TIM44_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIM44_RAT
• UniProt AC: O35094
• Protein Name: Mitochondrial import inner membrane translocase subunit TIM44
• Gene Name: Timm44
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 453
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side . Mitochondrion matrix .
• Protein Description: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source..
• Protein Sequence: MAAAALRGGWCRCPRRCLGSGIQFLSSHNLPRGGSSYQISRPGGELTLTKSYSSGSRKGFLSGLLDNIKQELAQNKEMKESIKKFRDEAKKLEESDALQEARRKYKTIESETVRTSEAIKKKLGELTGTVKESLDEVSKSDLGRKIKEGVEEAARTAKQSAESVSKGGEKLGKTAAFKAISQGVESVKKEIDESVLGHTGTYRRPERLRKRTEFAGAKFKESKVFEANEEALGVVLHKDSKWYQQWKDFKDNNVVFNRFFEMKMKYDESDNVLIRASRALTDKVTDLLGGLFSKTEMSEVLTEILRVDPTFDKDRFLHQCETDIIPNILEAMISGELDILKDWCYEATYNQLAHSIQQAKALGLQFHSRILDISNVDLAMGKMMEQGPVLIVTFQAQLVMVIKNPKGEVFDGDPDKVLRMLYVWALCRDQEELNPYAAWRLLDISASSTEQIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	CPRRCLGSGIQFLSS CCHHHCCCCCCHHHH	21.55	25575281
26	Phosphorylation	GSGIQFLSSHNLPRG CCCCCHHHHCCCCCC	30.73	25575281
27	Phosphorylation	SGIQFLSSHNLPRGG CCCCHHHHCCCCCCC	20.67	25575281
51	Phosphorylation	GELTLTKSYSSGSRK CEEEEEEEECCCCCC	25.63	16641100
52	Phosphorylation	ELTLTKSYSSGSRKG EEEEEEEECCCCCCH	14.38	16641100
53	Phosphorylation	LTLTKSYSSGSRKGF EEEEEEECCCCCCHH	35.00	16641100
54	Phosphorylation	TLTKSYSSGSRKGFL EEEEEECCCCCCHHH	32.33	16641100
56	Phosphorylation	TKSYSSGSRKGFLSG EEEECCCCCCHHHHH	32.54	16641100
91	Succinylation	KFRDEAKKLEESDAL HHHHHHHHHHHHHHH	69.08	26843850
129	Phosphorylation	KLGELTGTVKESLDE HHHHHHCCHHHHHHH	24.14	-
178	Acetylation	LGKTAAFKAISQGVE HCHHHHHHHHHHHHH	39.83	22902405
178	Succinylation	LGKTAAFKAISQGVE HCHHHHHHHHHHHHH	39.83	-
178	Succinylation	LGKTAAFKAISQGVE HCHHHHHHHHHHHHH	39.83	-
181	Phosphorylation	TAAFKAISQGVESVK HHHHHHHHHHHHHHH	26.24	-
218	Succinylation	RTEFAGAKFKESKVF HHHHCCCCCCCCCEE	56.93	-
218	Succinylation	RTEFAGAKFKESKVF HHHHCCCCCCCCCEE	56.93	-
313	Acetylation	RVDPTFDKDRFLHQC CCCCCCCHHHHHHHC	46.76	22902405
416	Acetylation	VFDGDPDKVLRMLYV CCCCCHHHHHHHHHH	48.86	22902405
445	Phosphorylation	AWRLLDISASSTEQI HHHHHHCCCCCCHHH	23.05	28432305
447	Phosphorylation	RLLDISASSTEQIL- HHHHCCCCCCHHHC-	30.88	28432305
448	Phosphorylation	LLDISASSTEQIL-- HHHCCCCCCHHHC--	35.36	28432305
449	Phosphorylation	LDISASSTEQIL--- HHCCCCCCHHHC---	29.43	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIM44_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIM44_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIM44_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TIM44_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.