TNR6B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNR6B_MOUSE
• UniProt AC: Q8BKI2
• Protein Name: Trinucleotide repeat-containing gene 6B protein
• Gene Name: Tnrc6b
• Organism: Mus musculus (Mouse).
• Sequence Length: 1810
• Subcellular Localization: Cytoplasm, P-body. Mammalian P-bodies are also known as GW bodies (GWBs)..
• Protein Description: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (By similarity)..
• Protein Sequence: MQTNEGEVEEESSSQVEQEDFVMEGHGKTPPPGEESKQEKEQEREEQLMEDKKRKKEDKKKKEATQKVTEQKTKVPEVTKPSLSQPTAASPIGSSPSPPVNGGNNAKRVAVPNGQPPSAARYMPREVPPRFRCQQDHKVLLKRGQPPPPSCMLLGGGAGPPPCTAPGANPNNNAQVTGALLQSESGTAPESTLGGAAASNYANSTWGPGASSNSGASPNPIHIWDKVIVDGSDMEEWPCIASKDTESSSENTTDNNSASNPGSEKSSLPGSTTSNKGKGSQCQAASSGNECNLGVWKSDPKAKSVQPPNSTSDSNNGLGNWRSTSGQDRIGPGSGFSNFNPNSNPSAWPALVQEGTSRKGALETESSSSSAQVSTVGQASREQQSKMENAGVNFVVSGREQAQIHNTDGPKNGNTNSLNLSSPNPMENKGMPFGMGLGNTSRSTDAPSQSTGDRKTGSVGSWGAARGPSGTDTVSGQSNSGNNGNNGKDREDSWKGASVPKPTGSKSDSWDNNNRSTGGSWNFGPQDNNDNKWGEGNKMTSGVSQGEWKQPTGSDELKIGEWSGPNQPNSSTGAWDNQKGHPLPENQGNAQAPCWGRSSSSAGSEVGGQSTGSNHKAGSSDSHNSGRRSYRPTHPDCQAVLQTLLSRTDLDPRVLSNTGWGQTQIKQDTVWDIEEVPRPEGKSDKGTEGWESAATQTKNSGGWGDAPSQSNQMKSGWGELSASTEWKDPKSTGGWNDYKNNNSSNWGGGRADEKTPSSWNESSCKDQGWGGGRQPNQGWTSGKNGWGEEVDQVKNNNWESSANKPVSGWGEGGQNEIGTWGNGGNTNLASKGGWEDCKRSPAWNETGRQPNSWNKQHQQQQQPPPPQPEASGSWGGPPPPPQGNVRPSNSNWSSGPQPTTPKDDEPSGWEEPSPQSISRKMDIDDGTSAWGDPNSYNYKNVNLWDKNSQGGPAPREPNLPTPMTGKSASVWSKSTPPAPDNGTSAWGEPNESSPGWGEMDDAGASTTGWGNTPANAPNAMKPNSKSMQDGWGESDGPVTGARHPSWEEEDDGGVWNTAGSQGSTSSHNSASWGQGGKKQMKCSLKGGNNDSWMNPLAKQFSNMGLLSQTEDNPSSKMDLSVDKKFDVDKRTMNLGDFNDIMRKDRPGFRPPNSKDLGTTDSGPYFEKGGSHGLFGNSTAQSRGLHTPVQPLSSSPGLRAQVPPQFISPQVSASMLKQFPNSGLNPGLFNVGPQLSPQQIAMLSQLPQIPQFQLACQLLLQQQQQQQQLLQNQRKISQAVRQQQEQQLARMVSALQQQQQQQQQQQRQPSMKHSPSHPVGPKPHLDNMVPNALNVGLPDLPTKGPIPGYGSGFSSGGMDYGMVGGKEAGTESRFKQWTSMMEGLPSVATQEATMHKNGAIVAPGKTRGGSPYNQFDIIPGDTLGGHTGPAGDSWLPAKSPPTNKIGSKSSNASWPPEFQPGVPWKGIQNIDPESDPYVTPGSVLGGTTTSPIVDTDHQLLRDNTTGSNSSLNTSLPSPGAWPYSASDNSFTNVHSTSAKFPDYKSTWSPDPIGHNPTHLSNKMWKNHISSRNTTPLTRPPPGLTNPKPASPWSSTAPRSVRGWGTQDSRIASASTWSDGGSVRPSYWLVLHNLTPQIDGSTLRTICMQHGPLLTFHLNLTQGTALIRYSTKQEAAKAQTALHMCVLGNTTILAEFATEDEVSRFLAQAQPPTPAATPSAPATGWQSLETSQNQADPVGPALNLFGGSTGLGQWSSSAGGSSGADLAGTSLWGPPNYSSSLWGVPTVEDPHRMGSPAPLLPGDLLGGGSDSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	Phosphorylation	LSQPTAASPIGSSPS CCCCCCCCCCCCCCC	18.00	28285833
