TNIP1_MOUSE - dbPTM
TNIP1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TNIP1_MOUSE
UniProt AC Q9WUU8
Protein Name TNFAIP3-interacting protein 1
Gene Name Tnip1
Organism Mus musculus (Mouse).
Sequence Length 647
Subcellular Localization Cytoplasm. Nucleus. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner..
Protein Description Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases..
Protein Sequence MEGRGPYRIYDPGGSTPLGEVSAAFERLVEENTRLKGKMQGIKMLGELLEESQMEASRLRQKAEELVKDSELSPPTSAPSLVSFDDLAELTGQDTKVQVHPATSTAATTTATATTGNSMEKPEPASKSPSNGASSDFEVVPTEEQNSPETGSHPTNMMDLGPPPPEDSNLKLHLQRLETTLSVCAEEPDHSQLFTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRQENEALKAKLDKGLEQRDLAAERLREENTELKKLLMNSSCKEGLCGQPSSPKPEGAGKKGVAGQQQASVMASKVPEAGAFGAAEKKVKLLEQQRMELLEVNKQWDQHFRSMKQQYEQKITELRQKLVDLQKQVTELEAEREQKQRDFDRKLLLAKSKIEMEETDKEQLTAEAKELRQKVRYLQDQLSPLTRQREYQEKEIQRLNKALEEALSIQASPSSPPAAFGSPEGVGGHLRKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLTNAQLKTLKEEEKAKEALKQQKRKAKASGERYHMEPHPEHVCGAYPYAYPPMPAMVPHHAYKDWSQIRYPPPPVPMEHPPPHPNSRLFHLPEYTWRPPCAGIRNQSSQVMDPPPDRPAEPESADNDCDGPQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
70PhosphorylationAEELVKDSELSPPTS
HHHHHHCCCCCCCCC		34.4226745281
73PhosphorylationLVKDSELSPPTSAPS
HHHCCCCCCCCCCCC		25.4526745281
76PhosphorylationDSELSPPTSAPSLVS
CCCCCCCCCCCCCCC		40.6926745281
77PhosphorylationSELSPPTSAPSLVSF
CCCCCCCCCCCCCCH		43.9126745281
80PhosphorylationSPPTSAPSLVSFDDL
CCCCCCCCCCCHHHH		40.9126745281
83PhosphorylationTSAPSLVSFDDLAEL
CCCCCCCCHHHHHHH		28.4026745281
91PhosphorylationFDDLAELTGQDTKVQ
HHHHHHHHCCCCEEE		25.0526643407
103PhosphorylationKVQVHPATSTAATTT
EEEEECCCCCCCCCE		30.94-
103O-linked_GlycosylationKVQVHPATSTAATTT
EEEEECCCCCCCCCE		30.9422517741
108PhosphorylationPATSTAATTTATATT
CCCCCCCCCEEEECC		23.4022942356
109PhosphorylationATSTAATTTATATTG
CCCCCCCCEEEECCC		15.0923684622
112PhosphorylationTAATTTATATTGNSM
CCCCCEEEECCCCCC		23.5728066266
114PhosphorylationATTTATATTGNSMEK
CCCEEEECCCCCCCC		30.7728066266
115PhosphorylationTTTATATTGNSMEKP
CCEEEECCCCCCCCC		31.7228066266
118PhosphorylationATATTGNSMEKPEPA
EEECCCCCCCCCCCC		29.6626239621
126PhosphorylationMEKPEPASKSPSNGA
CCCCCCCCCCCCCCC		44.3626239621
147PhosphorylationVPTEEQNSPETGSHP
CCCCCCCCCCCCCCC		24.6525338131
223PhosphorylationQRTSILQTLCEQLRQ
HHHHHHHHHHHHHHH		29.90-
278PhosphorylationEGLCGQPSSPKPEGA
CCCCCCCCCCCCCCC		51.9227087446
279PhosphorylationGLCGQPSSPKPEGAG
CCCCCCCCCCCCCCC		43.5626824392
297PhosphorylationVAGQQQASVMASKVP
CCCHHHHHHHHHCCC		14.21-
349PhosphorylationQQYEQKITELRQKLV
HHHHHHHHHHHHHHH		35.6820469934
363PhosphorylationVDLQKQVTELEAERE
HHHHHHHHHHHHHHH		32.1521743459
416PhosphorylationRYLQDQLSPLTRQRE
HHHHHHCCHHHHHHH		16.5422942356
419PhosphorylationQDQLSPLTRQREYQE
HHHCCHHHHHHHHHH		28.3028066266
441PhosphorylationKALEEALSIQASPSS
HHHHHHHCCCCCCCC		21.5025619855
445PhosphorylationEALSIQASPSSPPAA
HHHCCCCCCCCCCHH		14.6725619855
447PhosphorylationLSIQASPSSPPAAFG
HCCCCCCCCCCHHHC		53.6425619855
448PhosphorylationSIQASPSSPPAAFGS
CCCCCCCCCCHHHCC		37.9826824392
455PhosphorylationSPPAAFGSPEGVGGH
CCCHHHCCCCCCCHH		17.2126824392
565PhosphorylationCGAYPYAYPPMPAMV
CCCCCCCCCCCCCCC		11.30-
584MethylationYKDWSQIRYPPPPVP
CCCHHHCCCCCCCCC		30.2124129315
584Asymmetric dimethylarginineYKDWSQIRYPPPPVP
CCCHHHCCCCCCCCC		30.21-
612Asymmetric dimethylarginineHLPEYTWRPPCAGIR
CCCCCCCCCCCCCCC		19.92-
612MethylationHLPEYTWRPPCAGIR
CCCCCCCCCCCCCCC		19.92-
623 (in isoform 3)Phosphorylation-19.6125338131
638PhosphorylationDRPAEPESADNDCDG
CCCCCCCCCCCCCCC		52.19-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TNIP1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TNIP1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TNIP1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TNIP1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TNIP1_MOUSE

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Related Literatures of Post-Translational Modification

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