TPM2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPM2_RAT
• UniProt AC: P58775
• Protein Name: Tropomyosin beta chain
• Gene Name: Tpm2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 284
• Subcellular Localization: Cytoplasm, cytoskeleton . Associates with F-actin stress fibers (PubMed:7568216).
• Protein Description: Binds to actin filaments in muscle and non-muscle cells. [PubMed: 7568216]
• Protein Sequence: MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKDAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESKCGDLEEELKIVTNNLKSLEAQADKYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDITSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDAIKKKM -------CHHHHHHH	7.68	-
12	Acetylation	KKKMQMLKLDKENAI HHHHHHHHCCHHHHH	49.66	59111967
15	Acetylation	MQMLKLDKENAIDRA HHHHHCCHHHHHHHH	64.40	26302492
29	Acetylation	AEQAEADKKQAEDRC HHHHHHHHHHHHHHH	54.56	22902405
30	Acetylation	EQAEADKKQAEDRCK HHHHHHHHHHHHHHH	56.11	22902405
37	Acetylation	KQAEDRCKQLEEEQQ HHHHHHHHHHHHHHH	59.83	26302492
48	Acetylation	EEQQALQKKLKGTED HHHHHHHHHHCCCHH	62.01	22902405
49	Acetylation	EQQALQKKLKGTEDE HHHHHHHHHCCCHHH	42.33	22902405
51	Acetylation	QALQKKLKGTEDEVE HHHHHHHCCCHHHHH	73.07	22902405
53	Phosphorylation	LQKKLKGTEDEVEKY HHHHHCCCHHHHHHH	38.38	-
59	Acetylation	GTEDEVEKYSESVKD CCHHHHHHHHHHHHH	60.29	22902405
60	Phosphorylation	TEDEVEKYSESVKDA CHHHHHHHHHHHHHH	12.26	22609512
61	Phosphorylation	EDEVEKYSESVKDAQ HHHHHHHHHHHHHHH	34.17	22673903
63	Phosphorylation	EVEKYSESVKDAQEK HHHHHHHHHHHHHHH	28.64	22673903
65	Acetylation	EKYSESVKDAQEKLE HHHHHHHHHHHHHHH	57.54	22902405
70	Acetylation	SVKDAQEKLEQAEKK HHHHHHHHHHHHHHH	45.29	22902405
76	Acetylation	EKLEQAEKKATDAEA HHHHHHHHHHHHHHH	51.20	22902405
77	Acetylation	KLEQAEKKATDAEAD HHHHHHHHHHHHHHH	48.28	26302492
79	Phosphorylation	EQAEKKATDAEADVA HHHHHHHHHHHHHHH	44.62	22673903
87	Phosphorylation	DAEADVASLNRRIQL HHHHHHHHHHHHHHH	26.48	28826663
108	Phosphorylation	RAQERLATALQKLEE HHHHHHHHHHHHHHH	32.28	22673903
112	Acetylation	RLATALQKLEEAEKA HHHHHHHHHHHHHHH	59.73	59111965
118	Acetylation	QKLEEAEKAADESER HHHHHHHHHHHHHHH	56.79	59111929
128	Acetylation	DESERGMKVIENRAM HHHHHHHHHHHHHHC	42.77	59111991
136	Acetylation	VIENRAMKDEEKMEL HHHHHHCCHHHHHHH	62.09	22902405
140	Acetylation	RAMKDEEKMELQEMQ HHCCHHHHHHHHHHH	35.31	22902405
149	Acetylation	ELQEMQLKEAKHIAE HHHHHHHHHHHHHHC	38.44	22902405
152	Acetylation	EMQLKEAKHIAEDSD HHHHHHHHHHHCCCC	36.31	22902405
158	Phosphorylation	AKHIAEDSDRKYEEV HHHHHCCCCHHHHHH	30.71	22673903
161	Acetylation	IAEDSDRKYEEVARK HHCCCCHHHHHHHHH	63.10	26302492
162	Phosphorylation	AEDSDRKYEEVARKL HCCCCHHHHHHHHHH	20.44	22673903
168	Acetylation	KYEEVARKLVILEGE HHHHHHHHHHHHHCH	37.05	59113429
179	Phosphorylation	LEGELERSEERAEVA HHCHHHCHHHHHHHH	34.14	22673903
198	Acetylation	GDLEEELKIVTNNLK CCHHHHHHHHHHHHH	38.11	22902405
201	Phosphorylation	EEELKIVTNNLKSLE HHHHHHHHHHHHHHH	23.12	22673903
205	Acetylation	KIVTNNLKSLEAQAD HHHHHHHHHHHHHHH	55.93	22902405
206	Phosphorylation	IVTNNLKSLEAQADK HHHHHHHHHHHHHHH	34.31	22673903
210 (in isoform 2)	Phosphorylation	-	40.49	22673903
213	Acetylation	SLEAQADKYSTKEDK HHHHHHHHCCCHHHH	44.08	22902405
215 (in isoform 2)	Phosphorylation	-	38.45	22673903
215	Phosphorylation	EAQADKYSTKEDKYE HHHHHHCCCHHHHHH	38.45	22673903
216	Phosphorylation	AQADKYSTKEDKYEE HHHHHCCCHHHHHHH	35.05	22673903
216 (in isoform 2)	Phosphorylation	-	35.05	22673903
217	Acetylation	QADKYSTKEDKYEEE HHHHCCCHHHHHHHH	58.96	22902405
217 (in isoform 2)	Acetylation	-	58.96	-
220	Acetylation	KYSTKEDKYEEEIKL HCCCHHHHHHHHHHH	56.50	22902405
226	Acetylation	DKYEEEIKLLEEKLK HHHHHHHHHHHHHHH	50.75	22902405
231	Acetylation	EIKLLEEKLKEAETR HHHHHHHHHHHHHHH	56.32	26302492
233	Acetylation	KLLEEKLKEAETRAE HHHHHHHHHHHHHHH	66.98	59111977
237	Phosphorylation	EKLKEAETRAEFAER HHHHHHHHHHHHHHH	42.08	22673903
248	Acetylation	FAERSVAKLEKTIDD HHHHHHHHHHHHHHH	55.83	22902405
251	Acetylation	RSVAKLEKTIDDLED HHHHHHHHHHHHHHH	62.31	22902405
251 (in isoform 2)	Acetylation	-	62.31	-
252 (in isoform 2)	Phosphorylation	-	21.91	29779826
252	Phosphorylation	SVAKLEKTIDDLEDE HHHHHHHHHHHHHHH	21.91	22673903
261	Phosphorylation	DDLEDEVYAQKMKYK HHHHHHHHHHHHHHH	10.98	22673903
264	Acetylation	EDEVYAQKMKYKAIS HHHHHHHHHHHHHHH	29.23	22902405
268	Acetylation	YAQKMKYKAISEELD HHHHHHHHHHHHHHH	33.45	22902405
271	Phosphorylation	KMKYKAISEELDNAL HHHHHHHHHHHHHHH	29.85	24945867
282	Phosphorylation	DNALNDITSL----- HHHHHHHHCC-----	27.17	24945867
283	Phosphorylation	NALNDITSL------ HHHHHHHCC------	32.20	29779826

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPM2_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
61	S	Phosphorylation	Phosphorylated on Ser-61 by PIK3CG.	22673903
61	S	Phosphorylation	Phosphorylation on Ser-61 is required for ADRB2 internalization (By similarity).	22673903

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPM2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TPM2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.