TIM13_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIM13_MOUSE
• UniProt AC: P62075
• Protein Name: Mitochondrial import inner membrane translocase subunit Tim13
• Gene Name: Timm13
• Organism: Mus musculus (Mouse).
• Sequence Length: 95
• Subcellular Localization: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
• Protein Description: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins (By similarity)..
• Protein Sequence: MDSGFGSDFGGTGGGKLDPGAIMEQVKVQIAVANAQELLQRMTDKCFRKCIGKPGGSLDNSEQKCIAMCMDRYMDAWNTVSRAYNSRLQRERANM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDSGFGSD -------CCCCCCCC	9.26	-
3	Phosphorylation	-----MDSGFGSDFG -----CCCCCCCCCC	34.42	26643407
7	Phosphorylation	-MDSGFGSDFGGTGG -CCCCCCCCCCCCCC	27.75	26643407
12	Phosphorylation	FGSDFGGTGGGKLDP CCCCCCCCCCCCCCH	32.79	26643407
49	Malonylation	MTDKCFRKCIGKPGG HHHHHHHHHHCCCCC	15.22	26320211
53	Succinylation	CFRKCIGKPGGSLDN HHHHHHCCCCCCCCC	22.15	-
53	Acetylation	CFRKCIGKPGGSLDN HHHHHHCCCCCCCCC	22.15	23806337
53	Succinylation	CFRKCIGKPGGSLDN HHHHHHCCCCCCCCC	22.15	23806337
57	Phosphorylation	CIGKPGGSLDNSEQK HHCCCCCCCCCHHHH	38.16	-
61	Phosphorylation	PGGSLDNSEQKCIAM CCCCCCCHHHHHHHH	40.86	23140645
64	Acetylation	SLDNSEQKCIAMCMD CCCCHHHHHHHHHHH	24.45	23864654
64	Malonylation	SLDNSEQKCIAMCMD CCCCHHHHHHHHHHH	24.45	26073543

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIM13_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIM13_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIM13_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TIM13_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.