TM109_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM109_RAT
• UniProt AC: Q6AYQ4
• Protein Name: Transmembrane protein 109
• Gene Name: Tmem109
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 243
• Subcellular Localization: Nucleus outer membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Sarcoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro..
• Protein Sequence: MAGAHSNPSWSRHLFKAVLMVLGALLLVHSASAQTHREFASPGQQKRESSADILTEIGRSLKETLDTWLGPETMHVISETLLQVMWAISSAISVACFALSGIAAQLLSALGLDGEQLTQVLKLSPSQVQTLLLWGAAALVIYWLLSLLLGLVLALLGRILGGLKLVLFVAGFVGLVRSVPDPSTRALLLLALLTVFALLSRLTGSRSSGTHLEAKVRGLERQIEELRGRQRRAAKIPRSMEEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	QTHREFASPGQQKRE HHHHHHCCCCHHHHH	34.58	28432305
215	Acetylation	SGTHLEAKVRGLERQ CCCHHHHHHHHHHHH	24.08	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM109_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM109_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM109_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TM109_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.