TPIS_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPIS_RAT
• UniProt AC: P48500
• Protein Name: Triosephosphate isomerase
• Gene Name: Tpi1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 249
• Protein Sequence: MAPSRKFFVGGNWKMNGRKKCLGELICTLNAAKLPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDLGATWVVLGHSERRHIFGESDELIGQKVNHALSEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVKDWCKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKCNVSEGVAQCTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MAPSRKFFVGGNW --CCCCCCEEECCCC	47.71	14451233
14	Acetylation	FFVGGNWKMNGRKKC EEECCCCCCCCCCCH	26.87	22902405
19	Acetylation	NWKMNGRKKCLGELI CCCCCCCCCHHHHHH	49.60	22902405
21	S-nitrosylation	KMNGRKKCLGELICT CCCCCCCHHHHHHHH	7.09	16418269
21	S-nitrosocysteine	KMNGRKKCLGELICT CCCCCCCHHHHHHHH	7.09	-
27	S-nitrosocysteine	KCLGELICTLNAAKL CHHHHHHHHHCCCCC	5.75	-
27	S-nitrosylation	KCLGELICTLNAAKL CHHHHHHHHHCCCCC	5.75	16418269
33	Ubiquitination	ICTLNAAKLPADTEV HHHHCCCCCCCCCEE	53.22	-
55	Acetylation	YIDFARQKLDPKIAV HHHHHHHHCCHHHHH	49.67	22902405
59	Acetylation	ARQKLDPKIAVAAQN HHHHCCHHHHHEECC	42.86	22902405
67	S-nitrosylation	IAVAAQNCYKVTNGA HHHEECCEEEECCCC	2.01	19101475
67	S-nitrosocysteine	IAVAAQNCYKVTNGA HHHEECCEEEECCCC	2.01	-
68	Nitrated tyrosine	AVAAQNCYKVTNGAF HHEECCEEEECCCCC	18.95	-
68	Nitration	AVAAQNCYKVTNGAF HHEECCEEEECCCCC	18.95	-
69	Acetylation	VAAQNCYKVTNGAFT HEECCEEEECCCCCC	44.79	22902405
71	Phosphorylation	AQNCYKVTNGAFTGE ECCEEEECCCCCCCC	24.63	22673903
76	Phosphorylation	KVTNGAFTGEISPGM EECCCCCCCCCCCCH	33.11	23984901
80	Phosphorylation	GAFTGEISPGMIKDL CCCCCCCCCCHHCCC	15.88	23984901
85	Acetylation	EISPGMIKDLGATWV CCCCCHHCCCCCEEE	37.70	22902405
90	Phosphorylation	MIKDLGATWVVLGHS HHCCCCCEEEEEECC	19.59	22673903
106	Phosphorylation	RRHIFGESDELIGQK CCCCCCCCHHHHHHH	36.44	22673903
119	Phosphorylation	QKVNHALSEGLGVIA HHHHHHHHCCCCEEE	30.33	22673903
131	Acetylation	VIACIGEKLDEREAG EEEEEECCCCHHCCC	56.90	22902405
142	Ubiquitination	REAGITEKVVFEQTK HCCCCCHHHHHHHHH	34.74	-
142	Acetylation	REAGITEKVVFEQTK HCCCCCHHHHHHHHH	34.74	22902405
149	Acetylation	KVVFEQTKAIADNVK HHHHHHHHHHHHHHH	37.17	22902405
149	Succinylation	KVVFEQTKAIADNVK HHHHHHHHHHHHHHH	37.17	-
149	Ubiquitination	KVVFEQTKAIADNVK HHHHHHHHHHHHHHH	37.17	-
149	Succinylation	KVVFEQTKAIADNVK HHHHHHHHHHHHHHH	37.17	-
156	Succinylation	KAIADNVKDWCKVVL HHHHHHHHHHHHHHE	52.33	-
156	Succinylation	KAIADNVKDWCKVVL HHHHHHHHHHHHHHE	52.33	-
156	Acetylation	KAIADNVKDWCKVVL HHHHHHHHHHHHHHE	52.33	22902405
156	Ubiquitination	KAIADNVKDWCKVVL HHHHHHHHHHHHHHE	52.33	-
159	S-nitrosylation	ADNVKDWCKVVLAYE HHHHHHHHHHHEEEC	3.25	19101475
159	S-nitrosocysteine	ADNVKDWCKVVLAYE HHHHHHHHHHHEEEC	3.25	-
160	Acetylation	DNVKDWCKVVLAYEP HHHHHHHHHHEEECC	30.99	25786129
173	Phosphorylation	EPVWAIGTGKTATPQ CCEEEECCCCCCCHH	29.41	23984901
175	Ubiquitination	VWAIGTGKTATPQQA EEEECCCCCCCHHHH	34.52	-
175	Acetylation	VWAIGTGKTATPQQA EEEECCCCCCCHHHH	34.52	22902405
176	Phosphorylation	WAIGTGKTATPQQAQ EEECCCCCCCHHHHH	36.79	30181290
178	Phosphorylation	IGTGKTATPQQAQEV ECCCCCCCHHHHHHH	27.19	30181290
188	Acetylation	QAQEVHEKLRGWLKC HHHHHHHHHHHHHHC	28.71	22902405
194	Succinylation	EKLRGWLKCNVSEGV HHHHHHHHCCCCHHH	19.77	-
194	Acetylation	EKLRGWLKCNVSEGV HHHHHHHHCCCCHHH	19.77	25786129
194	Methylation	EKLRGWLKCNVSEGV HHHHHHHHCCCCHHH	19.77	-
194	Succinylation	EKLRGWLKCNVSEGV HHHHHHHHCCCCHHH	19.77	-
198	Phosphorylation	GWLKCNVSEGVAQCT HHHHCCCCHHHHHCC	18.03	22673903
209	Nitration	AQCTRIIYGGSVTGA HHCCEEEECCCCCCH	17.05	-
209	Phosphorylation	AQCTRIIYGGSVTGA HHCCEEEECCCCCCH	17.05	28689409
209	Nitrated tyrosine	AQCTRIIYGGSVTGA HHCCEEEECCCCCCH	17.05	-
212	Phosphorylation	TRIIYGGSVTGATCK CEEEECCCCCCHHHH	16.49	21738781
214	Phosphorylation	IIYGGSVTGATCKEL EEECCCCCCHHHHHH	23.85	27097102
217	Phosphorylation	GGSVTGATCKELASQ CCCCCCHHHHHHHCC	26.00	27097102
223	Phosphorylation	ATCKELASQPDVDGF HHHHHHHCCCCCCCE	55.67	22673903
238	Acetylation	LVGGASLKPEFVDII EECCCCCCHHHHHHH	39.75	22902405
238	Ubiquitination	LVGGASLKPEFVDII EECCCCCCHHHHHHH	39.75	-
248	Acetylation	FVDIINAKQ------ HHHHHCCCC------	52.64	22902405
248	Ubiquitination	FVDIINAKQ------ HHHHHCCCC------	52.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPIS_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPIS_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPIS_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TPIS_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.