dbPTM

TPD54_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TPD54_MOUSE
UniProt AC	Q9CYZ2
Protein Name	Tumor protein D54
Gene Name	Tpd52l2
Organism	Mus musculus (Mouse).
Sequence Length	220
Subcellular Localization
Protein Description
Protein Sequence	MDSASQDINLNSPNKGVLSDFMTDVPVDPGVVHRTPVVEGLTEGEEEELRAELAKVEEEIVTLRQVLAAKERHCGELKRRLGLSTLGELKQNLSRSWHDVQVSTAYVKTSEKLGEWNEKVTQSDLYKKTQETLSQAGQKTSAALSTMGSAISRKLGDMSSYSIRHSISMPVMRNSATFKSFEDRVGTIKSKVVGGRENGSDNLPPSPGSGDQTLPDHAPF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDSASQDI -------CCCCCCCC	9.19	-
3	Phosphorylation	-----MDSASQDINL -----CCCCCCCCCC	28.64	25619855
5	Phosphorylation	---MDSASQDINLNS ---CCCCCCCCCCCC	32.13	26824392
12	Phosphorylation	SQDINLNSPNKGVLS CCCCCCCCCCCCCCH	32.77	26824392
19	Phosphorylation	SPNKGVLSDFMTDVP CCCCCCCHHHHCCCC	26.79	25619855
23	Phosphorylation	GVLSDFMTDVPVDPG CCCHHHHCCCCCCCC	33.56	25619855
35	Phosphorylation	DPGVVHRTPVVEGLT CCCCCCCCCCCCCCC	12.93	28066266
55	Ubiquitination	ELRAELAKVEEEIVT HHHHHHHHHHHHHHH	63.90	-
85	Phosphorylation	KRRLGLSTLGELKQN HHHHCCCHHHHHHHH	43.77	27180971
90	Ubiquitination	LSTLGELKQNLSRSW CCHHHHHHHHHCCCC	32.60	-
94	Phosphorylation	GELKQNLSRSWHDVQ HHHHHHHCCCCCCEE	31.64	26745281
96	Phosphorylation	LKQNLSRSWHDVQVS HHHHHCCCCCCEEEE	25.95	23684622
103	Phosphorylation	SWHDVQVSTAYVKTS CCCCEEEEEEEEEHH	7.10	26745281
104	Phosphorylation	WHDVQVSTAYVKTSE CCCEEEEEEEEEHHH	24.13	25367039
106	Phosphorylation	DVQVSTAYVKTSEKL CEEEEEEEEEHHHHH	11.54	25777480
108	Ubiquitination	QVSTAYVKTSEKLGE EEEEEEEEHHHHHHH	33.39	-
112	Ubiquitination	AYVKTSEKLGEWNEK EEEEHHHHHHHHCHH	62.65	-
121	O-linked_Glycosylation	GEWNEKVTQSDLYKK HHHCHHCCHHHHHHH	33.16	55414323
126	Phosphorylation	KVTQSDLYKKTQETL HCCHHHHHHHHHHHH	18.54	29514104
134	Phosphorylation	KKTQETLSQAGQKTS HHHHHHHHHHHHHHH	25.96	18779572
145	Phosphorylation	QKTSAALSTMGSAIS HHHHHHHHHHHHHHH	16.18	29514104
146	Phosphorylation	KTSAALSTMGSAISR HHHHHHHHHHHHHHH	26.80	22807455
149	Phosphorylation	AALSTMGSAISRKLG HHHHHHHHHHHHHHC	16.17	29176673
152	Phosphorylation	STMGSAISRKLGDMS HHHHHHHHHHHCCCC	24.07	23140645
159	Phosphorylation	SRKLGDMSSYSIRHS HHHHCCCCHHCHHHC	30.75	29176673
160	Phosphorylation	RKLGDMSSYSIRHSI HHHCCCCHHCHHHCC	19.09	29176673
162	Phosphorylation	LGDMSSYSIRHSISM HCCCCHHCHHHCCCC	18.33	29176673
166	Phosphorylation	SSYSIRHSISMPVMR CHHCHHHCCCCCEEC	13.40	22324799
168	Phosphorylation	YSIRHSISMPVMRNS HCHHHCCCCCEECCC	21.76	25521595
175	Phosphorylation	SMPVMRNSATFKSFE CCCEECCCCCCCCHH	20.51	25619855
177	Phosphorylation	PVMRNSATFKSFEDR CEECCCCCCCCHHHH	31.27	27742792
180	Phosphorylation	RNSATFKSFEDRVGT CCCCCCCCHHHHHCC	29.67	26824392
187	Phosphorylation	SFEDRVGTIKSKVVG CHHHHHCCCEEEECC	23.52	26824392
200	Phosphorylation	VGGRENGSDNLPPSP CCCCCCCCCCCCCCC	34.60	26824392
206	Phosphorylation	GSDNLPPSPGSGDQT CCCCCCCCCCCCCCC	39.70	25521595
209	Phosphorylation	NLPPSPGSGDQTLPD CCCCCCCCCCCCCCC	42.45	27087446
213	Phosphorylation	SPGSGDQTLPDHAPF CCCCCCCCCCCCCCC	45.02	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TPD54_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TPD54_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TPD54_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TPD54_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TPD54_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180 AND SER-206, ANDMASS SPECTROMETRY.	19131326 [Abstract]
"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis."; Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.; J. Proteome Res. 7:3957-3967(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180, AND MASSSPECTROMETRY.	18630941 [Abstract]
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206, AND MASSSPECTROMETRY.	15345747 [Abstract]