TPM1_PIG - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPM1_PIG
• UniProt AC: P42639
• Protein Name: Tropomyosin alpha-1 chain
• Gene Name: TPM1
• Organism: Sus scrofa (Pig).
• Sequence Length: 284
• Subcellular Localization: Cytoplasm, cytoskeleton . Associates with F-actin stress fibers.
• Protein Description: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments..
• Protein Sequence: MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDAIKKKM -------CHHHHHHH	7.68	-
45	Phosphorylation	RLEDELVSLQKKLKA HHHHHHHHHHHHHHC	37.39	-
53	Phosphorylation	LQKKLKATEDELDKY HHHHHHCCHHHHHHH	42.24	29916714
61	Phosphorylation	EDELDKYSEAPKDAQ HHHHHHHCCCCHHHH	32.78	-
79	Phosphorylation	ELAEKKATDAEADVA HHHHHHCCHHHHHHH	44.62	29916714
87	Phosphorylation	DAEADVASLNRRIQL HHHHHHHHHHHHHHH	26.48	29916714
108	Phosphorylation	RAQERLATALQKLEE HHHHHHHHHHHHHHH	32.28	29916714
123	Phosphorylation	AEKAADESERGMKVI HHHHHHHHHHHHHHH	32.89	29916714
132	Phosphorylation	RGMKVIESRAQKDEE HHHHHHHHHHHCCHH	23.07	29916714
162	Phosphorylation	AEDADRKYEEVARKL HHHHHHHHHHHHHHH	20.44	29916714
174	Phosphorylation	RKLVIIESDLERAEE HHHHHHHHHHHHHHH	36.77	29916714
186	Phosphorylation	AEERAELSEGKCAEL HHHHHHHCCCHHHHH	35.49	29916714
199	Phosphorylation	ELEEELKTVTNNLKS HHHHHHHHHHHHHHH	45.23	29916714
201	Phosphorylation	EEELKTVTNNLKSLE HHHHHHHHHHHHHHH	24.50	29916714
206	Phosphorylation	TVTNNLKSLEAQAEK HHHHHHHHHHHHHHH	34.31	29916714
215	Phosphorylation	EAQAEKYSQKEDKYE HHHHHHHHCCHHHHH	45.93	29916714
221	Phosphorylation	YSQKEDKYEEEIKVL HHCCHHHHHHHHHHH	40.68	29916714
229	Phosphorylation	EEEIKVLSDKLKEAE HHHHHHHHHHHHHHH	35.37	29916714
237	Phosphorylation	DKLKEAETRAEFAER HHHHHHHHHHHHHHH	42.08	29916714
245	Phosphorylation	RAEFAERSVTKLEKS HHHHHHHHHHHHHHC	26.16	29916714
247	Phosphorylation	EFAERSVTKLEKSID HHHHHHHHHHHHCHH	31.03	29916714
252	Phosphorylation	SVTKLEKSIDDLEDE HHHHHHHCHHHHHHH	23.13	29916714
261	Phosphorylation	DDLEDELYAQKLKYK HHHHHHHHHHHHHHH	12.63	29916714
271	Phosphorylation	KLKYKAISEELDHAL HHHHHHHHHHHHHHH	29.85	29916714
282	Phosphorylation	DHALNDMTSI----- HHHHHHHCCC-----	26.57	29916714
283	Phosphorylation	HALNDMTSI------ HHHHHHCCC------	21.47	29916714

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
283	S	Phosphorylation	Kinase	DAPK1	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPM1_PIG !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPM1_PIG !!

Protein-Protein Interaction

Oops, there are no PPI records of TPM1_PIG !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.