TM7S3_HUMAN - dbPTM
TM7S3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TM7S3_HUMAN
UniProt AC Q9NS93
Protein Name Transmembrane 7 superfamily member 3
Gene Name TM7SF3
Organism Homo sapiens (Human).
Sequence Length 570
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells. [PubMed: 21853325 Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR)]
Protein Sequence MGFLQLLVVAVLASEHRVAGAAEVFGNSSEGLIEFSVGKFRYFELNRPFPEEAILHDISSNVTFLIFQIHSQYQNTTVSFSPTLLSNSSETGTASGLVFILRPEQSTCTWYLGTSGIQPVQNMAILLSYSERDPVPGGCNLEFDLDIDPNIYLEYNFFETTIKFAPANLGYARGVDPPPCDAGTDQDSRWRLQYDVYQYFLPENDLTEEMLLKHLQRMVSVPQVKASALKVVTLTANDKTSVSFSSLPGQGVIYNVIVWDPFLNTSAAYIPAHTYACSFEAGEGSCASLGRVSSKVFFTLFALLGFFICFFGHRFWKTELFFIGFIIMGFFFYILITRLTPIKYDVNLILTAVTGSVGGMFLVAVWWRFGILSICMLCVGLVLGFLISSVTFFTPLGNLKIFHDDGVFWVTFSCIAILIPVVFMGCLRILNILTCGVIGSYSVVLAIDSYWSTSLSYITLNVLKRALNKDFHRAFTNVPFQTNDFIILAVWGMLAVSGITLQIRRERGRPFFPPHPYKLWKQERERRVTNILDPSYHIPPLRERLYGRLTQIKGLFQKEQPAGERTPLLL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
27N-linked_GlycosylationGAAEVFGNSSEGLIE
CEEEHHCCCCCCEEE		30.78UniProtKB CARBOHYD
61N-linked_GlycosylationILHDISSNVTFLIFQ
HHHHHHCCCEEEEEE		30.02UniProtKB CARBOHYD
75N-linked_GlycosylationQIHSQYQNTTVSFSP
EEEECCCCCEEEECC		32.55UniProtKB CARBOHYD
87N-linked_GlycosylationFSPTLLSNSSETGTA
ECCEECCCCCCCCCC		49.91UniProtKB CARBOHYD
91UbiquitinationLLSNSSETGTASGLV
ECCCCCCCCCCEEEE		41.6021963094
111UbiquitinationEQSTCTWYLGTSGIQ
CCCEEEEEECCCCCC		4.1521963094
152PhosphorylationLDIDPNIYLEYNFFE
ECCCCCEEEEEEEEC		10.5022468782
155PhosphorylationDPNIYLEYNFFETTI
CCCEEEEEEEECCEE		18.0622468782
213UbiquitinationLTEEMLLKHLQRMVS
CCHHHHHHHHHHHCC		38.0021963094
225UbiquitinationMVSVPQVKASALKVV
HCCCHHHHHCEEEEE		31.23-
227PhosphorylationSVPQVKASALKVVTL
CCHHHHHCEEEEEEE		28.54-
243UbiquitinationANDKTSVSFSSLPGQ
CCCCCEEEEECCCCC		21.1221963094
264N-linked_GlycosylationIVWDPFLNTSAAYIP
EEECCCCCCCCEECC		32.16UniProtKB CARBOHYD
380UbiquitinationSICMLCVGLVLGFLI
HHHHHHHHHHHHHHH		14.7423000965
385UbiquitinationCVGLVLGFLISSVTF
HHHHHHHHHHHHCCE		4.8423000965
400UbiquitinationFTPLGNLKIFHDDGV
ECCCCCEEEEECCCC		47.5323000965
405UbiquitinationNLKIFHDDGVFWVTF
CEEEEECCCCCHHHH		46.7323000965
431UbiquitinationMGCLRILNILTCGVI
HHHHHHHHHHHCCCC		25.5023000965
436UbiquitinationILNILTCGVIGSYSV
HHHHHHCCCCCCEEE		14.6123000965
451UbiquitinationVLAIDSYWSTSLSYI
EEEEECCCCCCHHHH		10.0923000965
456UbiquitinationSYWSTSLSYITLNVL
CCCCCCHHHHHHHHH		17.7923000965
502UbiquitinationAVSGITLQIRRERGR
HHCCCEEHHHHHCCC		20.6323000965
507UbiquitinationTLQIRRERGRPFFPP
EEHHHHHCCCCCCCC		44.6123000965
521UbiquitinationPHPYKLWKQERERRV
CCHHHHHHHHHHHHH		53.36-
529PhosphorylationQERERRVTNILDPSY
HHHHHHHHCCCCCHH		18.0921945579
535PhosphorylationVTNILDPSYHIPPLR
HHCCCCCHHCCCCHH		29.0721945579
536PhosphorylationTNILDPSYHIPPLRE
HCCCCCHHCCCCHHH		14.7921945579
546PhosphorylationPPLRERLYGRLTQIK
CCHHHHHHHHHHHHH		13.3524719451
553UbiquitinationYGRLTQIKGLFQKEQ
HHHHHHHHHHHHCCC		39.4823000965
558UbiquitinationQIKGLFQKEQPAGER
HHHHHHHCCCCCCCC		51.4823000965
566PhosphorylationEQPAGERTPLLL---
CCCCCCCCCCCC---		17.6230266825
583Ubiquitination--------------------
--------------------		23000965
588Ubiquitination-------------------------
-------------------------		23000965
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TM7S3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TM7S3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TM7S3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TM7S3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TM7S3_HUMAN

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Related Literatures of Post-Translational Modification

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