TMM64_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMM64_HUMAN
• UniProt AC: Q6YI46
• Protein Name: Transmembrane protein 64
• Gene Name: TMEM64
• Organism: Homo sapiens (Human).
• Sequence Length: 380
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Endoplasmic reticulum .
• Protein Description: Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1..
• Protein Sequence: MRSPGGILLQALPRLLQHAALPGLAELPARWALPRGAGGDGPADRLPRGGGASAAAAAAAASGALLGAYLERHGPPEASELPEPGGALAGGPGSGGGGVVVGVAEVRNWRCCCLGSTCWCRSLVLVCVLAALCFASLALVRRYLHHLLLWVESLDSLLGVLLFVVGFIVVSFPCGWGYIVLNVAAGYLYGFVLGMGLMMVGVLIGTFIAHVVCKRLLTAWVAARIQSSEKLSAVIRVVEGGSGLKVVALARLTPIPFGLQNAVFSITDLSLPNYLMASSVGLLPTQLLNSYLGTTLRTMEDVIAEQSVSGYFVFCLQIIISIGLMFYVVHRAQVELNAAIVACEMELKSSLVKGNQPNTSGSSFYNKRTLTFSGGGINVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36 (in isoform 2)	Ubiquitination	-	27.00	21906983
51 (in isoform 2)	Ubiquitination	-	21.12	21906983
53	Phosphorylation	LPRGGGASAAAAAAA CCCCCHHHHHHHHHH	23.01	-
69	Phosphorylation	SGALLGAYLERHGPP HHHHHHHHHHHHCCC	13.80	27642862
159 (in isoform 2)	Ubiquitination	-	17.20	21906983
173 (in isoform 2)	Ubiquitination	-	14.27	21906983
230 (in isoform 1)	Ubiquitination	-	50.09	21906983
230	Ubiquitination	ARIQSSEKLSAVIRV HHHCCCCCCCEEEEE	50.09	33845483
245 (in isoform 1)	Ubiquitination	-	37.88	21906983
245	Ubiquitination	VEGGSGLKVVALARL EECCCCCEEEEEEEC	37.88	21906983
301	Ubiquitination	TTLRTMEDVIAEQSV CCCCCHHHHHHHCCC	26.71	21963094
315	Ubiquitination	VSGYFVFCLQIIISI CCHHHHHHHHHHHHH	1.99	27667366
353 (in isoform 1)	Ubiquitination	-	58.39	21906983
353	Ubiquitination	ELKSSLVKGNQPNTS HHHHHHHCCCCCCCC	58.39	21906983
367 (in isoform 1)	Ubiquitination	-	35.07	21906983
367	Ubiquitination	SGSSFYNKRTLTFSG CCCCCCCCCEEEEEC	35.07	27667366
369	Phosphorylation	SSFYNKRTLTFSGGG CCCCCCCEEEEECCC	31.59	-
371	Phosphorylation	FYNKRTLTFSGGGIN CCCCCEEEEECCCEE	18.36	24719451
373	Phosphorylation	NKRTLTFSGGGINVV CCCEEEEECCCEECC	31.15	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMM64_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMM64_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMM64_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TMM64_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.