dbPTM

THRC_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	THRC_SCHPO
UniProt AC	Q42598
Protein Name	Threonine synthase
Gene Name	thrc
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	514
Subcellular Localization
Protein Description	Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine..
Protein Sequence	MSSQVSYLSTRGGSSNFSFEEAVLKGLANDGGLFIPSEIPQLPSGWIEAWKDKSFPEIAFEVMSLYIPRSEISADELKKLVDRSYSTFRHPETTPLKSLKNGLNVLELFHGPTFAFKDVALQFLGNLFEFFLTRKNGNKPEDERDHLTVVGATSGDTGSAAIYGLRGKKDVSVFILFPNGRVSPIQEAQMTTVTDPNVHCITVNGVFDDCQDLVKQIFGDVEFNKKHHIGAVNSINWARILSQITYYLYSYLSVYKQGKADDVRFIVPTGNFGDILAGYYAKRMGLPTKQLVIATNENDILNRFFKTGRYEKADSTQVSPSGPISAKETYSPAMDILVSSNFERYLWYLALATEAPNHTPAEASEILSRWMNEFKRDGTVTVRPEVLEAARRDFVSERVSNDETIDAIKKIYESDHYIIDPHTAVGVETGLRCLEKTKDQDITYICLSTAHPAKFDKAVNLALSSYSDYNFNTQVLPIEFDGLLDEERTCIFSGKPNIDILKQIIEVTLSREKA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	YLSTRGGSSNFSFEE CCCCCCCCCCCCHHH	25.57	25720772
15	Phosphorylation	LSTRGGSSNFSFEEA CCCCCCCCCCCHHHH	45.21	25720772
117	N6-(pyridoxal phosphate)lysine	HGPTFAFKDVALQFL CCCCHHHHHHHHHHH	48.11	-
117	Other	HGPTFAFKDVALQFL CCCCHHHHHHHHHHH	48.11	-
315	Phosphorylation	GRYEKADSTQVSPSG CCCEECCCCCCCCCC	26.12	21712547
316	Phosphorylation	RYEKADSTQVSPSGP CCEECCCCCCCCCCC	33.27	29996109
319	Phosphorylation	KADSTQVSPSGPISA ECCCCCCCCCCCCCC	11.97	28889911
321	Phosphorylation	DSTQVSPSGPISAKE CCCCCCCCCCCCCCC	50.09	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of THRC_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of THRC_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of THRC_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of THRC_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of THRC_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319 AND SER-321, ANDMASS SPECTROMETRY.	18257517 [Abstract]