UniProt ID | TNIP1_MOUSE | |
---|---|---|
UniProt AC | Q9WUU8 | |
Protein Name | TNFAIP3-interacting protein 1 | |
Gene Name | Tnip1 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 647 | |
Subcellular Localization | Cytoplasm. Nucleus. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.. | |
Protein Description | Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases.. | |
Protein Sequence | MEGRGPYRIYDPGGSTPLGEVSAAFERLVEENTRLKGKMQGIKMLGELLEESQMEASRLRQKAEELVKDSELSPPTSAPSLVSFDDLAELTGQDTKVQVHPATSTAATTTATATTGNSMEKPEPASKSPSNGASSDFEVVPTEEQNSPETGSHPTNMMDLGPPPPEDSNLKLHLQRLETTLSVCAEEPDHSQLFTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRQENEALKAKLDKGLEQRDLAAERLREENTELKKLLMNSSCKEGLCGQPSSPKPEGAGKKGVAGQQQASVMASKVPEAGAFGAAEKKVKLLEQQRMELLEVNKQWDQHFRSMKQQYEQKITELRQKLVDLQKQVTELEAEREQKQRDFDRKLLLAKSKIEMEETDKEQLTAEAKELRQKVRYLQDQLSPLTRQREYQEKEIQRLNKALEEALSIQASPSSPPAAFGSPEGVGGHLRKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLTNAQLKTLKEEEKAKEALKQQKRKAKASGERYHMEPHPEHVCGAYPYAYPPMPAMVPHHAYKDWSQIRYPPPPVPMEHPPPHPNSRLFHLPEYTWRPPCAGIRNQSSQVMDPPPDRPAEPESADNDCDGPQ | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
70 | Phosphorylation | AEELVKDSELSPPTS HHHHHHCCCCCCCCC | 34.42 | 26745281 | |
73 | Phosphorylation | LVKDSELSPPTSAPS HHHCCCCCCCCCCCC | 25.45 | 26745281 | |
76 | Phosphorylation | DSELSPPTSAPSLVS CCCCCCCCCCCCCCC | 40.69 | 26745281 | |
77 | Phosphorylation | SELSPPTSAPSLVSF CCCCCCCCCCCCCCH | 43.91 | 26745281 | |
80 | Phosphorylation | SPPTSAPSLVSFDDL CCCCCCCCCCCHHHH | 40.91 | 26745281 | |
83 | Phosphorylation | TSAPSLVSFDDLAEL CCCCCCCCHHHHHHH | 28.40 | 26745281 | |
91 | Phosphorylation | FDDLAELTGQDTKVQ HHHHHHHHCCCCEEE | 25.05 | 26643407 | |
103 | Phosphorylation | KVQVHPATSTAATTT EEEEECCCCCCCCCE | 30.94 | - | |
103 | O-linked_Glycosylation | KVQVHPATSTAATTT EEEEECCCCCCCCCE | 30.94 | 22517741 | |
108 | Phosphorylation | PATSTAATTTATATT CCCCCCCCCEEEECC | 23.40 | 22942356 | |
109 | Phosphorylation | ATSTAATTTATATTG CCCCCCCCEEEECCC | 15.09 | 23684622 | |
112 | Phosphorylation | TAATTTATATTGNSM CCCCCEEEECCCCCC | 23.57 | 28066266 | |
114 | Phosphorylation | ATTTATATTGNSMEK CCCEEEECCCCCCCC | 30.77 | 28066266 | |
115 | Phosphorylation | TTTATATTGNSMEKP CCEEEECCCCCCCCC | 31.72 | 28066266 | |
118 | Phosphorylation | ATATTGNSMEKPEPA EEECCCCCCCCCCCC | 29.66 | 26239621 | |
126 | Phosphorylation | MEKPEPASKSPSNGA CCCCCCCCCCCCCCC | 44.36 | 26239621 | |
147 | Phosphorylation | VPTEEQNSPETGSHP CCCCCCCCCCCCCCC | 24.65 | 25338131 | |
223 | Phosphorylation | QRTSILQTLCEQLRQ HHHHHHHHHHHHHHH | 29.90 | - | |
278 | Phosphorylation | EGLCGQPSSPKPEGA CCCCCCCCCCCCCCC | 51.92 | 27087446 | |
279 | Phosphorylation | GLCGQPSSPKPEGAG CCCCCCCCCCCCCCC | 43.56 | 26824392 | |
297 | Phosphorylation | VAGQQQASVMASKVP CCCHHHHHHHHHCCC | 14.21 | - | |
349 | Phosphorylation | QQYEQKITELRQKLV HHHHHHHHHHHHHHH | 35.68 | 20469934 | |
363 | Phosphorylation | VDLQKQVTELEAERE HHHHHHHHHHHHHHH | 32.15 | 21743459 | |
416 | Phosphorylation | RYLQDQLSPLTRQRE HHHHHHCCHHHHHHH | 16.54 | 22942356 | |
419 | Phosphorylation | QDQLSPLTRQREYQE HHHCCHHHHHHHHHH | 28.30 | 28066266 | |
441 | Phosphorylation | KALEEALSIQASPSS HHHHHHHCCCCCCCC | 21.50 | 25619855 | |
445 | Phosphorylation | EALSIQASPSSPPAA HHHCCCCCCCCCCHH | 14.67 | 25619855 | |
447 | Phosphorylation | LSIQASPSSPPAAFG HCCCCCCCCCCHHHC | 53.64 | 25619855 | |
448 | Phosphorylation | SIQASPSSPPAAFGS CCCCCCCCCCHHHCC | 37.98 | 26824392 | |
455 | Phosphorylation | SPPAAFGSPEGVGGH CCCHHHCCCCCCCHH | 17.21 | 26824392 | |
565 | Phosphorylation | CGAYPYAYPPMPAMV CCCCCCCCCCCCCCC | 11.30 | - | |
584 | Methylation | YKDWSQIRYPPPPVP CCCHHHCCCCCCCCC | 30.21 | 24129315 | |
584 | Asymmetric dimethylarginine | YKDWSQIRYPPPPVP CCCHHHCCCCCCCCC | 30.21 | - | |
612 | Asymmetric dimethylarginine | HLPEYTWRPPCAGIR CCCCCCCCCCCCCCC | 19.92 | - | |
612 | Methylation | HLPEYTWRPPCAGIR CCCCCCCCCCCCCCC | 19.92 | - | |
623 (in isoform 3) | Phosphorylation | - | 19.61 | 25338131 | |
638 | Phosphorylation | DRPAEPESADNDCDG CCCCCCCCCCCCCCC | 52.19 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TNIP1_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TNIP1_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TNIP1_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of TNIP1_MOUSE !! |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
loading...