TM127_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM127_HUMAN
• UniProt AC: O75204
• Protein Name: Transmembrane protein 127
• Gene Name: TMEM127
• Organism: Homo sapiens (Human).
• Sequence Length: 238
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cytoplasm . Association of TMEM127 with the cell membrane is enhanced by inhibition of endocytosis. In the cytoplasm, it colocalizes with markers of early endosomal structures, Golgi apparatus and lysosom
• Protein Description: Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor..
• Protein Sequence: MYAPGGAGLPGGRRRRSPGGSALPKQPERSLASALPGALSITALCTALAEPAWLHIHGGTCSRQELGVSDVLGYVHPDLLKDFCMNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKKYHGSQVYVTFAVSFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEENEPYPAEYEVINQFQPPPAYTP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MYAPGGAG -------CCCCCCCC	6.09	25732826
2	Phosphorylation	------MYAPGGAGL ------CCCCCCCCC	22.85	24173317
17	Phosphorylation	PGGRRRRSPGGSALP CCCCCCCCCCCCCCC	26.53	28348404
21	Phosphorylation	RRRSPGGSALPKQPE CCCCCCCCCCCCCCC	32.33	-
25	Ubiquitination	PGGSALPKQPERSLA CCCCCCCCCCCHHHH	78.36	2113904
224	Phosphorylation	NEPYPAEYEVINQFQ CCCCCCCHHHHHCCC	20.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM127_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM127_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM127_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TM127_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 171300: Pheochromocytoma (PCC)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, AND MASSSPECTROMETRY.
PubMed: 18691976