TOPZ1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TOPZ1_HUMAN
• UniProt AC: Q8N9V7
• Protein Name: Protein TOPAZ1 {ECO:0000250|UniProtKB:E5FYH1}
• Gene Name: TOPAZ1
• Organism: Homo sapiens (Human).
• Sequence Length: 1692
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear..
• Protein Sequence: MRRPPPLGPTTASGPEGNVRNLQKRQAPGPGAAGGCGPEAGGCRENKQKRRMVARATPGRGEVESDKSVAASGAGKAARRQVEGRRGPVSPSDSSDPRGLEAAKEAELPLQTERHTKEKRKVTEASSDDPQPGLDLVRKESLTSSESFQTVECLQSLGKESIIEGIKRRIRNKKLKSLENPPLKITENEATQNIKVEFQDELYKNTPKYSCNILSPEVENNSVLKLRDCNCFPHSKGCNDENNLPYKPDGGCMHVAENFSKKENLRSLAEKSDTNSIPQLLQTEENVMGVNKLLPEESDLYQSKTNGLLSCLQHEKNKYSIEESSVGRKPRKRMKLSEKADETVTEMNFSNEYNKSELMLQENQMIADGKEAETKSPLNVLRKVSHNTVSLMDHLLSVPETVEKETSSEHHVNAVFQKTIEPLLKEETENASEPLGYESMASKEDFKSMKSFIGKSPNEYHIERRSSREDLRSASEELKLSCQRTIPMTGKRTWPYYSCARISAWCWKKASLPESSYFLRGSQESCRQVDVPKHQTNQTHLTDSKLLLQSSLTETNTESSSKEKLDSNSNCLSSVSAVEPTLMVIKEPIIKDDKKIKSEELSRRGSEVISNTTEDTQLTSETQSLTGNKKKARGNLTKLNLTATSKDGQEANNSAGKTIHRKACIAQQTFIVPDLVKILNTGRLTNFKIPLLKNKSEKRKEVNAKSSEREAYSPLELLDNLSGADVRQNRSKENVSMMMLGPQTLSIRNSVTPVQASSDSFYNKKSYSISPSFTKQGNNSKPSNHVSEPGNIVSNKEVASLTVENNAFSCDPGYVEKSPSFCCNEQETFRPVSSEVRGRKITKNFSEVGFPDILKAYEDDVLLIDVIQDDPDLFGVSNEGELSFTSEVPKISQEPNVAGEHQSTDSKYMETPVKKEPSDDLRELPVLDCGWIKPDICASNSAESEIKRDPKDVNTSLGEVANETSENETLGDFSEQIKGSDLDEKHRFTDKVITKEEKENIYEVCKSKDSRNADFMVGECQFAVPVPKPLCLLVPPLNLSGRQEDTILNTWMNDFRFLGKHSVLKLQNPETCEIFKREKNVGVFQKSLGLMIPYKYCKFHFNTLRGCERPLCKFAHVPEQGDEKVCMDVFKKYININELCLLQRAVNIFMEYYRKFPPGVYFDLQVLNDLLNSLLKHCLLKEVFQIVNLSIMVKMLPSLKILLNIFEYVATMKLRNAVPALIDIFCKLVEAGMVLDPEHFNYIVKLLYQVQASKQEITAVLEMKSRLQMRRFKKNWKCDLDSALNKLEHCKEKGDWTKLGKLYINVKMGCEKFADFQTFCACIAETLTKNYEDERPDIPFCEFAETVSKDPQNSKVDKGVLGRIGISAMYFYHKLLQWSKGRKVLEKLYELKIHFTSLKGLIGPEKLASRCQIVNVAAEIFLKSGSLDGAIWVMRESEWIINTPLWPCDRLDVLNRHNLLCTIAHEILAKSLYRQTFEVLQNLPGFQNSQETVEVSQYSLLFNKLLGSCIESSSLGMSSSVAEFMISKSIPIDFSFLRRLITSLGRSRLWLKARAHYKSALSLGCYPPLEGNLYRKLLLIPSYLSEIEMLLAIEIFMVSNASSIQSPGTSTQILQIVLKRCEDNQSRSNDDYQAAVERLIMAARISDPKLFVKHMTVNVNKEQVYSLEHCSALKWLKENMKWAGKVWLFSNH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	PPPLGPTTASGPEGN CCCCCCCCCCCCCCH	23.20	-
186	Phosphorylation	ENPPLKITENEATQN CCCCCCCCCCCCCCC	31.04	23403867
