TM2D1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM2D1_HUMAN
• UniProt AC: Q9BX74
• Protein Name: TM2 domain-containing protein 1
• Gene Name: TM2D1
• Organism: Homo sapiens (Human).
• Sequence Length: 207
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42..
• Protein Sequence: MAAAWPSGPSAPEAVTARLVGVLWFVSVTTGPWGAVATSAGGEESLKCEDLKVGQYICKDPKINDATQEPVNCTNYTAHVSCFPAPNITCKDSSGNETHFTGNEVGFFKPISCRNVNGYSYKVAVALSLFLGWLGADRFYLGYPALGLLKFCTVGFCGIGSLIDFILISMQIVGPSDGSSYIIDYYGTRLTRLSITNETFRKTQLYP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	Ubiquitination	SLKCEDLKVGQYICK CCCCCCCCCCEEEEC	57.55	29967540
59	Ubiquitination	KVGQYICKDPKINDA CCCEEEECCCCCCCC	68.46	29967540
72	N-linked_Glycosylation	DATQEPVNCTNYTAH CCCCCCCCCCCCEEE	37.30	UniProtKB CARBOHYD
87	N-linked_Glycosylation	VSCFPAPNITCKDSS EEEEECCCCEEECCC	44.29	UniProtKB CARBOHYD
96	N-linked_Glycosylation	TCKDSSGNETHFTGN EEECCCCCEEEECCC	53.60	UniProtKB CARBOHYD
109	Ubiquitination	GNEVGFFKPISCRNV CCCCEEECEEEEECC	38.90	-
197	N-linked_Glycosylation	LTRLSITNETFRKTQ EEEEEEECCCHHHCC	44.64	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM2D1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM2D1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM2D1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TM2D1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.