TOR4A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TOR4A_HUMAN
• UniProt AC: Q9NXH8
• Protein Name: Torsin-4A
• Gene Name: TOR4A
• Organism: Homo sapiens (Human).
• Sequence Length: 423
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Sequence: MDRGQPSLEPAAAAPRASGRCVIAPVRAVLRLRRRVCVLRKRRLLQPGGGPDVGTGAPRPGCSPRAPRADLDQPKFFTFDSPAELPSRTPRKKRRRSRLVLYPETSRKYRPRVEHRSRAQRCLLLLVAIVGFQVLNAIENLDDNAQRYDLDGLEKALQRAVFGQPAAVSRIVALMRDYLATHVHSRPLLLALHGPSGVGKSHVGRLLARHFRSVLEDSALVLQYHARHHCPEARAAQDCREELARRVADVVARAEAEEKTPLLVLDDVELMPRPLLDELHGFLQPQRSHHFHNAIYVLLSGAGGAEVTRFVLQNASRALPLRPDGFRSAEAAAAQAEEDLRASLLAVLSREHPLWQAAAIVPFLLLDKRDVVSCFRDEMAGEGFFPDQARAENLAAQLSFYRVAGREFAVTGCKQVVATVNLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Phosphorylation	GGGPDVGTGAPRPGC CCCCCCCCCCCCCCC	29.98	22167270
63	Phosphorylation	GAPRPGCSPRAPRAD CCCCCCCCCCCCCCC	24.28	23401153
75	Ubiquitination	RADLDQPKFFTFDSP CCCCCCCCEECCCCC	47.69	21906983
78	Phosphorylation	LDQPKFFTFDSPAEL CCCCCEECCCCCCCC	29.66	23403867
81	Phosphorylation	PKFFTFDSPAELPSR CCEECCCCCCCCCCC	23.09	25159151
87	Phosphorylation	DSPAELPSRTPRKKR CCCCCCCCCCCCCCC	62.50	25159151
89	Phosphorylation	PAELPSRTPRKKRRR CCCCCCCCCCCCCCH	31.61	25159151
97	Phosphorylation	PRKKRRRSRLVLYPE CCCCCCHHCEEECCC	28.31	28355574
102	Phosphorylation	RRSRLVLYPETSRKY CHHCEEECCCCCCCC	7.49	26699800
105	Phosphorylation	RLVLYPETSRKYRPR CEEECCCCCCCCCCC	29.36	23401153
106	Phosphorylation	LVLYPETSRKYRPRV EEECCCCCCCCCCCH	25.72	30108239
148	Phosphorylation	LDDNAQRYDLDGLEK CCCCHHHCCHHHHHH	14.58	-
155	Ubiquitination	YDLDGLEKALQRAVF CCHHHHHHHHHHHHH	60.48	22817900
259	Ubiquitination	ARAEAEEKTPLLVLD HHHHHHCCCCEEEEC	47.12	23503661
300	Phosphorylation	NAIYVLLSGAGGAEV HHEEEEHHCCCHHHH	23.57	-
368	Ubiquitination	VPFLLLDKRDVVSCF HHHHHCCCCHHHHHC	50.93	21987572
373	Phosphorylation	LDKRDVVSCFRDEMA CCCCHHHHHCCHHHC	13.85	23532336

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TOR4A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TOR4A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TOR4A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TOR4A_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81 AND THR-89, AND MASSSPECTROMETRY.
PubMed: 18669648

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63, AND MASSSPECTROMETRY.
PubMed: 17081983