| UniProt ID | TOIP2_RAT | |
|---|---|---|
| UniProt AC | Q6P752 | |
| Protein Name | Torsin-1A-interacting protein 2 | |
| Gene Name | Tor1aip2 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 578 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass membrane protein. Nucleus envelope. |
|
| Protein Description | Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity (By similarity).. | |
| Protein Sequence | MSQTLKSQDTNMSDSGYRDPVEDSQNVLGNDPSVNSQAQDPIVTPSNTVEAQTLHPTSDLKEDHHEIGAKGQEHADTGDRAESSEEPALEKPPLDKAELERSPSSQDTEQRHHPYSEHVGGDTLVLDPNYSQSDLGGRADAHLESSSAAPTEGAGEGGEAGAHLESSCAALPVGADEGGRANAHLESSSAAPTEGAGEGGEADVHLESSSAVPPEEAHLESSSAAPSEGAGEGGEADAHLESSSAAPSEGAGEGGETAQNLLAVDSTDAQSPCHSSAGPGSQDSLRRRLPVTEAERHEEETQLVTEKEEVAQETLRKTEKKSLWTYGSMFLGCLIVAVVLSSVNSYYSSPAQQVPQNPALEAFLAQFSQLREKFPGQSAFLWQRGRKFLQKHLNASNPSEPATVIFTAAREGKETLKCLSYHVANAYTSSQKVTAVSIDGAERALQDSDTVKLLVDLELSYGFENGHKAAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEETLEASVSPRETEEKVRDLLWAKFTDSGTPSSFSHMDSDKLSGLWSRISHLVLPVQPVKNIEERGCLL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 24 | Phosphorylation | YRDPVEDSQNVLGND CCCCCCCCCCCCCCC | 15.33 | - | |
| 83 | Phosphorylation | DTGDRAESSEEPALE CCCCCCCCCCCCHHC | 41.90 | 30181290 | |
| 84 | Phosphorylation | TGDRAESSEEPALEK CCCCCCCCCCCHHCC | 37.17 | 30181290 | |
| 102 | Phosphorylation | DKAELERSPSSQDTE CHHHHCCCCCCCCHH | 21.54 | 29779826 | |
| 104 | Phosphorylation | AELERSPSSQDTEQR HHHCCCCCCCCHHHH | 41.71 | 22108457 | |
| 105 | Phosphorylation | ELERSPSSQDTEQRH HHCCCCCCCCHHHHC | 35.14 | 23984901 | |
| 108 | Phosphorylation | RSPSSQDTEQRHHPY CCCCCCCHHHHCCCC | 26.78 | 28432305 | |
| 115 | Phosphorylation | TEQRHHPYSEHVGGD HHHHCCCCCCCCCCC | 23.49 | 27097102 | |
| 116 | Phosphorylation | EQRHHPYSEHVGGDT HHHCCCCCCCCCCCE | 26.19 | 27097102 | |
| 123 | Phosphorylation | SEHVGGDTLVLDPNY CCCCCCCEEEECCCC | 23.26 | 27097102 | |
| 130 | Phosphorylation | TLVLDPNYSQSDLGG EEEECCCCCHHHCCC | 17.30 | 27097102 | |
| 131 | Phosphorylation | LVLDPNYSQSDLGGR EEECCCCCHHHCCCC | 29.83 | 27097102 | |
| 133 | Phosphorylation | LDPNYSQSDLGGRAD ECCCCCHHHCCCCCC | 28.94 | 27097102 | |
| 271 | Phosphorylation | VDSTDAQSPCHSSAG CCCCCCCCCCCCCCC | 31.08 | - | |
| 301 | Phosphorylation | AERHEEETQLVTEKE HHHHHHHHCHHHHHH | 30.40 | - | |
| 394 | N-linked_Glycosylation | KFLQKHLNASNPSEP HHHHHHHCCCCCCCC | 40.83 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TOIP2_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TOIP2_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TOIP2_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of TOIP2_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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