191	Phosphorylation	KITENEATQNIKVEF CCCCCCCCCCEEEEE	18.90	23403867
209	Phosphorylation	LYKNTPKYSCNILSP HHHCCCCCCCEECCC	21.47	25072903
210	Phosphorylation	YKNTPKYSCNILSPE HHCCCCCCCEECCCC	13.55	25072903
215	Phosphorylation	KYSCNILSPEVENNS CCCCEECCCCCCCCC	18.41	25072903
246	Phosphorylation	NDENNLPYKPDGGCM CCCCCCCCCCCCCCC	38.02	22461510
473	Phosphorylation	SSREDLRSASEELKL CCHHHHHHHHHHHHH	43.36	22617229
475	Phosphorylation	REDLRSASEELKLSC HHHHHHHHHHHHHHH	32.61	29255136
491	2-Hydroxyisobutyrylation	RTIPMTGKRTWPYYS EECCCCCCCCCCCCC	37.17	-
511	Phosphorylation	AWCWKKASLPESSYF HHHHHHCCCCCCCCC	54.02	-
515	Phosphorylation	KKASLPESSYFLRGS HHCCCCCCCCCCCCC	28.53	-
516	Phosphorylation	KASLPESSYFLRGSQ HCCCCCCCCCCCCCH	20.45	-
517	Phosphorylation	ASLPESSYFLRGSQE CCCCCCCCCCCCCHH	18.86	-
569	Phosphorylation	KEKLDSNSNCLSSVS HHHCCCCCCHHHHCC	32.64	-
573	Phosphorylation	DSNSNCLSSVSAVEP CCCCCHHHHCCCCCC	30.78	-
574	Phosphorylation	SNSNCLSSVSAVEPT CCCCHHHHCCCCCCC	13.72	-
645	Phosphorylation	KLNLTATSKDGQEAN EEEEEEECCCCHHHH	26.70	-
669	Phosphorylation	KACIAQQTFIVPDLV HHHHHCCEEEHHHHH	11.84	29396449
746	Phosphorylation	MLGPQTLSIRNSVTP EECCCEEEECCCCCC	23.92	24719451
752	Phosphorylation	LSIRNSVTPVQASSD EEECCCCCCCCCCCC	19.98	19276368
762	Phosphorylation	QASSDSFYNKKSYSI CCCCCCCCCCCCEEE	29.98	19276368
770	Phosphorylation	NKKSYSISPSFTKQG CCCCEEECCCCCCCC	14.46	-
772	Phosphorylation	KSYSISPSFTKQGNN CCEEECCCCCCCCCC	38.46	24719451
1002	Phosphorylation	KEEKENIYEVCKSKD HHHHHCHHHHHCCCC	17.56	27067055
1131	Methylation	KVCMDVFKKYININE HHHHHHHHHHCCHHH	44.51	-
1132	Methylation	VCMDVFKKYININEL HHHHHHHHHCCHHHH	39.64	-
1173	Phosphorylation	VLNDLLNSLLKHCLL HHHHHHHHHHHHHHH	34.74	24719451
1198	Phosphorylation	IMVKMLPSLKILLNI HHHHHHHHHHHHHHH	38.03	23403867
1370	Phosphorylation	RIGISAMYFYHKLLQ HHHHHHHHHHHHHHH	10.74	-
1372	Phosphorylation	GISAMYFYHKLLQWS HHHHHHHHHHHHHHH	4.79	-
1557	Phosphorylation	WLKARAHYKSALSLG HHHHHHHHHHHHHCC	12.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TOPZ1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TOPZ1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TOPZ1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TOPZ1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.