TNNC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNNC2_HUMAN
• UniProt AC: P02585
• Protein Name: Troponin C, skeletal muscle
• Gene Name: TNNC2
• Organism: Homo sapiens (Human).
• Sequence Length: 160
• Protein Description: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments..
• Protein Sequence: MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDPEELAEIFRASGEHVTDEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTDQQAEAR ------CCHHHHHHH	42.38	978749
36	Phosphorylation	ADGGGDISVKELGTV CCCCCCEEHHHHHHH	31.69	24719451
38	Ubiquitination	GGGDISVKELGTVMR CCCCEEHHHHHHHHH	40.19	-
42	Phosphorylation	ISVKELGTVMRMLGQ EEHHHHHHHHHHHCC	24.61	26437602
45	Methylation	KELGTVMRMLGQTPT HHHHHHHHHHCCCCC	16.91	-
50	Phosphorylation	VMRMLGQTPTKEELD HHHHHCCCCCHHHHH	31.00	24719451
92	Phosphorylation	KEDAKGKSEEELAEC HHHHCCCCHHHHHHH	59.93	26437602
134	Phosphorylation	VTDEEIESLMKDGDK CCHHHHHHHHHHCCC	39.15	26437602

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNNC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNNC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNNC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNNI3_HUMAN	TNNI3	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB01023: Felodipine

Related Literatures of Post-Translational Modification

Acetylation

"Human skeletal muscle proteins. The primary structure of troponinC.";
Romero-Herrera A.E., Castillo O., Lehmann H.;
J. Mol. Evol. 8:251-270(1976).
Cited for: PROTEIN SEQUENCE OF 2-160.
PubMed: 978749