| UniProt ID | TMOD1_MOUSE | |
|---|---|---|
| UniProt AC | P49813 | |
| Protein Name | Tropomodulin-1 | |
| Gene Name | Tmod1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 359 | |
| Subcellular Localization | Cytoplasm, cytoskeleton . In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments. | |
| Protein Description | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).. | |
| Protein Sequence | MSYRRELEKYRDLDEDEILGALTEEELRTLENELDELDPDNALLPAGLRQKDQTTKAPTGPFKREELLDHLEKQAKEFKDREDLVPYTGEKRGKVWVPKQKPMDPVLESVTLEPELEEALANASDAELCDIAAILGMHTLMSNQQYYQALGSSSIVNKEGLNSVIKPTQYKPVPDEEPNSTDVEETLERIKNNDPELEEVNLNNIRNIPIPTLKAYAEALKENSYVKKFSIVGTRSNDPVAFALAEMLKVNKVLKTLNVESNFISGAGILRLVEALPHNTSLVELKIDNQSQPLGNKVEMEIVNMLEKNTTLLKFGYHFTQQGPRLRASNAMMSNNDLVRKRRLADLTGPIIPKCRSGV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 54 | Phosphorylation | GLRQKDQTTKAPTGP HHCCCCCCCCCCCCC | 40.16 | - | |
| 59 | Phosphorylation | DQTTKAPTGPFKREE CCCCCCCCCCCCHHH | 63.45 | 22006019 | |
| 91 | Ubiquitination | LVPYTGEKRGKVWVP CCCCCCCCCCEEEEC | 68.73 | 22790023 | |
| 228 | Ubiquitination | KENSYVKKFSIVGTR HHCCCEEEEEEEECC | 34.01 | 22790023 | |
| 280 | Phosphorylation | VEALPHNTSLVELKI HHHCCCCCCEEEEEE | 22.02 | 28833060 | |
| 281 | Phosphorylation | EALPHNTSLVELKID HHCCCCCCEEEEEEC | 35.42 | 28833060 | |
| 354 | Ubiquitination | LTGPIIPKCRSGV-- CCCCCCHHCCCCC-- | 31.69 | 22790023 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TMOD1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TMOD1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TMOD1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of TMOD1_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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