TOM70_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TOM70_RAT
• UniProt AC: Q75Q39
• Protein Name: Mitochondrial import receptor subunit TOM70
• Gene Name: Tomm70 {ECO:0000312|RGD:1303049}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 610
• Subcellular Localization: Mitochondrion outer membrane ; Single-pass membrane protein .
• Protein Description: Receptor that accelerates the import of all mitochondrial precursor proteins..
• Protein Sequence: MAASKPVEAAMAAAAAPASGNGVGSSGGTAAPGSGAGTLPRWHVALAIGAPLLLGAGAMYLWSRRRRRREAGGRGDASGLKRNSERKTPEGRASPALGSGPDGSGDSLEMSSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNADLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNEQSMLLADKVLKLLGKENAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAQGKYMAEALLLRATFYLLIGSANAAKPDLDKVISLKEANVKLRANALIKRGTMCMQQQQPMLSTQDFNMAAEIDPMNSDVYHHRGQLKILLDLVEEAVADFDACIRLRPKFALAQAQKCFALYRQAYTANNSSQVQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDKGLELISKAIEIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHAQTEVAKKYGLKPPTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAASKPVEA ------CCCCHHHHH	22.05	-
5	Acetylation	---MAASKPVEAAMA ---CCCCHHHHHHHH	48.64	25786129
74	Methylation	RRREAGGRGDASGLK HHHHHCCCCCHHHCC	38.61	-
88	Phosphorylation	KRNSERKTPEGRASP CCCCCCCCCCCCCCC	32.56	29779826
94	Phosphorylation	KTPEGRASPALGSGP CCCCCCCCCCCCCCC	14.89	23712012
99	Phosphorylation	RASPALGSGPDGSGD CCCCCCCCCCCCCCC	48.26	29779826
104	Phosphorylation	LGSGPDGSGDSLEMS CCCCCCCCCCCCCCC	46.97	27097102
107	Phosphorylation	GPDGSGDSLEMSSLD CCCCCCCCCCCCHHH	29.74	27097102
111	Phosphorylation	SGDSLEMSSLDRAQA CCCCCCCCHHHHHHH	20.55	27097102
112	Phosphorylation	GDSLEMSSLDRAQAA CCCCCCCHHHHHHHH	32.74	27097102
125	Acetylation	AAKNKGNKYFKAGKY HHHHHCCCCHHCCHH	61.81	22902405
187	Acetylation	KAVELNPKYVKALFR HHHHHCHHHHHHHHH	62.70	22902405
285	Succinylation	GEKSDEDKDKEGEAL CCCCCCCCCCCCCCE	69.52	26843850
435	Ubiquitination	ACIRLRPKFALAQAQ HHHHHCHHHHHHHHH	36.51	-
435	Acetylation	ACIRLRPKFALAQAQ HHHHHCHHHHHHHHH	36.51	22902405
472	Acetylation	KGFEEVIKKFPRCAE HCHHHHHHHCCCHHH	54.24	22902405
531	Ubiquitination	QWKQDLDKGLELISK HHHHCHHHHHHHHHH	73.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TOM70_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TOM70_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TOM70_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TOM70_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.