dbPTM

TOA1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TOA1_SCHPO
UniProt AC	Q9USU9
Protein Name	Transcription initiation factor IIA large subunit {ECO:0000250\|UniProtKB:P32773, ECO:0000312\|EMBL:CAB57938.1}
Gene Name	toa1 {ECO:0000250\|UniProtKB:P32773}
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	369
Subcellular Localization	Nucleus.
Protein Description	TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with tbp mediates transcriptional activity (By similarity)..
Protein Sequence	MSNSIVGEVYHHVILDVIANSRSDFEENGVDDATLRELQNLWQSKLVATDVATFPWAQAPVGTFPIGQLFDPVSGLRTDSLDVTAPAVANSPILNNIAAIRAVQQMDTFAQQHGNSNYYSPPTPSLPQSATNISFDSSAIPNVQSNPNNTAPFPSYSSNSLQLPTNQTADSPIINDHSTANVTSTGQEHAPDSSSTNSFGGLLLPNQNSPKKSELGETESSNTTPANSRNDVPQTDGAIHDLDDAGSPSNFESNRFAIAQKADAEIYEVLKKNRILQIDGTIEDNEDEKKPPVDTPSDEAINSDLDDPDSDEAPETEEGSDIGQAIVLCLYDKVNHHKNKWKCVFRDGVVGVNGKDYLFFKANGEFEWI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	Phosphorylation	DPVSGLRTDSLDVTA CCCCCCCCCCCCCCC	34.68	29996109
84	Phosphorylation	RTDSLDVTAPAVANS CCCCCCCCCCHHHCC	26.96	29996109
91	Phosphorylation	TAPAVANSPILNNIA CCCHHHCCCHHHHHH	11.99	25720772
213	Phosphorylation	NQNSPKKSELGETES CCCCCCCHHCCCCCC	44.15	29996109
218	Phosphorylation	KKSELGETESSNTTP CCHHCCCCCCCCCCC	39.09	29996109
220	Phosphorylation	SELGETESSNTTPAN HHCCCCCCCCCCCCC	35.99	29996109
221	Phosphorylation	ELGETESSNTTPANS HCCCCCCCCCCCCCC	31.78	29996109
223	Phosphorylation	GETESSNTTPANSRN CCCCCCCCCCCCCCC	35.78	29996109
224	Phosphorylation	ETESSNTTPANSRND CCCCCCCCCCCCCCC	25.34	25720772
247	Phosphorylation	HDLDDAGSPSNFESN CCCCCCCCCCCHHCC	27.20	28889911
249	Phosphorylation	LDDAGSPSNFESNRF CCCCCCCCCHHCCCC	56.71	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TOA1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TOA1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TOA1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TOA1_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TOA1_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-249, AND MASSSPECTROMETRY.	18257517 [Abstract]