413330
286	Phosphorylation	SLSKVERSTDQVIKP CHHHHCCCCCCCCCC	23.88	19413330
287	Phosphorylation	LSKVERSTDQVIKPV HHHHCCCCCCCCCCC	36.35	-
287	O-linked_Glycosylation	LSKVERSTDQVIKPV HHHHCCCCCCCCCCC	36.35	55830347

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPST1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPST1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPST1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTB_HUMAN	ACTB	physical	26186194
ACTB_HUMAN	ACTB	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.