TPP2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPP2_RAT
• UniProt AC: Q64560
• Protein Name: Tripeptidyl-peptidase 2
• Gene Name: Tpp2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1249
• Subcellular Localization: Cytoplasm. Nucleus. Translocates to the nucleus in responce to gamma-irradiation..
• Protein Description: Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis (By similarity)..
• Protein Sequence: MATAATEEPFPFHGLLPKKETGASSFLCRYPEYDGRGVLIAVLDTGVDPGAPGMQVTTDGKPKIIDIIDTTGSGDVNTATEVEPKDGEITGLSGRVLKIPANWTNPSGKYHIGIKNGYDFYPKALKERIQKERKEKIWDPIHRVALAEACRKQEEFDIANNGSSQANKLIKEELQSQVELLNSFEKKYSDPGPVYDCLVWHDGETWRACVDSNENGDLGKSTVLRNYKEAQEYGSFGTAEMLNYSVNIYDDGNLLSIVTSGGAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKIGDTRLSTMETGTGLIRAMIEVINHKCDLVNYSYGEATHWPNSGRICEVINEAVWKHNTIYVSSAGNNGPCLSTVGCPGGTTSSVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVPNWTLRGTQLMNGTSMSSPNACGGIALVLSGLKANNVDYTVHSVRRALENTAIKADNIEVFAQGHGIIQVDKAYDYLIQNTSFANRLGFTVTVGNNRGIYLRDPVQVAAPSDHGVGIEPVFPENTENSEKISFQLHLALTSNSSWVQCPSHLELMNQCRHINIRVDPRGLREGLHYTEVCGYDIASPNAGPLFRVPITAVIAAKVNESSHYDLAFTDVHFKPGQIRRHFVEVPEGATWAEVTVCSCSSEVSAKFVLHAVQLVKQRAYRSHEFYKFCSLPEKGTLIEAFPVLGGKAIEFCIARWWASLSDVNIDYTISFHGIVCTAPQLNIHASEGINRFDVQSSLKYEDLAPCITLKSWVQTLRPVNAKTRPLGSRDVLPNNRQLYEMVLTYSFHQPKSGEVTPSCPLLCELLYESEFDSQLWIIFDQNKRQMGSGDAYPHQYSLKLEKGDYTIRLQIRHEQISDLDRLKDLPFIVSHRLSNTLSLDIHENHSLALLGKKKSSSLTLPPKYNQPFFVTSLPDDKIPKGAGPGCYLAGSLTLSKTELGKKADVIPVHYYLIPPPTKTKNGSKDKEKDSEKEKDLKEEFTEALRDLKIQWMTKLDSTDIYNELKETYPAYLPLYVARLHQLDAEKERMKRLNEIVDAANAVISHIDQTALAVYIAMKTDPRPDAATIKNDMDKQKSTLVDALCRKGCALADHLLHAQPHDGAAAGDAEAKEEEGESTLESLSETYWETTKWTDLFDTKVLTFAYKHALVNKMYGRGLKFATKLVEEKPTKENWKNCIQLMKLLGWTHCASFTENWLPIMYPPDYCVF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATAATEEP ------CCCCCCCCC	19.76	-
109	Acetylation	NWTNPSGKYHIGIKN CCCCCCCCEEEEEEC	37.68	22902405
115	Acetylation	GKYHIGIKNGYDFYP CCEEEEEECCCCCCH	38.82	22902405
123	Acetylation	NGYDFYPKALKERIQ CCCCCCHHHHHHHHH	55.78	22902405
136	Acetylation	IQKERKEKIWDPIHR HHHHHHHHCCCHHHH	52.73	22902405
171	Acetylation	SQANKLIKEELQSQV HHHHHHHHHHHHHHH	56.42	22902405
183	Phosphorylation	SQVELLNSFEKKYSD HHHHHHHHHHHHCCC	34.45	30181290
401	Acetylation	AEYSLREKLPANQYT EEECHHHCCCCCCCC	54.02	22902405
401	Ubiquitination	AEYSLREKLPANQYT EEECHHHCCCCCCCC	54.02	-
655	Acetylation	AFTDVHFKPGQIRRH EEEECCCCCCCEEEE	33.10	22902405
655	Ubiquitination	AFTDVHFKPGQIRRH EEEECCCCCCCEEEE	33.10	-
880	Acetylation	YPHQYSLKLEKGDYT CCCEEEEEECCCCEE	48.97	22902405
883	Acetylation	QYSLKLEKGDYTIRL EEEEEECCCCEEEEE	68.47	22902405
904	Acetylation	ISDLDRLKDLPFIVS CCCHHHHCCCCEEEE	59.10	22902405
915	Phosphorylation	FIVSHRLSNTLSLDI EEEEECCCCCCCEEE	27.94	-
958	Ubiquitination	VTSLPDDKIPKGAGP EEECCCCCCCCCCCC	69.18	-
958	Acetylation	VTSLPDDKIPKGAGP EEECCCCCCCCCCCC	69.18	22902405
1110	Acetylation	RPDAATIKNDMDKQK CCCCHHHCCCHHHHH	42.41	22902405
1200	Acetylation	KMYGRGLKFATKLVE HHHHHCCHHHHHHHH	35.46	22902405
1204	Acetylation	RGLKFATKLVEEKPT HCCHHHHHHHHCCCC	47.29	22902405
1209	Acetylation	ATKLVEEKPTKENWK HHHHHHCCCCHHHHH	44.47	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPP2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPP2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPP2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TPP2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.