TMCC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMCC3_HUMAN
• UniProt AC: Q9ULS5
• Protein Name: Transmembrane and coiled-coil domain protein 3
• Gene Name: TMCC3
• Organism: Homo sapiens (Human).
• Sequence Length: 477
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MPGSDTALTVDRTYSYPGRHHRCKSRVERHDMNTLSLPLNIRRGGSDTNLNFDVPDGILDFHKVKLTADSLKQKILKVTEQIKIEQTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKNQKSAHSIAQLQKKLEQYHRKLREIEQNGASRSSKDISKDHLKDIHRSLKDAHVKSRTAPHCMESSKSGMPGVSLTPPVFVFNKSREFANLIRNKFGSADNIAHLKNSLEEFRPEASARAYGGSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLDSQGKLAVILEELREIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTDLHQHETANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQALQTDTVNAKVLLGRCINVILAFMTVILVCVSTIAKFVSPMMKSRCHILGTFFAVTLLAIFCKNWDHILCAIERMIIPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPGSDTALTVD ----CCCCCCCEECC	26.39	28355574
6	Phosphorylation	--MPGSDTALTVDRT --CCCCCCCEECCCC	25.84	22617229
9	Phosphorylation	PGSDTALTVDRTYSY CCCCCCEECCCCCCC	20.21	27486199
14	Phosphorylation	ALTVDRTYSYPGRHH CEECCCCCCCCCCCC	13.70	24719451
15	Phosphorylation	LTVDRTYSYPGRHHR EECCCCCCCCCCCCC	25.00	24719451
34	Phosphorylation	VERHDMNTLSLPLNI HHHCCCCCCCCCCEE	15.87	23403867
36	Phosphorylation	RHDMNTLSLPLNIRR HCCCCCCCCCCEECC	26.38	23403867
46	Phosphorylation	LNIRRGGSDTNLNFD CEECCCCCCCCCCCC	44.05	22617229
48	Phosphorylation	IRRGGSDTNLNFDVP ECCCCCCCCCCCCCC	43.21	23403867
122	Phosphorylation	FEKKNQKSAHSIAQL HHHHCHHHHHHHHHH	22.81	27794612
125	Phosphorylation	KNQKSAHSIAQLQKK HCHHHHHHHHHHHHH	21.24	27794612
149	Phosphorylation	EIEQNGASRSSKDIS HHHHCCCCCCCCCCC	33.81	29514088
151	Phosphorylation	EQNGASRSSKDISKD HHCCCCCCCCCCCHH	38.96	29514088
152	Phosphorylation	QNGASRSSKDISKDH HCCCCCCCCCCCHHH	32.98	29514088
166	Phosphorylation	HLKDIHRSLKDAHVK HHHHHHHHHHHHHHH	26.13	24719451
174	Phosphorylation	LKDAHVKSRTAPHCM HHHHHHHCCCCCCHH	33.50	28857561
176	Phosphorylation	DAHVKSRTAPHCMES HHHHHCCCCCCHHHC	52.19	28857561
183	Phosphorylation	TAPHCMESSKSGMPG CCCCHHHCCCCCCCC	19.04	27794612
184	Phosphorylation	APHCMESSKSGMPGV CCCHHHCCCCCCCCC	19.96	27794612
192	Phosphorylation	KSGMPGVSLTPPVFV CCCCCCCCCCCCEEE	32.23	27732954
194	Phosphorylation	GMPGVSLTPPVFVFN CCCCCCCCCCEEEEC	20.31	23403867
216	Phosphorylation	LIRNKFGSADNIAHL HHHHHHCCHHHHHHH	35.27	26846344
226	Phosphorylation	NIAHLKNSLEEFRPE HHHHHHHHHHHHCHH	35.25	28355574
235	Phosphorylation	EEFRPEASARAYGGS HHHCHHHHHHHHCCC	19.34	27794612
239	Phosphorylation	PEASARAYGGSATIV HHHHHHHHCCCEEEE	19.23	23403867
242	Phosphorylation	SARAYGGSATIVNKP HHHHHCCCEEEECCC	20.20	28176443
244	Phosphorylation	RAYGGSATIVNKPKY HHHCCCEEEECCCCC	27.44	23403867
251	Phosphorylation	TIVNKPKYGSDDECS EEECCCCCCCCCCCC	30.32	27251275
253	Phosphorylation	VNKPKYGSDDECSSG ECCCCCCCCCCCCCC	38.51	26471730
258	Phosphorylation	YGSDDECSSGTSGSA CCCCCCCCCCCCCCC	29.74	27251275
259	Phosphorylation	GSDDECSSGTSGSAD CCCCCCCCCCCCCCC	58.72	27251275
261	Phosphorylation	DDECSSGTSGSADSN CCCCCCCCCCCCCCC	31.68	27251275
262	Phosphorylation	DECSSGTSGSADSNG CCCCCCCCCCCCCCC	33.99	27251275
264	Phosphorylation	CSSGTSGSADSNGNQ CCCCCCCCCCCCCCC	28.77	27251275
267	Phosphorylation	GTSGSADSNGNQSFG CCCCCCCCCCCCCCC	46.48	27251275
272	Phosphorylation	ADSNGNQSFGAGGAS CCCCCCCCCCCCCCC	29.64	27251275
280	Phosphorylation	FGAGGASTLDSQGKL CCCCCCCCCCCCCCH	33.77	-
385	Phosphorylation	EALESCQTRISKLEL HHHHHHHHHHHHHHH	34.01	-
402	Phosphorylation	QEQQALQTDTVNAKV HHHHHHCCCCCCHHH	34.19	24043423
404	Phosphorylation	QQALQTDTVNAKVLL HHHHCCCCCCHHHHH	21.03	24043423
437	Phosphorylation	STIAKFVSPMMKSRC HHHHHHHCHHHHHHC	15.37	23879269

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMCC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMCC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMCC3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TMCC3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.