TPM4_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPM4_RAT
• UniProt AC: P09495
• Protein Name: Tropomyosin alpha-4 chain
• Gene Name: Tpm4
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 248
• Subcellular Localization: Cytoplasm, cytoskeleton . Associates with F-actin stress fibers (PubMed:7568216).
• Protein Description: Binds to actin filaments in muscle and non-muscle cells. [PubMed: 7568216 Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (By similarity Smooth muscle contraction is regulated by interaction with caldesmon (By similarity In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity Binds calcium (By similarity]
• Protein Sequence: MAGLNSLEAVKRKIQALQQQADDAEDRAQGLQRELDGERERREKAEGDAAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKSSDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVSKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNELNCI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGLNSLEA ------CCCHHHHHH	31.05	-
6	Phosphorylation	--MAGLNSLEAVKRK --CCCHHHHHHHHHH	32.40	27097102
11	Acetylation	LNSLEAVKRKIQALQ HHHHHHHHHHHHHHH	55.83	22902405
44	Acetylation	GERERREKAEGDAAA HHHHHHHHHHHHHHH	50.34	22902405
44	Succinylation	GERERREKAEGDAAA HHHHHHHHHHHHHHH	50.34	26843850
72	Phosphorylation	RAQERLATALQKLEE HHHHHHHHHHHHHHH	32.28	22673903
76	Acetylation	RLATALQKLEEAEKA HHHHHHHHHHHHHHH	59.73	59120655
82	Acetylation	QKLEEAEKAADESER HHHHHHHHHHHHHHH	56.79	59120643
92	Acetylation	DESERGMKVIENRAM HHHHHHHHHHHHHHC	42.77	22902405
100	Acetylation	VIENRAMKDEEKMEI HHHHHHCCHHHHHHH	62.09	22902405
104	Acetylation	RAMKDEEKMEIQEMQ HHCCHHHHHHHHHHH	39.52	26302492
113	Acetylation	EIQEMQLKEAKHIAE HHHHHHHHHHHHHHH	38.44	26302492
116	Acetylation	EMQLKEAKHIAEEAD HHHHHHHHHHHHHHH	36.31	22902405
125	Acetylation	IAEEADRKYEEVARK HHHHHHHHHHHHHHH	58.52	26302492
126	Phosphorylation	AEEADRKYEEVARKL HHHHHHHHHHHHHHH	20.44	22673903
132	Acetylation	KYEEVARKLVILEGE HHHHHHHHHHHHHHH	37.05	22902405
150	Phosphorylation	AEERAEVSELKSSDL HHHHHHHHHHHHCHH	28.81	22673903
153	Acetylation	RAEVSELKSSDLEEE HHHHHHHHHCHHHHH	43.81	22902405
154	Phosphorylation	AEVSELKSSDLEEEL HHHHHHHHCHHHHHH	41.53	22673903
155	Phosphorylation	EVSELKSSDLEEELK HHHHHHHCHHHHHHH	44.63	18779572
162	Acetylation	SDLEEELKNVTNNLK CHHHHHHHHHHHHHH	53.29	22902405
169	Acetylation	KNVTNNLKSLEAASE HHHHHHHHHHHHHHH	55.93	22902405
177	Acetylation	SLEAASEKYSEKEDK HHHHHHHHHHHHHHH	52.13	22902405
181	Acetylation	ASEKYSEKEDKYEEE HHHHHHHHHHHHHHH	66.33	22902405
184	Acetylation	KYSEKEDKYEEEIKL HHHHHHHHHHHHHHH	56.50	22902405
195	Acetylation	EIKLLSDKLKEAETR HHHHHHHHHHHHHHH	59.07	22902405
197	Acetylation	KLLSDKLKEAETRAE HHHHHHHHHHHHHHH	61.70	59120667
201	Phosphorylation	DKLKEAETRAEFAER HHHHHHHHHHHHHHH	42.08	22673903
212	Acetylation	FAERTVSKLEKTIDD HHHHHHHHHHHHHHH	57.22	22902405
215	Acetylation	RTVSKLEKTIDDLEE HHHHHHHHHHHHHHH	62.31	59120651
216	Phosphorylation	TVSKLEKTIDDLEEK HHHHHHHHHHHHHHH	21.91	-
223	Acetylation	TIDDLEEKLAQAKEE HHHHHHHHHHHHHHH	39.48	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPM4_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPM4_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPM4_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TPM4_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.