dbPTM

TPM1_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TPM1_RAT
UniProt AC	P04692
Protein Name	Tropomyosin alpha-1 chain
Gene Name	Tpm1
Organism	Rattus norvegicus (Rat).
Sequence Length	284
Subcellular Localization	Cytoplasm, cytoskeleton . Associates with F-actin stress fibers (PubMed:7568216).
Protein Description	Binds to actin filaments in muscle and non-muscle cells. [PubMed: 7568216]
Protein Sequence	MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDAIKKKM -------CHHHHHHH	7.68	-
4 (in isoform 7)	Phosphorylation	-	6.15	23984901
4 (in isoform 5)	Phosphorylation	-	6.15	23984901
4 (in isoform 8)	Phosphorylation	-	6.15	23984901
4 (in isoform 4)	Phosphorylation	-	6.15	23984901
5 (in isoform 5)	Phosphorylation	-	48.32	23984901
5 (in isoform 8)	Phosphorylation	-	48.32	23984901
5 (in isoform 4)	Phosphorylation	-	48.32	23984901
5 (in isoform 7)	Phosphorylation	-	48.32	23984901
5	Acetylation	---MDAIKKKMQMLK ---CHHHHHHHHHHH	48.32	22902405
6 (in isoform 5)	Phosphorylation	-	47.57	23984901
6 (in isoform 4)	Phosphorylation	-	47.57	23984901
6 (in isoform 7)	Phosphorylation	-	47.57	23984901
6 (in isoform 8)	Phosphorylation	-	47.57	23984901
7	Acetylation	-MDAIKKKMQMLKLD -CHHHHHHHHHHHCC	29.39	22902405
12	Acetylation	KKKMQMLKLDKENAL HHHHHHHHCCHHHHH	49.66	22902405
16 (in isoform 5)	Phosphorylation	-	47.61	28689409
16 (in isoform 4)	Phosphorylation	-	47.61	28689409
16 (in isoform 7)	Phosphorylation	-	47.61	28689409
16 (in isoform 8)	Phosphorylation	-	47.61	28689409
37	Ubiquitination	KAAEDRSKQLEDELV HHHHHHHHHHHHHHH	60.85	-
45	Phosphorylation	QLEDELVSLQKKLKG HHHHHHHHHHHHHCC	37.39	28826663
51 (in isoform 5)	Phosphorylation	-	73.07	25575281
51 (in isoform 8)	Phosphorylation	-	73.07	25575281
51 (in isoform 7)	Phosphorylation	-	73.07	25575281
51 (in isoform 4)	Phosphorylation	-	73.07	25575281
51	Acetylation	VSLQKKLKGTEDELD HHHHHHHCCCHHHHH	73.07	26302492
53	Phosphorylation	LQKKLKGTEDELDKY HHHHHCCCHHHHHHH	38.38	-
59	Acetylation	GTEDELDKYSEALKD CCHHHHHHHHHHHHH	64.40	26302492
59	Ubiquitination	GTEDELDKYSEALKD CCHHHHHHHHHHHHH	64.40	-
60	Phosphorylation	TEDELDKYSEALKDA CHHHHHHHHHHHHHH	16.06	-
61	Phosphorylation	EDELDKYSEALKDAQ HHHHHHHHHHHHHHH	23.33	22673903
65	Acetylation	DKYSEALKDAQEKLE HHHHHHHHHHHHHHH	59.05	26302492
70	Acetylation	ALKDAQEKLELAEKK HHHHHHHHHHHHHHH	34.87	26302492
76	Acetylation	EKLELAEKKATDAEA HHHHHHHHHCCHHHH	41.94	26302492
77	Acetylation	KLELAEKKATDAEAD HHHHHHHHCCHHHHH	48.28	22902405
79	Phosphorylation	ELAEKKATDAEADVA HHHHHHCCHHHHHHH	44.62	22673903
87	O-linked_Glycosylation	DAEADVASLNRRIQL HHHHHHHHHHHHHHH	26.48	26109417
87	Phosphorylation	DAEADVASLNRRIQL HHHHHHHHHHHHHHH	26.48	28826663
108	Phosphorylation	RAQERLATALQKLEE HHHHHHHHHHHHHHH	32.28	22673903
112	Acetylation	RLATALQKLEEAEKA HHHHHHHHHHHHHHH	59.73	22902405
112	Ubiquitination	RLATALQKLEEAEKA HHHHHHHHHHHHHHH	59.73	-
118	Acetylation	QKLEEAEKAADESER HHHHHHHHHHHHHHH	56.79	22902405
123	O-linked_Glycosylation	AEKAADESERGMKVI HHHHHHHHHHHHHHH	32.89	26109417
132	O-linked_Glycosylation	RGMKVIESRAQKDEE HHHHHHHHHHHCCHH	23.07	26109417
