TPH2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPH2_HUMAN
• UniProt AC: Q8IWU9
• Protein Name: Tryptophan 5-hydroxylase 2
• Gene Name: TPH2
• Organism: Homo sapiens (Human).
• Sequence Length: 490
• Protein Sequence: MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATESGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	QPAMMMFSSKYWARR CCCCHHCCHHHHHHC	14.18	29978859
10	Phosphorylation	PAMMMFSSKYWARRG CCCHHCCHHHHHHCC	20.64	29978859
12	Phosphorylation	MMMFSSKYWARRGFS CHHCCHHHHHHCCCC	13.27	29978859
19	Phosphorylation	YWARRGFSLDSAVPE HHHHCCCCCCCCCCH	33.81	18339632
79	Acetylation	NEVGGLVKALRLFQE CCHHHHHHHHHHHHH	46.90	20167786
104	Phosphorylation	RKSRRRSSEVEIFVD HHHCCCCCCEEEEEE	43.80	17973628
202	Ubiquitination	VDVAMGYKYGQPIPR HHHHHCCCCCCCCCC	36.86	25015289
212	Phosphorylation	QPIPRVEYTEEETKT CCCCCEEECHHHHHH	19.32	29759185
213	Phosphorylation	PIPRVEYTEEETKTW CCCCEEECHHHHHHH	24.34	29759185
217	Phosphorylation	VEYTEEETKTWGVVF EEECHHHHHHHHHHH	36.73	29759185
249	Phosphorylation	NFPLLTKYCGYREDN CCCHHHHHCCCCCCC	5.95	28111955
252	Phosphorylation	LLTKYCGYREDNVPQ HHHHHCCCCCCCCCC	13.78	28111955
264	Phosphorylation	VPQLEDVSMFLKERS CCCHHHHHHHHHHCC	19.01	29255136
271	Phosphorylation	SMFLKERSGFTVRPV HHHHHHCCCCEEEEC	39.07	29255136
274	Phosphorylation	LKERSGFTVRPVAGY HHHCCCCEEEECCCC	21.09	29255136
382	Phosphorylation	AYGAGLLSSIGELKH HHCHHHHHHHHHHHH	25.59	17287340
392	Phosphorylation	GELKHALSDKACVKA HHHHHHHCCCHHHHH	37.54	17287340
422	Phosphorylation	FQEAYFVSESFEEAK HHHHHHCCCCHHHHH	20.02	22210691
424	Phosphorylation	EAYFVSESFEEAKEK HHHHCCCCHHHHHHH	30.37	22210691
440	Phosphorylation	RDFAKSITRPFSVYF HHHHHHCCCCCEEEE	39.10	28509920

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
19	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
19	S	Phosphorylation	Kinase	PKACA	P17612	PSP
19	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
19	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
19	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
104	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
104	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPH2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPH2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DJC12_HUMAN	DNAJC12	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 608516: Major depressive disorder (MDD)
• 613003: Attention deficit-hyperactivity disorder 7 (ADHD7)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00150: L-Tryptophan

Related Literatures of Post-Translational Modification

Phosphorylation

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-382 AND SER-392, ANDMASS SPECTROMETRY.
PubMed: 17287340