TM1L1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM1L1_MOUSE
• UniProt AC: Q923U0
• Protein Name: TOM1-like protein 1
• Gene Name: Tom1l1
• Organism: Mus musculus (Mouse).
• Sequence Length: 474
• Subcellular Localization: Golgi apparatus, Golgi stack. Endosome membrane . Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. A small proportion is membrane-associated..
• Protein Description: Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions..
• Protein Sequence: MAFGKSHRDPYATSVGHLIEKATFAGVLTEDWGQFLHICDIINTTQDGPKDAVKALKKRISKNYNHKEIQLSLSLIDMCVQNCGPSFQSLIVKKEFIKDTLVKLLNPRYTLPLETQNRILNFIKTWSQGFPGGVDVSEVKEVYLDLLKKGVQFPPSDGEPETRQEAGQISPNRPTSVPTAPALSSIIAPKNPTISLVPEQIGKLHSELDMVKMNVKVMTAILMENTPGSENHEDIELLRKLYKTGREMQERIMDLLVVVENEDVTMELIQVNEDLNNAVLGYERFTRNQQRLLEQKRNRTEATRTSSEPSAPSCDLLDLSPIVPVPTPNEGALNSVNAQLSGLSVSSLSPVITNNLYPSLQPQRDLLASEDIEIPTLFPQRTSQNLASSHTYDNFHSNSVLLQPVSLHTATAAAAANQRLPPLPSSHPVLKDGDLQPPNYYEVMEFDPLAPTTEAVYEEIDGYHQKEAQSHSDC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MAFGKSHRDPYA ---CCCCCCCCCCCH	36.31	22790023
11	Phosphorylation	GKSHRDPYATSVGHL CCCCCCCCHHHHHHH	27.14	27180971
13	Phosphorylation	SHRDPYATSVGHLIE CCCCCCHHHHHHHHH	20.36	27180971
14	Phosphorylation	HRDPYATSVGHLIEK CCCCCHHHHHHHHHH	20.23	27180971
109	Phosphorylation	VKLLNPRYTLPLETQ HHHHCCCCCCCHHHH	17.56	29514104
125	Phosphorylation	RILNFIKTWSQGFPG HHHHHHHHHHCCCCC	26.07	30165576
127	Phosphorylation	LNFIKTWSQGFPGGV HHHHHHHHCCCCCCC	26.17	30165576
137	Phosphorylation	FPGGVDVSEVKEVYL CCCCCCHHHHHHHHH	32.01	30165576
148	Ubiquitination	EVYLDLLKKGVQFPP HHHHHHHHHCCCCCC	55.57	22790023
170	Phosphorylation	RQEAGQISPNRPTSV HHHCCCCCCCCCCCC	14.29	25521595
175	Phosphorylation	QISPNRPTSVPTAPA CCCCCCCCCCCCCCH	38.84	26643407
176	Phosphorylation	ISPNRPTSVPTAPAL CCCCCCCCCCCCCHH	28.87	25521595
179	Phosphorylation	NRPTSVPTAPALSSI CCCCCCCCCCHHHHC	43.02	29472430
184	Phosphorylation	VPTAPALSSIIAPKN CCCCCHHHHCCCCCC	22.92	29472430
185	Phosphorylation	PTAPALSSIIAPKNP CCCCHHHHCCCCCCC	20.90	29472430
190	Ubiquitination	LSSIIAPKNPTISLV HHHCCCCCCCCEECC	67.54	22790023
313	Phosphorylation	SSEPSAPSCDLLDLS CCCCCCCCCCCCCCC	21.71	-
320	Phosphorylation	SCDLLDLSPIVPVPT CCCCCCCCCCCCCCC	16.55	-
382	Phosphorylation	PTLFPQRTSQNLASS CCCCCCCCCCCCHHC	29.44	25367039
383	Phosphorylation	TLFPQRTSQNLASSH CCCCCCCCCCCHHCC	21.18	25367039
388	Phosphorylation	RTSQNLASSHTYDNF CCCCCCHHCCCCCCC	26.31	25367039
389	Phosphorylation	TSQNLASSHTYDNFH CCCCCHHCCCCCCCC	17.78	25367039
391	Phosphorylation	QNLASSHTYDNFHSN CCCHHCCCCCCCCCC	34.22	25367039
392	Phosphorylation	NLASSHTYDNFHSNS CCHHCCCCCCCCCCC	11.94	19798056
397	Phosphorylation	HTYDNFHSNSVLLQP CCCCCCCCCCEEEEE	27.02	25367039
399	Phosphorylation	YDNFHSNSVLLQPVS CCCCCCCCEEEEEEC	19.70	25367039
440	Phosphorylation	GDLQPPNYYEVMEFD CCCCCCCEEEEEECC	13.53	22817900
441	Phosphorylation	DLQPPNYYEVMEFDP CCCCCCEEEEEECCC	14.53	22817900
457	Phosphorylation	APTTEAVYEEIDGYH CCCHHHHHHHHCCCC	18.20	12601080

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
392	Y	Phosphorylation	Kinase	FYN	P39688	PSP
440	Y	Phosphorylation	Kinase	FYN	P39688	PSP
441	Y	Phosphorylation	Kinase	FYN	P39688	PSP
457	Y	Phosphorylation	Kinase	FYN	P39688	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM1L1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM1L1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLH1_MOUSE	Cltc	physical	17785434

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.