TLRN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TLRN1_HUMAN
• UniProt AC: Q9H1K6
• Protein Name: Talin rod domain-containing protein 1 {ECO:0000305}
• Gene Name: TLNRD1 {ECO:0000312|HGNC:HGNC:13519}
• Organism: Homo sapiens (Human).
• Sequence Length: 362
• Protein Description: Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells..
• Protein Sequence: MASGSAGKPTGEAASPAPASAIGGASSQPRKRLVSVCDHCKGKMQLVADLLLLSSEARPVLFEGPASSGAGAESFEQCRDTIIARTKGLSILTHDVQSQLNMGRFGEAGDSLVELGDLVVSLTECSAHAAYLAAVATPGAQPAQPGLVDRYRVTRCRHEVEQGCAVLRATPLADMTPQLLLEVSQGLSRNLKFLTDACALASDKSRDRFSREQFKLGVKCMSTSASALLACVREVKVAPSELARSRCALFSGPLVQAVSALVGFATEPQFLGRAAAVSAEGKAVQTAILGGAMSVVSACVLLTQCLRDLAQHPDGGAKMSDHRERLRNSACAVSEGCTLLSQALRERSSPRTLPPVNSNSVN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASGSAGKP ------CCCCCCCCC		19413330
3	Phosphorylation	-----MASGSAGKPT -----CCCCCCCCCC		29255136
5	Phosphorylation	---MASGSAGKPTGE ---CCCCCCCCCCCC		29255136
10	Phosphorylation	SGSAGKPTGEAASPA CCCCCCCCCCCCCCC		25850435
15	Phosphorylation	KPTGEAASPAPASAI CCCCCCCCCCCHHHH		25850435
20	Phosphorylation	AASPAPASAIGGASS CCCCCCHHHHCCCCC		28857561
27	Phosphorylation	SAIGGASSQPRKRLV HHHCCCCCCCCHHHH		28857561
35	Phosphorylation	QPRKRLVSVCDHCKG CCCHHHHHHHHHCCC		22817900
41	2-Hydroxyisobutyrylation	VSVCDHCKGKMQLVA HHHHHHCCCHHHHHH		-
204	Ubiquitination	ACALASDKSRDRFSR HHHHHCCCCCCCCCH		-
236	Ubiquitination	LACVREVKVAPSELA HHHHHHCCCCHHHHH		-
329	Phosphorylation	HRERLRNSACAVSEG HHHHHHHHHHHHHHH		27732954
334	Phosphorylation	RNSACAVSEGCTLLS HHHHHHHHHHHHHHH		27732954
338	Phosphorylation	CAVSEGCTLLSQALR HHHHHHHHHHHHHHH		27732954
341	Phosphorylation	SEGCTLLSQALRERS HHHHHHHHHHHHHCC		27732954
348	Phosphorylation	SQALRERSSPRTLPP HHHHHHCCCCCCCCC		17081983
349	Phosphorylation	QALRERSSPRTLPPV HHHHHCCCCCCCCCC		17081983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TLRN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TLRN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TLRN1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TLRN1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.