TNNC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNNC1_MOUSE
• UniProt AC: P19123
• Protein Name: Troponin C, slow skeletal and cardiac muscles
• Gene Name: Tnnc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 161
• Protein Description: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments..
• Protein Sequence: MDDIYKAAVEQLTEEQKNEFKAAFDIFVLGAEDGCISTKELGKVMRMLGQNPTPEELQEMIDEVDEDGSGTVDFDEFLVMMVRCMKDDSKGKSEEELSDLFRMFDKNADGYIDLDELKMMLQATGETITEDDIEELMKDGDKNNDGRIDYDEFLEFMKGVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDDIYKAA -------CHHHHHHH	10.62	-
6	Ubiquitination	--MDDIYKAAVEQLT --CHHHHHHHHHHHC	30.15	22790023
17	Ubiquitination	EQLTEEQKNEFKAAF HHHCHHHHHHHHHHH	62.82	22790023
35	S-nitrosocysteine	VLGAEDGCISTKELG HHCCCCCCCCHHHHH	3.25	-
35	S-nitrosylation	VLGAEDGCISTKELG HHCCCCCCCCHHHHH	3.25	21278135
39	Ubiquitination	EDGCISTKELGKVMR CCCCCCHHHHHHHHH	44.12	-
43	Acetylation	ISTKELGKVMRMLGQ CCHHHHHHHHHHHCC	45.54	2372279
43	Ubiquitination	ISTKELGKVMRMLGQ CCHHHHHHHHHHHCC	45.54	22790023
90	Ubiquitination	RCMKDDSKGKSEEEL HHHHCCCCCCCHHHH	76.87	22790023
92	Ubiquitination	MKDDSKGKSEEELSD HHCCCCCCCHHHHHH	59.43	22790023
93	Phosphorylation	KDDSKGKSEEELSDL HCCCCCCCHHHHHHH	59.93	27742792
98	Phosphorylation	GKSEEELSDLFRMFD CCCHHHHHHHHHHHH	35.23	24899341
106	Ubiquitination	DLFRMFDKNADGYID HHHHHHHCCCCCCCC	42.65	22790023
124	Phosphorylation	LKMMLQATGETITED HHHHHHHHCCCCCHH	23.69	25159016
127	Phosphorylation	MLQATGETITEDDIE HHHHHCCCCCHHHHH	34.25	25159016
129	Phosphorylation	QATGETITEDDIEEL HHHCCCCCHHHHHHH	40.56	25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNNC1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNNC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNNC1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TNNC1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.