136	Acetylation	VIESRAQKDEEKMEI HHHHHHHCCHHHHHH	67.15	26302492
140	Acetylation	RAQKDEEKMEIQEIQ HHHCCHHHHHHHHHH	39.52	26302492
149	Acetylation	EIQEIQLKEAKHIAE HHHHHHHHHHHHHHH	38.97	26302492
161	Acetylation	IAEDADRKYEEVARK HHHHHHHHHHHHHHH	58.52	22902405
162	Phosphorylation	AEDADRKYEEVARKL HHHHHHHHHHHHHHH	20.44	22673903
174	Phosphorylation	RKLVIIESDLERAEE HHHHHHHHHHHHHHH	36.77	27097102
186	O-linked_Glycosylation	AEERAELSEGKCAEL HHHHHHHCCCHHHHH	35.49	26109417
186	Phosphorylation	AEERAELSEGKCAEL HHHHHHHCCCHHHHH	35.49	-
199	Phosphorylation	ELEEELKTVTNNLKS HHHHHHHHHHHHHHH	45.23	22673903
201	Phosphorylation	EEELKTVTNNLKSLE HHHHHHHHHHHHHHH	24.50	22673903
205	Ubiquitination	KTVTNNLKSLEAQAE HHHHHHHHHHHHHHH	55.93	-
206	O-linked_Glycosylation	TVTNNLKSLEAQAEK HHHHHHHHHHHHHHH	34.31	26109417
206	Phosphorylation	TVTNNLKSLEAQAEK HHHHHHHHHHHHHHH	34.31	22673903
213	Acetylation	SLEAQAEKYSQKEDK HHHHHHHHHHCCHHH	53.90	22902405
214	Nitration	LEAQAEKYSQKEDKY HHHHHHHHHCCHHHH	14.08	-
215	Phosphorylation	EAQAEKYSQKEDKYE HHHHHHHHCCHHHHH	45.93	22673903
216 (in isoform 8)	Phosphorylation	-	50.49	25575281
216 (in isoform 7)	Phosphorylation	-	50.49	25575281
217	Acetylation	QAEKYSQKEDKYEEE HHHHHHCCHHHHHHH	63.04	22902405
220	Acetylation	KYSQKEDKYEEEIKV HHHCCHHHHHHHHHH	56.50	22902405
226	Acetylation	DKYEEEIKVLSDKLK HHHHHHHHHHHHHHH	40.16	26302492
233	Acetylation	KVLSDKLKEAETRAE HHHHHHHHHHHHHHH	61.70	22902405
237	Phosphorylation	DKLKEAETRAEFAER HHHHHHHHHHHHHHH	42.08	22673903
248	Acetylation	FAERSVTKLEKSIDD HHHHHHHHHHHCHHH	53.12	26302492
251	Acetylation	RSVTKLEKSIDDLED HHHHHHHHCHHHHHH	64.25	26302492
252 (in isoform 6)	Phosphorylation	-	23.13	25575281
252 (in isoform 2)	Phosphorylation	-	23.13	25575281
252	Phosphorylation	SVTKLEKSIDDLEDE HHHHHHHCHHHHHHH	23.13	28826663
261	Phosphorylation	DDLEDELYAQKLKYK HHHHHHHHHHHHHHH	12.63	22673903
264	Acetylation	EDELYAQKLKYKAIS HHHHHHHHHHHHHHH	38.48	26302492
266	Acetylation	ELYAQKLKYKAISEE HHHHHHHHHHHHHHH	52.30	26302492
267	Phosphorylation	LYAQKLKYKAISEEL HHHHHHHHHHHHHHH	18.98	22609512
271	Phosphorylation	KLKYKAISEELDHAL HHHHHHHHHHHHHHH	29.85	28826663
282	Phosphorylation	DHALNDMTSI----- HHHHHHHCCC-----	26.57	30181290
283	Phosphorylation	HALNDMTSI------ HHHHHHCCC------	21.47	29779826

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
283	S	Phosphorylation	Kinase	DAPK1	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
283	S	Oxidation	-
Phosphorylated at Ser-283 by DAPK1 in response to oxidative stress and this phosphorylation enhances stress fiber formation in endothelial cells.
283	S	Phosphorylation	-
Phosphorylated at Ser-283 by DAPK1 in response to oxidative stress and this phosphorylation enhances stress fiber formation in endothelial cells.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TPM1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TPM1_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TPM1_RAT

Related Literatures of Post-Translational Modification

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