TM135_HUMAN - dbPTM
TM135_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TM135_HUMAN
UniProt AC Q86UB9
Protein Name Transmembrane protein 135
Gene Name TMEM135 {ECO:0000312|HGNC:HGNC:26167}
Organism Homo sapiens (Human).
Sequence Length 458
Subcellular Localization Mitochondrion membrane
Multi-pass membrane protein . Peroxisome membrane
Multi-pass membrane protein .
Protein Description Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization..
Protein Sequence MAALSKSIPHNCYEIGHTWHPSCRVSFLQITGGALEESLKIYAPLYLIAAILRKRKLDYYLHKLLPEILQSASFLTANGALYMAFFCILRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMANLATETLFRMGVARGTITTLRNGEVLLFCITAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGKFAVMNRKVLDVFGTGASKHFQDFIPRLDPRYTTVTPELPTEFS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
33UbiquitinationSFLQITGGALEESLK
EEEEEECCHHHHHHH		20.5222817900
37UbiquitinationITGGALEESLKIYAP
EECCHHHHHHHHHHH		63.3221963094
44UbiquitinationESLKIYAPLYLIAAI
HHHHHHHHHHHHHHH		12.4522817900
48UbiquitinationIYAPLYLIAAILRKR
HHHHHHHHHHHHHHH		1.2121963094
50UbiquitinationAPLYLIAAILRKRKL
HHHHHHHHHHHHHCH		8.3822817900
61UbiquitinationKRKLDYYLHKLLPEI
HHCHHHHHHHHHHHH		2.0322817900
88UbiquitinationLYMAFFCILRKILGK
HHHHHHHHHHHHHCH		3.3522817900
92UbiquitinationFFCILRKILGKFYSW
HHHHHHHHHCHHCCC		5.0521963094
97PhosphorylationRKILGKFYSWTPGFG
HHHHCHHCCCCCCCC		13.5422817900
98PhosphorylationKILGKFYSWTPGFGA
HHHCHHCCCCCCCCC		27.8328270605
100PhosphorylationLGKFYSWTPGFGAAL
HCHHCCCCCCCCCCC		13.9528270605
105UbiquitinationSWTPGFGAALPASYV
CCCCCCCCCCCHHHH		11.9922817900
110PhosphorylationFGAALPASYVAILIE
CCCCCCHHHHHHHHH		20.4228270605
111PhosphorylationGAALPASYVAILIER
CCCCCHHHHHHHHHC		8.9422817900
126 (in isoform 2)Phosphorylation-18.3324043423
128PhosphorylationRRGLLTIYMANLATE
CCCCHHHHHHHHHHH		5.73-
128 (in isoform 2)Phosphorylation-5.7324043423
139 (in isoform 2)Phosphorylation-24.8624043423
143 (in isoform 2)Phosphorylation-9.8424043423
146PhosphorylationRMGVARGTITTLRNG
HHHCCCCCEEECCCC		15.0330631047
148PhosphorylationGVARGTITTLRNGEV
HCCCCCEEECCCCCH		21.4430631047
150UbiquitinationARGTITTLRNGEVLL
CCCCEEECCCCCHHH		2.7622817900
154UbiquitinationITTLRNGEVLLFCIT
EEECCCCCHHHHHHH		33.2821963094
161PhosphorylationEVLLFCITAAMYMFF
CHHHHHHHHHHHHHH		15.0029900121
167UbiquitinationITAAMYMFFFRCKDG
HHHHHHHHHHHCCCC		2.6322817900
167 (in isoform 2)Ubiquitination-2.6321890473
172UbiquitinationYMFFFRCKDGLKGFT
HHHHHHCCCCCCCCC		51.0422817900
176UbiquitinationFRCKDGLKGFTFSAL
HHCCCCCCCCCEEEH		58.4721963094
181O-linked_GlycosylationGLKGFTFSALRFIVG
CCCCCCEEEHHHHHC		24.2830620550
189UbiquitinationALRFIVGKEEIPTHS
EHHHHHCCCCCCCCC		41.0821906983
189 (in isoform 1)Ubiquitination-41.0821890473
