TKTC1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TKTC1_ARATH
• UniProt AC: Q8RWV0
• Protein Name: Transketolase-1, chloroplastic
• Gene Name: TKL-1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 741
• Subcellular Localization: Plastid, chloroplast stroma .
• Protein Description: Catalyzes the reversible transfer of a two-carbon ketol group from fructose-6-phosphate or sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate to yield xylulose-5-phosphate and erythrose-4-phosphate or ribose-5-phosphate, respectively (By similarity). Could act as a stress sensor involved in adaptation process..
• Protein Sequence: MASTSSLALSQALLARAISHHGSDQRGSLPAFSGLKSTGSRASASSRRRIAQSMTKNRSLRPLVRAAAVETVEPTTDSSIVDKSVNSIRFLAIDAVEKAKSGHPGLPMGCAPMAHILYDEVMRYNPKNPYWFNRDRFVLSAGHGCMLLYALLHLAGYDSVQEEDLKQFRQWGSKTPGHPENFETPGIEVTTGPLGQGIANAVGLALAEKHLAARFNKPDAEVVDHYTYAILGDGCQMEGISNEACSLAGHWGLGKLIAFYDDNHISIDGDTEIAFTENVDQRFEALGWHVIWVKNGNTGYDEIRAAIKEAKTVTDKPTLIKVTTTIGYGSPNKANSYSVHGAALGEKEVEATRNNLGWPYEPFQVPDDVKSHWSRHTPEGATLESDWSAKFAAYEKKYPEEASELKSIITGELPAGWEKALPTYTPESPGDATRNLSQQCLNALAKVVPGFLGGSADLASSNMTLLKAFGDFQKATPEERNLRFGVREHGMGAICNGIALHSPGLIPYCATFFVFTDYMRGAMRISALSEAGVIYVMTHDSIGLGEDGPTHQPIEHIASFRAMPNTLMFRPADGNETAGAYKIAVTKRKTPSILALSRQKLPHLPGTSIEGVEKGGYTISDDSSGNKPDVILIGTGSELEIAAQAAEVLRKDGKTVRVVSFVCWELFDEQSDEYKESVLPSDVSARVSIEAASTFGWGKIVGGKGKSIGINSFGASAPAPLLYKEFGITVEAVVDAAKSFF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	PAFSGLKSTGSRASA CCCCCCCCCCCCCCH		23776212
38	Phosphorylation	AFSGLKSTGSRASAS CCCCCCCCCCCCCHH		23776212
40	Phosphorylation	SGLKSTGSRASASSR CCCCCCCCCCCHHHH		23776212
43	Phosphorylation	KSTGSRASASSRRRI CCCCCCCCHHHHHHH		23776212
45	Phosphorylation	TGSRASASSRRRIAQ CCCCCCHHHHHHHHH		23776212
46	Phosphorylation	GSRASASSRRRIAQS CCCCCHHHHHHHHHH		23776212
67	Acetylation	LRPLVRAAAVETVEP HHHHHHHHHEEECCC		22223895
71	Phosphorylation	VRAAAVETVEPTTDS HHHHHEEECCCCCCC		30291188
173	Phosphorylation	KQFRQWGSKTPGHPE HHHHHHCCCCCCCCC		29797451
336	Phosphorylation	GSPNKANSYSVHGAA CCCCCCCCEEECCCC		22092075
338	Phosphorylation	PNKANSYSVHGAALG CCCCCCEEECCCCCC		25561503
371	Phosphorylation	QVPDDVKSHWSRHTP CCCCCHHHHHHHCCC		29654922
377	Phosphorylation	KSHWSRHTPEGATLE HHHHHHCCCCCCCCC		21768351
385	Phosphorylation	PEGATLESDWSAKFA CCCCCCCCHHHHHHH		30291188
403	Phosphorylation	KKYPEEASELKSIIT HHCHHHHHHHHHHHH		30291188
423	Phosphorylation	GWEKALPTYTPESPG CHHHCCCCCCCCCCC		23776212
424	Phosphorylation	WEKALPTYTPESPGD HHHCCCCCCCCCCCH		23776212
425	Phosphorylation	EKALPTYTPESPGDA HHCCCCCCCCCCCHH		23776212
428	Phosphorylation	LPTYTPESPGDATRN CCCCCCCCCCHHHHH		30291188
433	Phosphorylation	PESPGDATRNLSQQC CCCCCHHHHHHHHHH		23776212
437	Phosphorylation	GDATRNLSQQCLNAL CHHHHHHHHHHHHHH		30291188
590	Phosphorylation	IAVTKRKTPSILALS EEEECCCCHHHHEEC		25561503
592	Phosphorylation	VTKRKTPSILALSRQ EECCCCHHHHEECCC		25561503
597	Phosphorylation	TPSILALSRQKLPHL CHHHHEECCCCCCCC		25561503
712	Phosphorylation	GKSIGINSFGASAPA CCEEEECCCCCCCCC		19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TKTC1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TKTC1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TKTC1_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of TKTC1_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.