THIO_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THIO_RAT
• UniProt AC: P11232
• Protein Name: Thioredoxin
• Gene Name: Txn
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 105
• Subcellular Localization: Nucleus . Cytoplasm . Secreted . Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA). Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm
• Protein Description: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity)..
• Protein Sequence: MVKLIESKEAFQEALAAAGDKLVVVDFSATWCGPCKMIKPFFHSLCDKYSNVVFLEVDVDDCQDVAADCEVKCMPTFQFYKKGQKVGEFSGANKEKLEATITEFA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MVKLIESKEA -----CCEECCCHHH	42.31	65471293
8	Acetylation	MVKLIESKEAFQEAL CCEECCCHHHHHHHH	40.03	22902405
8	Succinylation	MVKLIESKEAFQEAL CCEECCCHHHHHHHH	40.03	-
8	Succinylation	MVKLIESKEAFQEAL CCEECCCHHHHHHHH	40.03	-
39	Acetylation	CGPCKMIKPFFHSLC CCCHHHHHHHHHHHH	32.07	22902405
44	Phosphorylation	MIKPFFHSLCDKYSN HHHHHHHHHHHHCCC	26.07	28432305
62	S-nitrosocysteine	LEVDVDDCQDVAADC EEEECCCHHHHHHCC	3.01	-
62	S-nitrosylation	LEVDVDDCQDVAADC EEEECCCHHHHHHCC	3.01	-
69	S-nitrosylation	CQDVAADCEVKCMPT HHHHHHCCEEEEECC	5.77	-
69	S-nitrosocysteine	CQDVAADCEVKCMPT HHHHHHCCEEEEECC	5.77	-
73	S-nitrosylation	AADCEVKCMPTFQFY HHCCEEEEECCEEEE	4.82	-
73	S-nitrosocysteine	AADCEVKCMPTFQFY HHCCEEEEECCEEEE	4.82	-
90	Phosphorylation	GQKVGEFSGANKEKL CCEEECCCCCCHHHH	32.47	30181290
94	Succinylation	GEFSGANKEKLEATI ECCCCCCHHHHEEEE	56.54	-
94	Acetylation	GEFSGANKEKLEATI ECCCCCCHHHHEEEE	56.54	22902405
94	Succinylation	GEFSGANKEKLEATI ECCCCCCHHHHEEEE	56.54	-
96	Succinylation	FSGANKEKLEATITE CCCCCHHHHEEEEEE	53.92	26843850
96	Ubiquitination	FSGANKEKLEATITE CCCCCHHHHEEEEEE	53.92	-
96	Acetylation	FSGANKEKLEATITE CCCCCHHHHEEEEEE	53.92	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of THIO_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THIO_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THIO_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of THIO_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.