94	Phosphorylation	TAASPIGSSPSPPVN CCCCCCCCCCCCCCC	39.53	25338131
95	Phosphorylation	AASPIGSSPSPPVNG CCCCCCCCCCCCCCC	24.96	28285833
97	Phosphorylation	SPIGSSPSPPVNGGN CCCCCCCCCCCCCCC	43.73	29514104
232	Phosphorylation	DKVIVDGSDMEEWPC EEEEECCCCCCCCCE	29.35	26525534
364	Phosphorylation	SRKGALETESSSSSA CCCCCEECCCCCCCC	41.85	25168779
366	Phosphorylation	KGALETESSSSSAQV CCCEECCCCCCCCEE	42.83	25168779
367	Phosphorylation	GALETESSSSSAQVS CCEECCCCCCCCEEE	28.18	25168779
368	Phosphorylation	ALETESSSSSAQVST CEECCCCCCCCEEEH	37.28	25168779
369	Phosphorylation	LETESSSSSAQVSTV EECCCCCCCCEEEHH	31.47	25168779
370	Phosphorylation	ETESSSSSAQVSTVG ECCCCCCCCEEEHHH	25.35	25168779
374	Phosphorylation	SSSSAQVSTVGQASR CCCCCEEEHHHHHHH	12.80	25168779
375	Phosphorylation	SSSAQVSTVGQASRE CCCCEEEHHHHHHHH	29.78	25168779
380	Phosphorylation	VSTVGQASREQQSKM EEHHHHHHHHHHHHH	28.58	25168779
421	Phosphorylation	NTNSLNLSSPNPMEN CCCCCCCCCCCCCCC	42.55	27087446
422	Phosphorylation	TNSLNLSSPNPMENK CCCCCCCCCCCCCCC	31.68	25263469
451	Phosphorylation	TDAPSQSTGDRKTGS CCCCCCCCCCCCCCC	35.15	-
456	Phosphorylation	QSTGDRKTGSVGSWG CCCCCCCCCCCCCCC	35.27	28066266
458	Phosphorylation	TGDRKTGSVGSWGAA CCCCCCCCCCCCCCC	28.65	26643407
461	Phosphorylation	RKTGSVGSWGAARGP CCCCCCCCCCCCCCC	21.85	28066266
507	Phosphorylation	PKPTGSKSDSWDNNN CCCCCCCCCCCCCCC	38.28	25338131
509	Phosphorylation	PTGSKSDSWDNNNRS CCCCCCCCCCCCCCC	43.34	23684622
594	Glutathionylation	QGNAQAPCWGRSSSS CCCCCCCCCCCCCCC	7.25	24333276
598	Phosphorylation	QAPCWGRSSSSAGSE CCCCCCCCCCCCCCC	30.54	27087446
599	Phosphorylation	APCWGRSSSSAGSEV CCCCCCCCCCCCCCC	27.27	27087446
600	Phosphorylation	PCWGRSSSSAGSEVG CCCCCCCCCCCCCCC	26.00	30352176
601	Phosphorylation	CWGRSSSSAGSEVGG CCCCCCCCCCCCCCC	38.30	30372032
604	Phosphorylation	RSSSSAGSEVGGQST CCCCCCCCCCCCCCC	28.91	27087446
610	Phosphorylation	GSEVGGQSTGSNHKA CCCCCCCCCCCCCCC	37.70	25195567
611	Phosphorylation	SEVGGQSTGSNHKAG CCCCCCCCCCCCCCC	36.42	29899451