194PhosphorylationVGKEEIPTHSFSPEA
HCCCCCCCCCCCHHH		35.4923684312
196PhosphorylationKEEIPTHSFSPEAAY
CCCCCCCCCCHHHHH		29.8723684312
198PhosphorylationEIPTHSFSPEAAYAK
CCCCCCCCHHHHHHH		25.5025849741
203PhosphorylationSFSPEAAYAKVEQKR
CCCHHHHHHHHHHHH		17.6327642862
225UbiquitinationGRMNMIGLVRKFVDS
CCCHHHHHHHHHHHH		2.0322817900
228UbiquitinationNMIGLVRKFVDSICK
HHHHHHHHHHHHHHH		42.11-
236UbiquitinationFVDSICKHGPRHRCC
HHHHHHHCCCCCCCC		47.2622817900
280UbiquitinationRIPSAFRHLFTQPSR
HCCHHHHHHHCCHHH		20.8822817900
283UbiquitinationSAFRHLFTQPSRLLS
HHHHHHHCCHHHHHH		46.0222817900
294UbiquitinationRLLSLFYNKENFQLG
HHHHHHCCCCCCCHH		37.5221890473
305UbiquitinationFQLGAFLGSFVSIYK
CCHHHHHHHHHHHHC		16.7521890473
338UbiquitinationIIAGFLAGISMMFYK
HHHHHHHHHHHHHHH		18.0422817900
342 (in isoform 2)Ubiquitination-2.3721890473
342UbiquitinationFLAGISMMFYKSTTI
HHHHHHHHHHHHHHH		2.3722817900
344PhosphorylationAGISMMFYKSTTISM
HHHHHHHHHHHHHHH		6.02-
346PhosphorylationISMMFYKSTTISMYL
HHHHHHHHHHHHHHH		21.2828270605
347PhosphorylationSMMFYKSTTISMYLA
HHHHHHHHHHHHHHH		24.8128270605
348PhosphorylationMMFYKSTTISMYLAS
HHHHHHHHHHHHHHH		20.3928270605
349UbiquitinationMFYKSTTISMYLASK
HHHHHHHHHHHHHHH		1.9521890473
350PhosphorylationFYKSTTISMYLASKL
HHHHHHHHHHHHHHH		10.1628270605
352PhosphorylationKSTTISMYLASKLVE
HHHHHHHHHHHHHHH		7.7328270605
355PhosphorylationTISMYLASKLVETMY
HHHHHHHHHHHHHHH		24.7528270605
360PhosphorylationLASKLVETMYFKGIE
HHHHHHHHHHHCCCC		15.0828270605
362PhosphorylationSKLVETMYFKGIEAG
HHHHHHHHHCCCCCC		15.0128270605
364UbiquitinationLVETMYFKGIEAGKV
HHHHHHHCCCCCCCC		41.3021906983
364 (in isoform 1)Ubiquitination-41.3021890473
393UbiquitinationTAICFQAAVMEVQTL
HHHHHHHHHHHHHHH		7.1529967540
400 (in isoform 2)Ubiquitination-4.1921890473
400UbiquitinationAVMEVQTLRPSYWKF
HHHHHHHHCHHHHHH		4.1922817900
411UbiquitinationYWKFLLRLTKGKFAV
HHHHHHHHHCCCEEE		6.1421890473
411 (in isoform 2)Ubiquitination-6.1421890473
415UbiquitinationLLRLTKGKFAVMNRK
HHHHHCCCEEEECCH		31.5429967540
422 (in isoform 1)Ubiquitination-41.9921890473
422UbiquitinationKFAVMNRKVLDVFGT
CEEEECCHHHHHHCC		41.9922817900
433 (in isoform 1)Ubiquitination-48.1521890473
433UbiquitinationVFGTGASKHFQDFIP
HHCCCHHHHHHHHHH		48.1522817900
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TM135_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TM135_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TM135_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TM135_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TM135_HUMAN

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Related Literatures of Post-Translational Modification

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