TKT_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TKT_RAT
• UniProt AC: P50137
• Protein Name: Transketolase
• Gene Name: Tkt
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 623
• Protein Description: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate..
• Protein Sequence: MEGYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKALDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLPEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAYTGKYFDKASYRVYCMLGDGEVSEGSVWEAMAFAGIYKLDNLVAIFDINRLGQSDPAPLQHQVDVYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIAKTFKGRGITGIEDKEAWHGKPLPKNMAEQIIQEIYSQVQSKKKILATPPQEDAPSVDIANIRMPTPPNYKVGDKIATRKAYGLALAKLGHASDRIIALDGDTKNSTFSELFKKEHPDRFIECYIAEQNMVSIAVGCATRDRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPMSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYSNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAEMLKKEKIGVRVLDPFTIKPLDKKLILDCARATKGRILTVEDHYYEGGIGEAVSAVVVGEPGVTVTRLAVSQVPRSGKPAELLKMFGIDKDAIVQAVKGLVTKG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEGYHKPD -------CCCCCCCC	8.99	-
6	Acetylation	--MEGYHKPDQQKLQ --CCCCCCCCHHHHH	41.63	14878451
11	Acetylation	YHKPDQQKLQALKDT CCCCCHHHHHHHHHH	36.61	22902405
16	Acetylation	QQKLQALKDTANRLR HHHHHHHHHHHHHHH	56.92	22902405
59	Acetylation	FFHTMRYKALDPRNP HHHHHHCCCCCCCCC	31.91	22902405
104	Phosphorylation	LLNLRKISSDLDGHP HHCHHHCCCCCCCCC	22.34	23984901
105	Phosphorylation	LNLRKISSDLDGHPV HCHHHCCCCCCCCCC	45.74	28432305
144	Acetylation	YTGKYFDKASYRVYC HCCCCCCCCCEEEEE	29.36	22633187
150	Phosphorylation	DKASYRVYCMLGDGE CCCCEEEEEEECCCC	2.31	26022182
173	Phosphorylation	AMAFAGIYKLDNLVA HHHHHCEEECCCEEE	12.46	26022182
204	Acetylation	HQVDVYQKRCEAFGW HHHHHHHHHHHHHCC	41.13	22902405
232	Acetylation	CKAFGQAKHQPTAII HHHHCCCCCCCCEEE	34.58	22902405
241	Acetylation	QPTAIIAKTFKGRGI CCCEEEEEECCCCCC	44.05	22902405
254	Ubiquitination	GITGIEDKEAWHGKP CCCCCCCHHHHCCCC	36.22	-
254	Acetylation	GITGIEDKEAWHGKP CCCCCCCHHHHCCCC	36.22	22902405
260	Succinylation	DKEAWHGKPLPKNMA CHHHHCCCCCCHHHH	30.41	26843850
260	Acetylation	DKEAWHGKPLPKNMA CHHHHCCCCCCHHHH	30.41	22902405
275	Phosphorylation	EQIIQEIYSQVQSKK HHHHHHHHHHHHCCC	7.72	27097102
276	Phosphorylation	QIIQEIYSQVQSKKK HHHHHHHHHHHCCCC	29.54	27097102
280	Phosphorylation	EIYSQVQSKKKILAT HHHHHHHCCCCCCCC	47.81	28689409
281	Acetylation	IYSQVQSKKKILATP HHHHHHCCCCCCCCC	40.78	22902405
282	Ubiquitination	YSQVQSKKKILATPP HHHHHCCCCCCCCCC	50.74	-
283	Ubiquitination	SQVQSKKKILATPPQ HHHHCCCCCCCCCCC	46.84	-
287	Phosphorylation	SKKKILATPPQEDAP CCCCCCCCCCCCCCC	31.86	29779826
295	Phosphorylation	PPQEDAPSVDIANIR CCCCCCCCCCCCCCC	33.86	27097102
305	Phosphorylation	IANIRMPTPPNYKVG CCCCCCCCCCCCCCC	41.87	21738781
309	Phosphorylation	RMPTPPNYKVGDKIA CCCCCCCCCCCCCHH	16.90	23984901
310	Acetylation	MPTPPNYKVGDKIAT CCCCCCCCCCCCHHH	46.51	22902405
314	Acetylation	PNYKVGDKIATRKAY CCCCCCCCHHHHHHH	28.45	22902405
319	Acetylation	GDKIATRKAYGLALA CCCHHHHHHHHHHHH	41.42	22902405
327	Acetylation	AYGLALAKLGHASDR HHHHHHHHHCCCCCC	56.71	22902405
342	Phosphorylation	IIALDGDTKNSTFSE EEEECCCCCCCCHHH	37.34	22673903
345	Phosphorylation	LDGDTKNSTFSELFK ECCCCCCCCHHHHHH	32.17	21738781
346	Phosphorylation	DGDTKNSTFSELFKK CCCCCCCCHHHHHHH	40.34	23984901
348	Phosphorylation	DTKNSTFSELFKKEH CCCCCCHHHHHHHHC	33.22	23984901
352	Acetylation	STFSELFKKEHPDRF CCHHHHHHHHCCCCE	70.63	22902405
353	Acetylation	TFSELFKKEHPDRFI CHHHHHHHHCCCCEE	54.65	22902405
481	Phosphorylation	RPENAIIYSNNEDFQ CCCCEEEECCCCCCC	10.15	25575281
482	Phosphorylation	PENAIIYSNNEDFQV CCCEEEECCCCCCCC	23.83	28689409
499	Acetylation	AKVVLKSKDDQVTVI EEEEEECCCCCEEEE	64.83	22902405
523	Acetylation	LAAAEMLKKEKIGVR HHHHHHHHHCCCCCE	58.54	22902405
538	Acetylation	VLDPFTIKPLDKKLI EECCCCCCCCCCHHH	36.15	22902405
538	Succinylation	VLDPFTIKPLDKKLI EECCCCCCCCCCHHH	36.15	26843850
542	Acetylation	FTIKPLDKKLILDCA CCCCCCCCHHHHHHH	58.10	22902405
590	Phosphorylation	TVTRLAVSQVPRSGK EEEEEEEECCCCCCC	21.61	28689409
597	Acetylation	SQVPRSGKPAELLKM ECCCCCCCHHHHHHH	42.15	22902405
603	Acetylation	GKPAELLKMFGIDKD CCHHHHHHHHCCCHH	44.82	22902405
609	Acetylation	LKMFGIDKDAIVQAV HHHHCCCHHHHHHHH	47.33	22902405
609	Succinylation	LKMFGIDKDAIVQAV HHHHCCCHHHHHHHH	47.33	26843850

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TKT_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TKT_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TKT_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TKT_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.