613	Phosphorylation	VGGQSTGSNHKAGSS CCCCCCCCCCCCCCC	35.53	23684622
648	Phosphorylation	LQTLLSRTDLDPRVL HHHHHHCCCCCHHHH	37.22	28059163
758	Phosphorylation	ADEKTPSSWNESSCK CCCCCCCCCCHHHCC	34.81	23684622
840	Phosphorylation	GWEDCKRSPAWNETG CHHHHCCCCCCCCCC	12.40	23684622
899	Phosphorylation	WSSGPQPTTPKDDEP CCCCCCCCCCCCCCC	50.94	25338131
907	Phosphorylation	TPKDDEPSGWEEPSP CCCCCCCCCCCCCCC	55.26	25619855
913	Phosphorylation	PSGWEEPSPQSISRK CCCCCCCCCHHHCCC	38.56	25521595
916	Phosphorylation	WEEPSPQSISRKMDI CCCCCCHHHCCCCCC	26.39	25619855
918	Phosphorylation	EPSPQSISRKMDIDD CCCCHHHCCCCCCCC	30.97	25619855
1026	Phosphorylation	AMKPNSKSMQDGWGE CCCCCCCCCCCCCCC	22.84	25338131
1034	Phosphorylation	MQDGWGESDGPVTGA CCCCCCCCCCCCCCC	43.88	26525534
1039	Phosphorylation	GESDGPVTGARHPSW CCCCCCCCCCCCCCC	28.40	-
1045	Phosphorylation	VTGARHPSWEEEDDG CCCCCCCCCCCCCCC	40.78	23684622
1101	Phosphorylation	NPLAKQFSNMGLLSQ HHHHHHHCCCCCCCC	24.34	26643407
1161	Phosphorylation	KDLGTTDSGPYFEKG CCCCCCCCCCCCCCC	39.31	25367039
1164	Phosphorylation	GTTDSGPYFEKGGSH CCCCCCCCCCCCCCC	28.09	18563927
1192	Phosphorylation	HTPVQPLSSSPGLRA CCCCCCCCCCCCHHH	35.14	26643407
1193	Phosphorylation	TPVQPLSSSPGLRAQ CCCCCCCCCCCHHHC	48.51	25266776
1194	Phosphorylation	PVQPLSSSPGLRAQV CCCCCCCCCCHHHCC	21.44	26643407
1276	Phosphorylation	LQNQRKISQAVRQQQ HHHHHHHHHHHHHHH	18.34	-
1292	Phosphorylation	QQLARMVSALQQQQQ HHHHHHHHHHHHHHH	17.58	25338131
1313	Phosphorylation	RQPSMKHSPSHPVGP HCHHHHCCCCCCCCC	23.68	28418008
1315	Phosphorylation	PSMKHSPSHPVGPKP HHHHCCCCCCCCCCC	43.36	28066266
1405	Phosphorylation	AIVAPGKTRGGSPYN CEECCCCCCCCCCCC	40.22	26745281
1409	Phosphorylation	PGKTRGGSPYNQFDI CCCCCCCCCCCCCCC	27.34	21082442
1411	Phosphorylation	KTRGGSPYNQFDIIP CCCCCCCCCCCCCCC	24.24	21082442
1421	Phosphorylation	FDIIPGDTLGGHTGP CCCCCCCCCCCCCCC	32.97	25159016
1426	Phosphorylation	GDTLGGHTGPAGDSW CCCCCCCCCCCCCCC	48.40	25159016
1432	Phosphorylation	HTGPAGDSWLPAKSP CCCCCCCCCCCCCCC	29.60	25159016
1438	Phosphorylation	DSWLPAKSPPTNKIG CCCCCCCCCCCCCCC	37.91	22942356
1441	Phosphorylation	LPAKSPPTNKIGSKS CCCCCCCCCCCCCCC	53.15	26160508
1446	Phosphorylation	PPTNKIGSKSSNASW CCCCCCCCCCCCCCC	32.60	-
