TPM3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPM3_RAT
• UniProt AC: Q63610
• Protein Name: Tropomyosin alpha-3 chain
• Gene Name: Tpm3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 248
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Description: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments..
• Protein Sequence: MAGSTTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNEM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGSTTIEA ------CCCCHHHHH	22.20	-
4	Phosphorylation	----MAGSTTIEAVK ----CCCCHHHHHHH	16.91	23984901
5	Phosphorylation	---MAGSTTIEAVKR ---CCCCHHHHHHHH	30.76	23984901
6	Phosphorylation	--MAGSTTIEAVKRK --CCCCHHHHHHHHH	20.65	23984901
11	Acetylation	STTIEAVKRKIQVLQ CHHHHHHHHHHHHHH	55.83	22902405
13	Acetylation	TIEAVKRKIQVLQQQ HHHHHHHHHHHHHHH	31.60	22902405
51	Phosphorylation	QAEAEVASLNRRIQL HHHHHHHHHHHHHHH	31.21	29779826
72	Phosphorylation	RAQERLATALQKLEE HHHHHHHHHHHHHHH	32.28	22673903
76	Acetylation	RLATALQKLEEAEKA HHHHHHHHHHHHHHH	59.73	59120567
82	Acetylation	QKLEEAEKAADESER HHHHHHHHHHHHHHH	56.79	59120545
92	Acetylation	DESERGMKVIENRAL HHHHHHHHHHHHHCC	42.77	59120583
100	Acetylation	VIENRALKDEEKMEL HHHHHCCCCHHHHHH	63.21	22902405
104	Acetylation	RALKDEEKMELQEIQ HCCCCHHHHHHHHHH	35.31	22902405
113	Acetylation	ELQEIQLKEAKHIAE HHHHHHHHHHHHHHH	38.97	26302492
116	Acetylation	EIQLKEAKHIAEEAD HHHHHHHHHHHHHHH	36.31	72585823
125	Acetylation	IAEEADRKYEEVARK HHHHHHHHHHHHHHH	58.52	59120565
126	Phosphorylation	AEEADRKYEEVARKL HHHHHHHHHHHHHHH	20.44	22673903
169	Acetylation	RLMDQNLKCLSAAEE HHHHHHHHHHHHHHH	40.45	26302492
177	Acetylation	CLSAAEEKYSQKEDK HHHHHHHHHHCCCHH	41.53	26302492
179	Phosphorylation	SAAEEKYSQKEDKYE HHHHHHHHCCCHHHH	45.93	-
181	Acetylation	AEEKYSQKEDKYEEE HHHHHHCCCHHHHHH	63.04	26302492
184	Acetylation	KYSQKEDKYEEEIKI HHHCCCHHHHHHHHH	56.50	26302492
190	Acetylation	DKYEEEIKILTDKLK HHHHHHHHHHHHHHH	34.64	22902405
195	Acetylation	EIKILTDKLKEAETR HHHHHHHHHHHHHHH	57.11	26302492
197	Acetylation	KILTDKLKEAETRAE HHHHHHHHHHHHHHH	61.70	26302492
201	Phosphorylation	DKLKEAETRAEFAER HHHHHHHHHHHHHHH	42.08	22673903
212	Acetylation	FAERSVAKLEKTIDD HHHHHHHHHHHHHHH	55.83	59120577
215	Ubiquitination	RSVAKLEKTIDDLED HHHHHHHHHHHHHHH	62.31	-
216	Phosphorylation	SVAKLEKTIDDLEDK HHHHHHHHHHHHHHH	21.91	-
228 (in isoform 2)	Ubiquitination	-	71.25	-
235 (in isoform 3)	Phosphorylation	-	27.99	23984901
246 (in isoform 2)	Phosphorylation	-	42.84	30181290
247 (in isoform 2)	Phosphorylation	-	54.27	28826663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPM3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPM3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPM3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TPM3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.