TMK1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMK1_ARATH
• UniProt AC: P43298
• Protein Name: Receptor protein kinase TMK1 {ECO:0000303|PubMed:1332795}
• Gene Name: TMK1 {ECO:0000303|PubMed:1332795}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 942
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Transmembrane kinase receptor. [PubMed: 1332795 Phosphorylates only serine and threonine residues]
• Protein Sequence: MKKRRTFLLFSFTFLLLLSLSKADSDGDLSAMLSLKKSLNPPSSFGWSDPDPCKWTHIVCTGTKRVTRIQIGHSGLQGTLSPDLRNLSELERLELQWNNISGPVPSLSGLASLQVLMLSNNNFDSIPSDVFQGLTSLQSVEIDNNPFKSWEIPESLRNASALQNFSANSANVSGSLPGFLGPDEFPGLSILHLAFNNLEGELPMSLAGSQVQSLWLNGQKLTGDITVLQNMTGLKEVWLHSNKFSGPLPDFSGLKELESLSLRDNSFTGPVPASLLSLESLKVVNLTNNHLQGPVPVFKSSVSVDLDKDSNSFCLSSPGECDPRVKSLLLIASSFDYPPRLAESWKGNDPCTNWIGIACSNGNITVISLEKMELTGTISPEFGAIKSLQRIILGINNLTGMIPQELTTLPNLKTLDVSSNKLFGKVPGFRSNVVVNTNGNPDIGKDKSSLSSPGSSSPSGGSGSGINGDKDRRGMKSSTFIGIIVGSVLGGLLSIFLIGLLVFCWYKKRQKRFSGSESSNAVVVHPRHSGSDNESVKITVAGSSVSVGGISDTYTLPGTSEVGDNIQMVEAGNMLISIQVLRSVTNNFSSDNILGSGGFGVVYKGELHDGTKIAVKRMENGVIAGKGFAEFKSEIAVLTKVRHRHLVTLLGYCLDGNEKLLVYEYMPQGTLSRHLFEWSEEGLKPLLWKQRLTLALDVARGVEYLHGLAHQSFIHRDLKPSNILLGDDMRAKVADFGLVRLAPEGKGSIETRIAGTFGYLAPEYAVTGRVTTKVDVYSFGVILMELITGRKSLDESQPEESIHLVSWFKRMYINKEASFKKAIDTTIDLDEETLASVHTVAELAGHCCAREPYQRPDMGHAVNILSSLVELWKPSDQNPEDIYGIDLDMSLPQALKKWQAYEGRSDLESSTSSLLPSLDNTQMSIPTRPYGFAESFTSVDGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	N-linked_Glycosylation	TLSPDLRNLSELERL CCCCCCCCHHHHHHH	56.04	-
99	N-linked_Glycosylation	RLELQWNNISGPVPS HHHHHHCCCCCCCCC	27.18	-
112	Phosphorylation	PSLSGLASLQVLMLS CCHHHHHHHHHHHCC	25.11	28011693
158	N-linked_Glycosylation	EIPESLRNASALQNF CCCHHHCCHHHHHHC	43.47	23147790
164	N-linked_Glycosylation	RNASALQNFSANSAN CCHHHHHHCCCCCCC	33.42	-
171	N-linked_Glycosylation	NFSANSANVSGSLPG HCCCCCCCCCCCCCC	28.45	-
230	N-linked_Glycosylation	GDITVLQNMTGLKEV CCEEEEECCCCCCEE	26.31	-
285	N-linked_Glycosylation	LESLKVVNLTNNHLQ HHCCEEEECCCCCCC	44.10	23147790
301	Phosphorylation	PVPVFKSSVSVDLDK CCCEEECEEEEEECC	20.99	28011693
303	Phosphorylation	PVFKSSVSVDLDKDS CEEECEEEEEECCCC	16.32	28011693
363	N-linked_Glycosylation	GIACSNGNITVISLE EEEECCCCEEEEEEE	30.89	-
397	N-linked_Glycosylation	RIILGINNLTGMIPQ HHHHCHHHCCCCCCH	36.74	-
452	Phosphorylation	KDKSSLSSPGSSSPS CCHHHCCCCCCCCCC	38.28	19880383
455	Phosphorylation	SSLSSPGSSSPSGGS HHCCCCCCCCCCCCC	30.90	19880383
514	Phosphorylation	KKRQKRFSGSESSNA HHHHHCCCCCCCCCC	45.50	29654922
516	Phosphorylation	RQKRFSGSESSNAVV HHHCCCCCCCCCCEE	32.86	27532006
518	Phosphorylation	KRFSGSESSNAVVVH HCCCCCCCCCCEEEC	30.50	30291188
519	Phosphorylation	RFSGSESSNAVVVHP CCCCCCCCCCEEECC	25.42	27532006
529	Phosphorylation	VVVHPRHSGSDNESV EEECCCCCCCCCCCE	41.07	25561503
531	Phosphorylation	VHPRHSGSDNESVKI ECCCCCCCCCCCEEE	40.03	25561503
544	Phosphorylation	KITVAGSSVSVGGIS EEEECCCEEEECCCC	19.93	28011693
546	Phosphorylation	TVAGSSVSVGGISDT EECCCEEEECCCCCC	19.59	28011693

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMK1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMK1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMK1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GDU4_ARATH	GDU4	physical	22737156

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.