1473	Phosphorylation	IQNIDPESDPYVTPG CCCCCCCCCCCCCCC	49.64	29472430
1476	Phosphorylation	IDPESDPYVTPGSVL CCCCCCCCCCCCCCC	23.19	29472430
1478	Phosphorylation	PESDPYVTPGSVLGG CCCCCCCCCCCCCCC	18.98	26643407
1481	Phosphorylation	DPYVTPGSVLGGTTT CCCCCCCCCCCCCCC	18.51	26643407
1486	Phosphorylation	PGSVLGGTTTSPIVD CCCCCCCCCCCCCCC	25.71	26643407
1487	Phosphorylation	GSVLGGTTTSPIVDT CCCCCCCCCCCCCCC	28.66	26643407
1488	Phosphorylation	SVLGGTTTSPIVDTD CCCCCCCCCCCCCCC	32.13	26643407
1489	Phosphorylation	VLGGTTTSPIVDTDH CCCCCCCCCCCCCCC	15.55	26643407
1494	Phosphorylation	TTSPIVDTDHQLLRD CCCCCCCCCCHHHCC	25.20	26643407
1503	Phosphorylation	HQLLRDNTTGSNSSL CHHHCCCCCCCCCCC	36.50	29472430
1504	Phosphorylation	QLLRDNTTGSNSSLN HHHCCCCCCCCCCCC	44.88	29472430
1506	Phosphorylation	LRDNTTGSNSSLNTS HCCCCCCCCCCCCCC	31.29	29472430
1508	Phosphorylation	DNTTGSNSSLNTSLP CCCCCCCCCCCCCCC	37.59	29472430
1509	Phosphorylation	NTTGSNSSLNTSLPS CCCCCCCCCCCCCCC	29.86	29472430
1512	Phosphorylation	GSNSSLNTSLPSPGA CCCCCCCCCCCCCCC	36.61	29472430
1513	Phosphorylation	SNSSLNTSLPSPGAW CCCCCCCCCCCCCCC	36.89	29472430
1516	Phosphorylation	SLNTSLPSPGAWPYS CCCCCCCCCCCCCCC	41.06	29472430
1522	Phosphorylation	PSPGAWPYSASDNSF CCCCCCCCCCCCCCC	13.23	29472430
1523	Phosphorylation	SPGAWPYSASDNSFT CCCCCCCCCCCCCCC	19.74	29472430
1544	Phosphorylation	AKFPDYKSTWSPDPI CCCCCCCCCCCCCCC	28.95	26643407
1545	Phosphorylation	KFPDYKSTWSPDPIG CCCCCCCCCCCCCCC	26.30	26643407
1547	Phosphorylation	PDYKSTWSPDPIGHN CCCCCCCCCCCCCCC	21.36	25266776
1589	Phosphorylation	LTNPKPASPWSSTAP CCCCCCCCCCCCCCC	35.11	28066266
1592	Phosphorylation	PKPASPWSSTAPRSV CCCCCCCCCCCCCCC	22.61	26643407
1793	Phosphorylation	EDPHRMGSPAPLLPG CCCCCCCCCCCCCCC	14.46	26824392
1807	Phosphorylation	GDLLGGGSDSI---- CCCCCCCCCCC----	31.31	25159016
1809	Phosphorylation	LLGGGSDSI------ CCCCCCCCC------	31.71	25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNR6B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNR6B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNR6B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AGO2_MOUSE	Ago2	physical	19838187

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.