TPPP3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPPP3_RAT
• UniProt AC: Q5PPN5
• Protein Name: Tubulin polymerization-promoting protein family member 3
• Gene Name: Tppp3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 176
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Description: Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis (By similarity)..
• Protein Sequence: MAASTDIAGLEESFRKFAIHGDPKASGQEMNGKNWAKLCKDCKVADGKAVTGTDVDIVFSKVKAKSARVINYEEFKKALEELATKRFKGKTKEEAFDAICQLIAGKEPANIGVTKAKTGGAVDRLTDTSKYTGSHKERFDESGKGKGIAGRQDILDDSGYVSAYKNAGTYDAKVKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAASTDIAG ------CCCCCCCCC	15.32	-
24	Acetylation	FAIHGDPKASGQEMN HHHCCCCCCCCCCCC	60.98	22902405
33	Acetylation	SGQEMNGKNWAKLCK CCCCCCCCHHHHHCC	44.29	22902405
76	Acetylation	VINYEEFKKALEELA EECHHHHHHHHHHHH	40.18	22902405
77	Ubiquitination	INYEEFKKALEELAT ECHHHHHHHHHHHHH	64.62	-
130	Acetylation	DRLTDTSKYTGSHKE CCCCCCCCCCCCCHH	49.26	22902405
144	Acetylation	ERFDESGKGKGIAGR HHCCCCCCCCCCCCC	67.72	72532525

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPPP3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPPP3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPPP3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TPPP3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.