TNNT3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNNT3_RAT
• UniProt AC: P09739
• Protein Name: Troponin T, fast skeletal muscle
• Gene Name: Tnnt3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 259
• Protein Description: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity..
• Protein Sequence: MSDEETEQVEEQYEEEEEAQEEEVQEEAPEPEEVQEEEKPRPKLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELIALKERIEKRRAERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKILAERRKPLNIDHLSDDKLRDKAKELWDTLYQLETDKFEFGEKLKRQKYDITTLRSRIDQAQKHSKKAGATAKGKVGGRWK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDEETEQV ------CCHHHHHHH	54.45	22673903
2	Acetylation	------MSDEETEQV ------CCHHHHHHH	54.45	-
2 (in isoform 6)	Phosphorylation	-	54.45	22673903
2 (in isoform 7)	Phosphorylation	-	54.45	22673903
2 (in isoform 3)	Phosphorylation	-	54.45	22673903
78	Phosphorylation	ELQALIDSHFEARKK HHHHHHHHHHHHHHH	24.07	22673903
84	Acetylation	DSHFEARKKEEEELI HHHHHHHHHHHHHHH	72.14	22902405
85	Acetylation	SHFEARKKEEEELIA HHHHHHHHHHHHHHH	65.88	22902405
149	Phosphorylation	LKKKKALSSMGANYS HHHHHHHHHCCCCHH	24.12	22673903
150	Phosphorylation	KKKKALSSMGANYSS HHHHHHHHCCCCHHH	23.29	22673903
156	Phosphorylation	SSMGANYSSYLAKAD HHCCCCHHHHHHHHH	16.59	22673903
157	Phosphorylation	SMGANYSSYLAKADQ HCCCCHHHHHHHHHH	17.51	22673903
158	Phosphorylation	MGANYSSYLAKADQK CCCCHHHHHHHHHHH	12.53	22673903
185	Acetylation	KILAERRKPLNIDHL HHHHHHCCCCCCCCC	61.14	26302492
193	Phosphorylation	PLNIDHLSDDKLRDK CCCCCCCCCHHHHHH	40.10	22673903
196	Acetylation	IDHLSDDKLRDKAKE CCCCCCHHHHHHHHH	50.87	26302492
209	Phosphorylation	KELWDTLYQLETDKF HHHHHHHHHHHHCCC	17.10	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNNT3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNNT3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNNT3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TNNT3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.