TIP21_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIP21_ARATH
• UniProt AC: Q41951
• Protein Name: Aquaporin TIP2-1
• Gene Name: TIP2-1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 250
• Subcellular Localization: Vacuole membrane ; Multi-pass membrane protein . Tonoplast. It is specifically located in the tonoplast of protein storage vacuoles (PSV) (By similarity)..
• Protein Description: Aquaporin required to facilitate the transport of water from the vacuolar compartment to the cytoplasm. Does not promote glycerol permability. Its function is impaired by Hg(2+). Transports urea in yeast cells and Xenopus laevis oocytes in a pH-independent manner. Transports methylammonium or ammonium in yeast cells and Xenopus laevis oocytes, preferentially at high medium pH. May participate in vacuolar compartmentation and detoxification of ammonium..
• Protein Sequence: MAGVAFGSFDDSFSLASLRAYLAEFISTLLFVFAGVGSAIAYAKLTSDAALDTPGLVAIAVCHGFALFVAVAIGANISGGHVNPAVTFGLAVGGQITVITGVFYWIAQLLGSTAACFLLKYVTGGLAVPTHSVAAGLGSIEGVVMEIIITFALVYTVYATAADPKKGSLGTIAPLAIGLIVGANILAAGPFSGGSMNPARSFGPAVAAGDFSGHWVYWVGPLIGGGLAGLIYGNVFMGSSEHVPLASADF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MAGVAFGS -------CCCCCCCC	7.08	-
2	Acetylation	------MAGVAFGSF ------CCCCCCCCC	22.59	22223895
8	Phosphorylation	MAGVAFGSFDDSFSL CCCCCCCCCCCCCCH	21.03	27545962
12	Phosphorylation	AFGSFDDSFSLASLR CCCCCCCCCCHHHHH	20.69	27545962
14	Phosphorylation	GSFDDSFSLASLRAY CCCCCCCCHHHHHHH	27.29	27545962
17	Phosphorylation	DDSFSLASLRAYLAE CCCCCHHHHHHHHHH	24.55	27545962

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIP21_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIP21_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIP21_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NAC89_ARATH	NAC089	physical	21798944
NIP11_ARATH	NLM1	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.