dbPTM

TIM8A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TIM8A_MOUSE
UniProt AC	Q9WVA2
Protein Name	Mitochondrial import inner membrane translocase subunit Tim8 A
Gene Name	Timm8a1
Organism	Mus musculus (Mouse).
Sequence Length	97
Subcellular Localization	Mitochondrion inner membrane Peripheral membrane protein Intermembrane side.
Protein Description	Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins (By similarity)..
Protein Sequence	MESSTSSSGSALGAVDPQLQHFIEVETQKQRFQQLVHQMTELCWEKCMDKPGPKLDSRAEACFVNCVERFIDTSQFILNRLEQTQKSKPVFSESLSD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MESSTSSSGSA ----CCCCCCCCCCC	20.99	30352176
5	Phosphorylation	---MESSTSSSGSAL ---CCCCCCCCCCCC	41.74	25338131
8	Phosphorylation	MESSTSSSGSALGAV CCCCCCCCCCCCCCC	36.21	25338131
50	Acetylation	CWEKCMDKPGPKLDS HHHHHCCCCCCCCCH	25.62	23864654
54	Succinylation	CMDKPGPKLDSRAEA HCCCCCCCCCHHHHH	71.49	23954790
54	Malonylation	CMDKPGPKLDSRAEA HCCCCCCCCCHHHHH	71.49	26073543
54	Acetylation	CMDKPGPKLDSRAEA HCCCCCCCCCHHHHH	71.49	23864654
57	Phosphorylation	KPGPKLDSRAEACFV CCCCCCCHHHHHHHH	43.77	22817900
86	Acetylation	NRLEQTQKSKPVFSE HHHHHHHHCCCCCCC	64.93	23806337
86	Succinylation	NRLEQTQKSKPVFSE HHHHHHHHCCCCCCC	64.93	23806337
86	Ubiquitination	NRLEQTQKSKPVFSE HHHHHHHHCCCCCCC	64.93	-
86	Malonylation	NRLEQTQKSKPVFSE HHHHHHHHCCCCCCC	64.93	26320211
87	Phosphorylation	RLEQTQKSKPVFSES HHHHHHHCCCCCCCC	32.16	25619855
88	Ubiquitination	LEQTQKSKPVFSESL HHHHHHCCCCCCCCC	52.84	-
92	Phosphorylation	QKSKPVFSESLSD-- HHCCCCCCCCCCC--	26.89	27742792
94	Phosphorylation	SKPVFSESLSD---- CCCCCCCCCCC----	31.79	27742792
96	Phosphorylation	PVFSESLSD------ CCCCCCCCC------	51.02	27742792

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TIM8A_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TIM8A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TIM8A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TIM8A_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TIM8A_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, AND MASSSPECTROMETRY.	17242355 [Abstract]