| UniProt ID | THOC1_ARATH | |
|---|---|---|
| UniProt AC | Q93VM9 | |
| Protein Name | THO complex subunit 1 | |
| Gene Name | THO1 | |
| Organism | Arabidopsis thaliana (Mouse-ear cress). | |
| Sequence Length | 599 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export. Contributes to the integrity of the endogenous trans-acting small interfering RNA (ta-siRNA) pathway. May process or transport a long RNA molecule so that it can be a template for secondary siRNA production. May participate in the trafficking of siRNA precursors to the ARGONAUTE catalytic center. Required for the generation of functional messenger ribonucleoproteins (mRNPs). Plays an important roles in plant innate immunity.. | |
| Protein Sequence | MDAFRDAILQRAPIETFALKTVQHFIQPQKQTKLAQDENQMLENMLRTLLQELVAAAAQSGEQIMQYGQLIDDDDDDDDIHGQIPHLLDVVLYLCEKEHVEGGMIFQLLEDLTEMSTMKNCKDVFGYIESKQDILGKQELFARGKLVMLRTCNQLLRRLSKANDVVFCGRILMFLAHFFPLSERSAVNIKGVFNTSNETKYEKDPPKGISVDFNFYKTFWSLQEYFCNPASLTSASTKWQKFSSSLAVVLNTFDAQPLSEEEGEANSLEEEAATFNIKYLTSSKLMGLELKDSSFRRHILLQCLIMFDYLRAPGKNDKDLPSETMKEELKSCEDRVKKLLEITPPKGKEFLRAVEHILEREKNWVWWKRDGCPPFEKQPIDKKSPNAGQKKRRQRWRLGNKELSQLWRWADQNPNALTDSQRVRTPDIADYWKPLAEDMDPSAGIEDEYHHKNNRVYCWKGLRFTARQDLEGFSRFTEMGIEGVVPVELLPPEVRSKYQAKPNEKAKRAKKEETKGGSHETEGNQIGVSNSEAEAEGGRGDAETMESDAIADTPTPEEQQRLGGSDTENGQEAGQIEDGETEEAGLMDTDLDHPPMPVS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 221 | Phosphorylation | NFYKTFWSLQEYFCN CHHHHHHHHHHHCCC | 24894044 | ||
| 231 | Phosphorylation | EYFCNPASLTSASTK HHCCCHHHCCCCCHH | 24894044 | ||
| 233 | Phosphorylation | FCNPASLTSASTKWQ CCCHHHCCCCCHHHH | 24894044 | ||
| 234 | Phosphorylation | CNPASLTSASTKWQK CCHHHCCCCCHHHHH | 24894044 | ||
| 236 | Phosphorylation | PASLTSASTKWQKFS HHHCCCCCHHHHHHH | 24894044 | ||
| 237 | Phosphorylation | ASLTSASTKWQKFSS HHCCCCCHHHHHHHH | 24894044 | ||
| 282 | Phosphorylation | FNIKYLTSSKLMGLE HCCEEHHHHCCCCCC | 19880383 | ||
| 283 | Phosphorylation | NIKYLTSSKLMGLEL CCEEHHHHCCCCCCC | 19880383 | ||
| 384 | Phosphorylation | KQPIDKKSPNAGQKK CCCCCCCCCCCCHHH | 25561503 | ||
| 544 | Phosphorylation | GGRGDAETMESDAIA CCCCCHHHHHCCCCC | 25561503 | ||
| 547 | Phosphorylation | GDAETMESDAIADTP CCHHHHHCCCCCCCC | 25561503 | ||
| 553 | Phosphorylation | ESDAIADTPTPEEQQ HCCCCCCCCCHHHHH | 30407730 | ||
| 555 | Phosphorylation | DAIADTPTPEEQQRL CCCCCCCCHHHHHHH | 30407730 | ||
| 565 | Phosphorylation | EQQRLGGSDTENGQE HHHHHCCCCCCCCCC | 23776212 | ||
| 567 | Phosphorylation | QRLGGSDTENGQEAG HHHCCCCCCCCCCCC | 23776212 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of THOC1_ARATH !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of THOC1_ARATH !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of THOC1_ARATH !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of THOC1_ARATH !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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