TM169_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM169_HUMAN
• UniProt AC: Q96HH4
• Protein Name: Transmembrane protein 169
• Gene Name: TMEM169
• Organism: Homo sapiens (Human).
• Sequence Length: 297
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MEEPTAVEGQVQLPSPHQGSLRKAVAAALALDGESTMGHRKKKRKESRPESIIIYRSDNEKTDEEPGESEGGDQPKEEEGDDFLDYPVDDDMWNLPLDSRYVTLTGTITRGKKKGQMVDIHVTLTEKELQELTKPKESSRETTPEGRMACQMGADRGPHVVLWTLICLPVVFILSFVVSFYYGTITWYNIFLVYNEERTFWHKISYCPCLVLFYPVLIMAMASSLGLYAAVVQLSWSWEAWWQAARDMEKGFCGWLCSKLGLEDCSPYSIVELLESDNISSTLSNKDPIQEVETSTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MEEPTAVEGQVQ ---CCCCCCEECEEC	46.76	26074081
15	Phosphorylation	EGQVQLPSPHQGSLR ECEECCCCCCCCHHH	43.54	29255136
20	Phosphorylation	LPSPHQGSLRKAVAA CCCCCCCHHHHHHHH	20.59	29255136
35	Phosphorylation	ALALDGESTMGHRKK HHHHCCCCCCCCHHH	29.26	29255136
36	Phosphorylation	LALDGESTMGHRKKK HHHCCCCCCCCHHHC	23.91	29255136
41	Ubiquitination	ESTMGHRKKKRKESR CCCCCCHHHCCCCCC	57.90	21906983
42	Ubiquitination	STMGHRKKKRKESRP CCCCCHHHCCCCCCC	58.74	21906983
47	Phosphorylation	RKKKRKESRPESIII HHHCCCCCCCCCEEE	57.05	28857561
51	Phosphorylation	RKESRPESIIIYRSD CCCCCCCCEEEEECC	23.05	27422710
57	Phosphorylation	ESIIIYRSDNEKTDE CCEEEEECCCCCCCC	28.02	28355574
101	Phosphorylation	NLPLDSRYVTLTGTI CCCCCCCEEEEEEEE	11.18	27642862
103	Phosphorylation	PLDSRYVTLTGTITR CCCCCEEEEEEEEEC	15.07	30576142
105	Phosphorylation	DSRYVTLTGTITRGK CCCEEEEEEEEECCC	23.94	25850435
107	Phosphorylation	RYVTLTGTITRGKKK CEEEEEEEEECCCCC	17.59	30576142
109	Phosphorylation	VTLTGTITRGKKKGQ EEEEEEEECCCCCCC	32.96	20562096
203	Sumoylation	EERTFWHKISYCPCL CCCCHHHHCCCCHHH	24.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM169_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM169_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM169_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TM169_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.