TLE6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TLE6_HUMAN
• UniProt AC: Q9H808
• Protein Name: Transducin-like enhancer protein 6
• Gene Name: TLE6
• Organism: Homo sapiens (Human).
• Sequence Length: 572
• Subcellular Localization: Cytoplasm. In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity)..
• Protein Description: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions..
• Protein Sequence: MTSRDQPRPKGPPKSTSPCPGISNSESSPTLNYQGILNRLKQFPRFSPHFAAELESIYYSLHKIQQDVAEHHKQIGNVLQIVESCSQLQGFQSEEVSPAEPASPGTPQQVKDKTLQESSFEDIMATRSSDWLRRPLGEDNQPETQLFWDKEPWFWHDTLTEQLWRIFAGVHDEKAKPRDRQQAPGLGQESKAPGSCDPGTDPCPEDASTPRPPEASSSPPEGSQDRNTSWGVVQEPPGRASRFLQSISWDPEDFEDAWKRPDALPGQSKRLAVPCKLEKMRILAHGELVLATAISSFTRHVFTCGRRGIKVWSLTGQVAEDRFPESHLPIQTPGAFLRTCLLSSNSRSLLTGGYNLASVSVWDLAAPSLHVKEQLPCAGLNCQALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYNIWTGGPDACLRCWDQRTIMKPLEYQFKSQIMSLSHSPQEDWVLLGMANGQQWLQSTSGSQRHMVGQKDSVILSVKFSPFGQWWASVGMDDFLGVYSMPAGTKVFEVPEMSPVTCCDVSSNNRLVVTGSGEHASVYQITY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	AAELESIYYSLHKIQ HHHHHHHHHHHHHHH	48.34	-
59	Phosphorylation	AELESIYYSLHKIQQ HHHHHHHHHHHHHHH	50.87	27642862
60	Phosphorylation	ELESIYYSLHKIQQD HHHHHHHHHHHHHHH	7.56	-
190	Phosphorylation	APGLGQESKAPGSCD CCCCCCCCCCCCCCC	21.02	29485707
303	Phosphorylation	SFTRHVFTCGRRGIK HHHHHHHHCCCCCEE	20.43	-
506	Phosphorylation	QKDSVILSVKFSPFG CCCEEEEEEEECCCC		24719451
510	Phosphorylation	VILSVKFSPFGQWWA EEEEEEECCCCCHHH		14702039
568	Phosphorylation	SGEHASVYQITY--- CCCCEEEEEEEC---		27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
510	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TLE6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TLE6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TLE6_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.